TOA1_YEAST - dbPTM
TOA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TOA1_YEAST
UniProt AC P32773
Protein Name Transcription initiation factor IIA large subunit
Gene Name TOA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 286
Subcellular Localization Cytoplasm . Nucleus . Imported to nucleus via interaction with KAP122.
Protein Description TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein)..
Protein Sequence MSNAEASRVYEIIVESVVNEVREDFENAGIDEQTLQDLKNIWQKKLTETKVTTFSWDNQFNEGNINGVQNDLNFNLATPGVNSSEFNIKEENTGNEGLILPNINSNNNIPHSGETNINTNTVEATNNSGATLNTNTSGNTNADVTSQPKIEVKPEIELTINNANITTVENIDDESEKKDDEEKEEDVEKTRKEKEQIEQVKLQAKKEKRSALLDTDEVGSELDDSDDDYLISEGEEDGPDENLMLCLYDKVTRTKARWKCSLKDGVVTINRNDYTFQKAQVEAEWV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
201AcetylationKEQIEQVKLQAKKEK
HHHHHHHHHHHHHHH
34.2825381059
210PhosphorylationQAKKEKRSALLDTDE
HHHHHHHHHHCCCCC
34.0419823750
215PhosphorylationKRSALLDTDEVGSEL
HHHHHCCCCCCCCCC
33.7519823750
220PhosphorylationLDTDEVGSELDDSDD
CCCCCCCCCCCCCCC
39.9119823750
225PhosphorylationVGSELDDSDDDYLIS
CCCCCCCCCCCEEEC
42.4819823750
229PhosphorylationLDDSDDDYLISEGEE
CCCCCCCEEECCCCC
16.9621551504
232PhosphorylationSDDDYLISEGEEDGP
CCCCEEECCCCCCCC
36.6328889911
263UbiquitinationARWKCSLKDGVVTIN
CEEEEEECCCEEEEE
35.8223749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TOA1_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TOA1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TOA1_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
T2AG_YEASTTOA2physical
11805826
TBP_YEASTSPT15physical
11223526
TF2B_YEASTSUA7physical
11223526
T2AG_YEASTTOA2physical
11223526
TAF11_YEASTTAF11physical
11238911
TBP_YEASTSPT15physical
12972251
TBP_YEASTSPT15physical
12527429
T2AG_YEASTTOA2physical
7862117
T2AG_YEASTTOA2physical
10675336
T2AG_YEASTTOA2physical
8657139
T2AG_YEASTTOA2genetic
10525531
MOT1_YEASTMOT1genetic
8972209
SPT3_YEASTSPT3genetic
8972209
AP1_YEASTYAP1physical
16835452
HMO1_YEASTHMO1genetic
18187511
T2AG_YEASTTOA2physical
18719252
T2AG_YEASTTOA2physical
20826334
SPR3_YEASTSPR3physical
22875988
DBP5_YEASTDBP5genetic
22963203
T2AG_YEASTTOA2physical
23814059
TAF4_YEASTTAF4physical
23814059
PDC2_YEASTPDC2genetic
27708008
COPB2_YEASTSEC27genetic
27708008
CDC12_YEASTCDC12genetic
27708008
CDC11_YEASTCDC11genetic
27708008
RPC6_YEASTRPC34genetic
27708008
SEC23_YEASTSEC23genetic
27708008
CDC24_YEASTCDC24genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
ALG14_YEASTALG14genetic
27708008
CKS1_YEASTCKS1genetic
27708008
SLI15_YEASTSLI15genetic
27708008
MED8_YEASTMED8genetic
27708008
TAF5_YEASTTAF5genetic
27708008
MCM7_YEASTMCM7genetic
27708008
CDC7_YEASTCDC7genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
TIM22_YEASTTIM22genetic
27708008
PSF1_YEASTPSF1genetic
27708008
FAL1_YEASTFAL1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
STN1_YEASTSTN1genetic
27708008
SLU7_YEASTSLU7genetic
27708008
TAF12_YEASTTAF12genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SLD5_YEASTSLD5genetic
27708008
SMC1_YEASTSMC1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
TAF6_YEASTTAF6genetic
27708008
SLD3_YEASTSLD3genetic
27708008
MCE1_YEASTCEG1genetic
