MCFS2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCFS2_YEAST
• UniProt AC: P38295
• Protein Name: Medium-chain fatty acid ethyl ester synthase/esterase 2
• Gene Name: EHT1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 451
• Protein Description: Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification..
• Protein Sequence: MSEVSKWPAINPFHWGYNGTVSHIVGENGSIKLHLKDNKEQVDFDEFANKYVPTLKNGAQFKLSPYLFTGILQTLYLGAADFSKKFPVFYGREIVKFSDGGVCTADWLIDSWKKDYEFDQSTTSFDKKKFDKDEKATHPEGWPRLQPRTRYLKDNELEELREVDLPLVVILHGLAGGSHEPIIRSLAENLSRSGRFQVVVLNTRGCARSKITTRNLFTAYHTMDIREFLQREKQRHPDRKLYAVGCSFGATMLANYLGEEGDKSPLSAAATLCNPWDLLLSAIRMSQDWWSRTLFSKNIAQFLTRTVQVNMGELGVPNGSLPDHPPTVKNPSFYMFTPENLIKAKSFKSTREFDEVYTAPALGFPNAMEYYKAASSINRVDTIRVPTLVINSRDDPVVGPDQPYSIVEKNPRILYCRTDLGGHLAYLDKDNNSWATKAIAEFFTKFDELVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Acetylation	GSIKLHLKDNKEQVD CEEEEEECCCHHHCC	48.81	24489116
36	Ubiquitination	GSIKLHLKDNKEQVD CEEEEEECCCHHHCC	48.81	22817900
39	Acetylation	KLHLKDNKEQVDFDE EEEECCCHHHCCHHH	60.71	24489116
39	Ubiquitination	KLHLKDNKEQVDFDE EEEECCCHHHCCHHH	60.71	23749301
50	Acetylation	DFDEFANKYVPTLKN CHHHHHHHHCCCCCC	44.17	24489116
62	Ubiquitination	LKNGAQFKLSPYLFT CCCCCEEECCHHHHH	35.65	17644757
84	Ubiquitination	LGAADFSKKFPVFYG HCHHCHHHHCCEEEC	59.43	17644757
85	Ubiquitination	GAADFSKKFPVFYGR CHHCHHHHCCEEECC	54.42	23749301
96	Ubiquitination	FYGREIVKFSDGGVC EECCEEEEECCCCEE	44.82	17644757
113	Ubiquitination	DWLIDSWKKDYEFDQ HHHHHHHHHCCCCCC	39.45	17644757
114	Ubiquitination	WLIDSWKKDYEFDQS HHHHHHHHCCCCCCC	60.32	23749301
116	Phosphorylation	IDSWKKDYEFDQSTT HHHHHHCCCCCCCCC	27.63	21126336
127	Ubiquitination	QSTTSFDKKKFDKDE CCCCCCCHHHCCCCC	56.72	17644757
127	Acetylation	QSTTSFDKKKFDKDE CCCCCCCHHHCCCCC	56.72	24489116
128	Ubiquitination	STTSFDKKKFDKDEK CCCCCCHHHCCCCCC	61.59	17644757
153	Acetylation	QPRTRYLKDNELEEL CCCCEECCCCHHHHH	49.96	24489116
153	Ubiquitination	QPRTRYLKDNELEEL CCCCEECCCCHHHHH	49.96	17644757
240	Ubiquitination	KQRHPDRKLYAVGCS HHHCCCCCCHHHHCH	53.91	17644757
263	Ubiquitination	YLGEEGDKSPLSAAA HHCCCCCCCCCHHHH	65.90	17644757
297	Ubiquitination	WSRTLFSKNIAQFLT HHHHHHHHHHHHHHH	45.07	23749301
329	Ubiquitination	PDHPPTVKNPSFYMF CCCCCCCCCCCEEEE	66.67	17644757
332	Phosphorylation	PPTVKNPSFYMFTPE CCCCCCCCEEEECHH	38.10	30377154
343	Ubiquitination	FTPENLIKAKSFKST ECHHHHHCCCCCCCC	53.58	23749301
372	Ubiquitination	PNAMEYYKAASSINR CCHHHHHHHHHHCCC	36.25	17644757
409	Acetylation	QPYSIVEKNPRILYC CCCCHHHCCCCEEEE	62.45	24489116
409	Ubiquitination	QPYSIVEKNPRILYC CCCCHHHCCCCEEEE	62.45	23749301
429	Acetylation	GHLAYLDKDNNSWAT CCEEEEECCCCHHHH	60.81	24489116
429	Ubiquitination	GHLAYLDKDNNSWAT CCEEEEECCCCHHHH	60.81	17644757
437	Ubiquitination	DNNSWATKAIAEFFT CCCHHHHHHHHHHHH	30.01	24961812
437	Acetylation	DNNSWATKAIAEFFT CCCHHHHHHHHHHHH	30.01	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCFS2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCFS2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCFS2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLMT_YEAST	OPI3	genetic	16269340
AYR1_YEAST	AYR1	physical	18467557
INO1_YEAST	INO1	physical	18467557
SNA3_YEAST	SNA3	physical	18467557
ALO_YEAST	ALO1	physical	18467557
PPZ1_YEAST	PPZ1	physical	18467557
VATD_YEAST	VMA8	physical	18467557
ENG2_YEAST	ACF2	physical	18467557
ERG7_YEAST	ERG7	physical	18467557
KES1_YEAST	KES1	physical	18467557
TCD1_YEAST	TCD1	physical	18467557
GDI1_YEAST	GDI1	physical	18467557
YEH1_YEAST	YEH1	physical	18467557
TOM20_YEAST	TOM20	physical	18467557
TGL1_YEAST	TGL1	physical	18467557
MGLL_YEAST	YJU3	physical	18467557
MCFS2_YEAST	EHT1	physical	22940862
RV161_YEAST	RVS161	genetic	23891562
MCFS2_YEAST	EHT1	physical	25308280
STB5_YEAST	STB5	genetic	27708008
AP2S_YEAST	APS2	genetic	27708008
SST2_YEAST	SST2	genetic	27708008
BUL2_YEAST	BUL2	genetic	27708008
FYV12_YEAST	FYV12	genetic	27708008
KAR3_YEAST	KAR3	genetic	27708008
PRAF1_HUMAN	RABAC1	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.