| UniProt ID | ERG7_YEAST | |
|---|---|---|
| UniProt AC | P38604 | |
| Protein Name | Lanosterol synthase | |
| Gene Name | ERG7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 731 | |
| Subcellular Localization |
Lipid droplet. Endoplasmic reticulum membrane Peripheral membrane protein. Predominantly in lipid particles. |
|
| Protein Description | Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.. | |
| Protein Sequence | MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQPHPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEIPEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARSTLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYIPVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANSLVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEAFQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKFLCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHMISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGNIMVEYPYVECTDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALEALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALIALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALGMYSRAYETHTL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MTEFYSDTI ------CCCCCCCCC | 34.50 | - | |
| 13 | Ubiquitination | SDTIGLPKTDPRLWR CCCCCCCCCCHHHHC | 71.28 | 19722269 | |
| 23 | Phosphorylation | PRLWRLRTDELGRES HHHHCCCCCCCCCCC | 38.12 | 27214570 | |
| 268 | Acetylation | LRNEIYTKPFDKINF HHHHHCCCCCCCCCC | 27.07 | 24489116 | |
| 272 | Acetylation | IYTKPFDKINFSKNR HCCCCCCCCCCCCCC | 39.67 | 24489116 | |
| 628 | Ubiquitination | FLVSKQMKDGGWGES EEEEECCCCCCCCCC | 51.21 | 23749301 | |
| 670 | Ubiquitination | LFAEYPNKEVIDRGI HHHHCCCHHHHHHHH | 49.18 | 19722269 | |
| 728 | Phosphorylation | MYSRAYETHTL---- CCCCCCCCCCC---- | 13.90 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERG7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERG7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERG7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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