| UniProt ID | PCD1_YEAST | |
|---|---|---|
| UniProt AC | Q12524 | |
| Protein Name | Peroxisomal coenzyme A diphosphatase 1, peroxisomal | |
| Gene Name | PCD1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 340 | |
| Subcellular Localization | Peroxisome . | |
| Protein Description | Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine. Has a strong preference for oxidized CoA disulfide (CoASSCoA) as substrate. May be required to remove potentially toxic oxidized CoA disulfide to maintain the capacity for beta-oxidation of fatty acids. Can degrade 8-oxo-dGTP in vitro; however, such activity may not be relevant in vivo.. | |
| Protein Sequence | MILSQRRMLSSKQLIENLIRYKFHKTPYTRSSIWPFKRNSAVIILLFIGMKGELRVLLTKRSRTLRSFSGDVSFPGGKADYFQETFESVARREAEEEIGLPHDPEVLHKEFGMKLDNLVMDMPCYLSRTFLSVKPMVCFLYKDKLEKHEDKYKVPLDIRKFFGKLNPGETSSLFSVPLNDLVIHLLPEADEDVKSYQAEYFERKEYKLNWGGIKWLIMHYHFHVANNNEMPWLQTIEDLSSSDEDGVDGGIFRFRDLWGLTCKILFDVSCIANGLMDEKLKGELGHEDLIVGLHDYGNQMQPNGRSEWEIGMINGDRNLKYSDVIPEYYMKHLLECRSLW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 69 | Phosphorylation | SRTLRSFSGDVSFPG CCCCHHCCCCCCCCC | 35.02 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCD1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCD1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCD1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TOS4_YEAST | TOS4 | genetic | 19269370 | |
| CG24_YEAST | CLB4 | genetic | 19269370 | |
| SLX5_YEAST | SLX5 | genetic | 27708008 | |
| YD391_YEAST | YDR391C | genetic | 27708008 | |
| ICE2_YEAST | ICE2 | genetic | 27708008 | |
| SWE1_YEAST | SWE1 | genetic | 27708008 | |
| AXL1_YEAST | AXL1 | genetic | 27708008 | |
| RS8A_YEAST | RPS8A | genetic | 27708008 | |
| RS8B_YEAST | RPS8A | genetic | 27708008 | |
| ELO2_YEAST | ELO2 | genetic | 27708008 | |
| THRC_YEAST | THR4 | genetic | 27708008 | |
| BMH2_YEAST | BMH2 | genetic | 27708008 | |
| GGA1_YEAST | GGA1 | genetic | 27708008 | |
| PHO86_YEAST | PHO86 | genetic | 27708008 | |
| CYP7_YEAST | CPR7 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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