| UniProt ID | TOA1_YEAST | |
|---|---|---|
| UniProt AC | P32773 | |
| Protein Name | Transcription initiation factor IIA large subunit | |
| Gene Name | TOA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 286 | |
| Subcellular Localization | Cytoplasm . Nucleus . Imported to nucleus via interaction with KAP122. | |
| Protein Description | TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein).. | |
| Protein Sequence | MSNAEASRVYEIIVESVVNEVREDFENAGIDEQTLQDLKNIWQKKLTETKVTTFSWDNQFNEGNINGVQNDLNFNLATPGVNSSEFNIKEENTGNEGLILPNINSNNNIPHSGETNINTNTVEATNNSGATLNTNTSGNTNADVTSQPKIEVKPEIELTINNANITTVENIDDESEKKDDEEKEEDVEKTRKEKEQIEQVKLQAKKEKRSALLDTDEVGSELDDSDDDYLISEGEEDGPDENLMLCLYDKVTRTKARWKCSLKDGVVTINRNDYTFQKAQVEAEWV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 201 | Acetylation | KEQIEQVKLQAKKEK HHHHHHHHHHHHHHH | 34.28 | 25381059 | |
| 210 | Phosphorylation | QAKKEKRSALLDTDE HHHHHHHHHHCCCCC | 34.04 | 19823750 | |
| 215 | Phosphorylation | KRSALLDTDEVGSEL HHHHHCCCCCCCCCC | 33.75 | 19823750 | |
| 220 | Phosphorylation | LDTDEVGSELDDSDD CCCCCCCCCCCCCCC | 39.91 | 19823750 | |
| 225 | Phosphorylation | VGSELDDSDDDYLIS CCCCCCCCCCCEEEC | 42.48 | 19823750 | |
| 229 | Phosphorylation | LDDSDDDYLISEGEE CCCCCCCEEECCCCC | 16.96 | 21551504 | |
| 232 | Phosphorylation | SDDDYLISEGEEDGP CCCCEEECCCCCCCC | 36.63 | 28889911 | |
| 263 | Ubiquitination | ARWKCSLKDGVVTIN CEEEEEECCCEEEEE | 35.82 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TOA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TOA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TOA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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