27708008
GPI10_YEASTGPI10genetic
27708008
SWC4_YEASTSWC4genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
SYYC_YEASTTYS1genetic
27708008
CP51_YEASTERG11genetic
27708008
MPPA_YEASTMAS2genetic
27708008
YHS2_YEASTCIA2genetic
27708008
PRI1_YEASTPRI1genetic
27708008
PSF2_YEASTPSF2genetic
27708008
ARP4_YEASTARP4genetic
27708008
DPB11_YEASTDPB11genetic
27708008
KTHY_YEASTCDC8genetic
27708008
SSL1_YEASTSSL1genetic
27708008
SMC4_YEASTSMC4genetic
27708008
CDC45_YEASTCDC45genetic
27708008
MCM5_YEASTMCM5genetic
27708008
STT4_YEASTSTT4genetic
27708008
TAD3_YEASTTAD3genetic
27708008
SEC39_YEASTSEC39genetic
27708008
TAF11_YEASTTAF11genetic
27708008
BET5_YEASTBET5genetic
27708008
TAF13_YEASTTAF13genetic
27708008
TAF8_YEASTTAF8genetic
27708008
RSC9_YEASTRSC9genetic
27708008
TAF4_YEASTTAF4genetic
27708008
ARP9_YEASTARP9genetic
27708008
PDS5_YEASTPDS5genetic
27708008
MED11_YEASTMED11genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
TAF7_YEASTTAF7genetic
27708008
LIP1_YEASTLIP1genetic
27708008
DPOA_YEASTPOL1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
SEC12_YEASTSEC12genetic
27708008
MOT1_YEASTMOT1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
NSL1_YEASTNSL1genetic
27708008
ARP7_YEASTARP7genetic
27708008
TF2B_YEASTSUA7genetic
27708008
SWC3_YEASTSWC3genetic
27708008
SWD1_YEASTSWD1genetic
27708008
RKM3_YEASTRKM3genetic
27708008
MUM2_YEASTMUM2genetic
27708008
AIM4_YEASTAIM4genetic
27708008
MET8_YEASTMET8genetic
27708008
CHK1_YEASTCHK1genetic
27708008
ELO2_YEASTELO2genetic
27708008
PAT1_YEASTPAT1genetic
27708008
SWR1_YEASTSWR1genetic
27708008
ERD1_YEASTERD1genetic
27708008
VPS72_YEASTVPS72genetic
27708008
URC2_YEASTURC2genetic
27708008
KA122_YEASTKAP122genetic
27708008
AIM14_YEASTAIM14genetic
27708008
ELP2_YEASTELP2genetic
27708008
SNF6_YEASTSNF6genetic
27708008
YHJ5_YEASTNEL1genetic
27708008
STB5_YEASTSTB5genetic
27708008
ACA2_YEASTCST6genetic
27708008
LSM1_YEASTLSM1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
SAC1_YEASTSAC1genetic
27708008
ARP6_YEASTARP6genetic
27708008
VPS71_YEASTVPS71genetic
27708008
LSM7_YEASTLSM7genetic
27708008
BRE5_YEASTBRE5genetic
27708008
YP039_YEASTYPL039Wgenetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
ELOC_YEASTELC1genetic
27708008
PDR12_YEASTPDR12genetic
27708008
ALDH6_YEASTALD6genetic
27708008
CWC27_YEASTCWC27genetic
27708008
YP068_YEASTYPL068Cgenetic
27708008
YP071_YEASTYPL071Cgenetic
27708008
FMP30_YEASTFMP30genetic
27708008
BEM3_YEASTBEM3genetic
27708008
MEI5_YEASTMEI5genetic
27708008
RNY1_YEASTRNY1genetic
27708008
ODC1_YEASTODC1genetic
27708008
ATG5_YEASTATG5genetic
27708008
YP162_YEASTYPL162Cgenetic
27708008
SVS1_YEASTSVS1genetic
27708008
AFT2_YEASTAFT2genetic
27708008
RU2A_YEASTLEA1genetic
27708008
YP225_YEASTYPL225Wgenetic
27708008
RBD2_YEASTRBD2genetic
27708008
SRO7_YEASTSRO7genetic
27708008
UBA3_YEASTUBA3genetic
27708008
MED1_YEASTMED1genetic
27708008
T2AG_YEASTTOA2physical
28259734

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TOA1_YEAST

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Related Literatures of Post-Translational Modification

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