AFT2_YEAST - dbPTM
AFT2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AFT2_YEAST
UniProt AC Q08957
Protein Name Iron-regulated transcriptional activator AFT2
Gene Name AFT2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 416
Subcellular Localization Nucleus .
Protein Description Transcription factor required for iron homeostasis and resistance to oxidative stress. With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon..
Protein Sequence MKAKSMKSIISVPISVSKTGKMKLTASPDNLASMMSKDQNKLIHLDPVPSFEDRHEIKPWLQKIFYPQGIDIVIERSDSSKVTFKCRSVRSKVGLNPKSKGSSSRSHACPFRIRAAYSVRLQKWNVVVMNNIHSHELRFDLITKTDDYKKFKENLRQKNDEKAIKTFDELEYKASLNLPLVTPIISCDCGLTKEIEAFNNIFLPLSNPPLTSKKNLLKTNKNSVSKIKSRQMDNSKPRPRLKTKLDADLHDTGFLDNFKTRNSCVKIEKEDSLTNLNEIDFTNMFCNDNFIQNYNQGLMELLTEPTPGPSSSSCILPSTPTRPLSQSKMDIALSESTTSSPNFMETDAPYGDEIIKVSKDTKSNAPTADTDIATNLGKERNENFGMLNYNYEALLHFNDEHFNELNSIDPALISKY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMKAKSMKSIISVPIS
CCCCCCCEEEEEEEE		19.2627017623
25PhosphorylationKTGKMKLTASPDNLA
CCCCEEEEECHHHHH		21.4128889911
33PhosphorylationASPDNLASMMSKDQN
ECHHHHHHHHCCCCC		20.4128889911
36PhosphorylationDNLASMMSKDQNKLI
HHHHHHHCCCCCCCC		25.1628889911
337PhosphorylationDIALSESTTSSPNFM
EEEECCCCCCCCCCC		27.0121551504
338PhosphorylationIALSESTTSSPNFME
EEECCCCCCCCCCCC		36.1621551504
339PhosphorylationALSESTTSSPNFMET
EECCCCCCCCCCCCC		43.8427017623
340PhosphorylationLSESTTSSPNFMETD
ECCCCCCCCCCCCCC		23.0527017623
350PhosphorylationFMETDAPYGDEIIKV
CCCCCCCCCCEEEEE		38.6427017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AFT2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AFT2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AFT2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CP56_YEASTDIT2genetic
20093466
ODPA_YEASTPDA1genetic
20093466
MSH4_YEASTMSH4genetic
20093466
DHOM_YEASTHOM6genetic
20093466
XDJ1_YEASTXDJ1genetic
20093466
MSB4_YEASTMSB4genetic
20093466
MMS22_YEASTMMS22genetic
20439772
MED1_YEASTMED1genetic
20439772
DCAM_YEASTSPE2genetic
20439772
MIT1_YEASTMIT1genetic
20439772
ZAP1_YEASTZAP1genetic
20959818
MET32_YEASTMET32genetic
20959818
URE2_YEASTURE2genetic
20959818
TBCC_YEASTCIN2genetic
20959818
CG11_YEASTCLN1genetic
21127252
AFT1_YEASTAFT1genetic
21127252
HAL4_YEASTSAT4genetic
21127252
PLM2_YEASTPLM2genetic
21127252
AFT2_YEASTAFT2physical
24591629
MGR1_YEASTMGR1genetic
27708008
XRS2_YEASTXRS2genetic
27708008
CP56_YEASTDIT2genetic
27708008
ODPA_YEASTPDA1genetic
27708008
MSH4_YEASTMSH4genetic
27708008
DHOM_YEASTHOM6genetic
27708008
TMA23_YEASTTMA23genetic
27708008
OCA2_YEASTOCA2genetic
27708008
NST1_YEASTNST1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AFT2_YEAST

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Related Literatures of Post-Translational Modification

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