| UniProt ID | AFT1_YEAST | |
|---|---|---|
| UniProt AC | P22149 | |
| Protein Name | Iron-regulated transcriptional activator AFT1 | |
| Gene Name | AFT1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 690 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Probable transcription factor that activates the genes for FRE1, FRE2 and FET3 in response to iron deprivation. [PubMed: 7720713] | |
| Protein Sequence | MEGFNPADIEHASPINSSDSHSSSFVYALPKSASEYVVNHNEGRASASGNPAAVPSPIMTLNLKSTHSLNIDQHVHTSTSPTETIGHIHHVEKLNQNNLIHLDPVPNFEDKSDIKPWLQKIFYPQGIELVIERSDAFKVVFKCKAAKRGRNARRKRKDKPKGQDHEDEKSKINDDELEYASPSNATVTNGPQTSPDQTSSIKPKKKRCVSRFNNCPFRVRATYSLKRKRWSIVVMDNNHSHQLKFNPDSEEYKKFKEKLRKDNDVDAIKKFDELEYRTLANLPIPTATIPCDCGLTNEIQSFNVVLPTNSNVTSSASSSTVSSISLDSSNASKRPCLPSVNNTGSINTNNVRKPKSQCKNKDTLLKRTTMQNFLTTKSRLRKTGTPTSSQHSSTAFSGYIDDPFNLNEILPLPASDFKLNTVTNLNEIDFTNIFTKSPHPHSGSTHPRQVFDQLDDCSSILFSPLTTNTNNEFEGESDDFVHSPYLNSEADFSQILSSAPPVHHDPNETHQENQDIIDRFANSSQEHNEYILQYLTHSDAANHNNIGVPNNNSHSLNTQHNVSDLGNSLLRQEALVGSSSTKIFDELKFVQNGPHGSQHPIDFQHVDHRHLSSNEPQVRSHQYGPQQQPPQQLQYHQNQPHDGHNHEQHQTVQKDMQTHESLEIMGNTLLEEFKDIKMVNGELKYVKPED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | PADIEHASPINSSDS HHHCCCCCCCCCCCC | 28.37 | 24961812 | |
| 17 | Phosphorylation | EHASPINSSDSHSSS CCCCCCCCCCCCCCC | 35.92 | 30377154 | |
| 18 | Phosphorylation | HASPINSSDSHSSSF CCCCCCCCCCCCCCE | 38.35 | 30377154 | |
| 56 | Phosphorylation | GNPAAVPSPIMTLNL CCCCCCCCCEEEEEC | 22.06 | 25752575 | |
| 77 | Phosphorylation | NIDQHVHTSTSPTET CCCCEEECCCCCCCC | 32.39 | 24961812 | |
| 78 | Phosphorylation | IDQHVHTSTSPTETI CCCEEECCCCCCCCC | 16.41 | 24961812 | |
| 79 | Phosphorylation | DQHVHTSTSPTETIG CCEEECCCCCCCCCC | 39.62 | 24961812 | |
| 80 | Phosphorylation | QHVHTSTSPTETIGH CEEECCCCCCCCCCC | 29.59 | 24961812 | |
| 82 | Phosphorylation | VHTSTSPTETIGHIH EECCCCCCCCCCCHH | 45.59 | 24961812 | |
| 84 | Phosphorylation | TSTSPTETIGHIHHV CCCCCCCCCCCHHCH | 34.43 | 24961812 | |
| 181 | Phosphorylation | DDELEYASPSNATVT HHHCCCCCCCCCEEC | 28.14 | 20377248 | |
| 183 | Phosphorylation | ELEYASPSNATVTNG HCCCCCCCCCEECCC | 36.28 | 20377248 | |
| 186 | Phosphorylation | YASPSNATVTNGPQT CCCCCCCEECCCCCC | 31.92 | 24961812 | |
| 188 | Phosphorylation | SPSNATVTNGPQTSP CCCCCEECCCCCCCC | 30.06 | 19779198 | |
| 193 | Phosphorylation | TVTNGPQTSPDQTSS EECCCCCCCCCCCCC | 45.41 | 28889911 | |
| 194 | Phosphorylation | VTNGPQTSPDQTSSI ECCCCCCCCCCCCCC | 22.64 | 20377248 | |
| 198 | Phosphorylation | PQTSPDQTSSIKPKK CCCCCCCCCCCCCCC | 31.64 | 24961812 | |
| 199 | Phosphorylation | QTSPDQTSSIKPKKK CCCCCCCCCCCCCCC | 25.16 | 21440633 | |
| 200 | Phosphorylation | TSPDQTSSIKPKKKR CCCCCCCCCCCCCCH | 37.71 | 24961812 | |
| 210 | Phosphorylation | PKKKRCVSRFNNCPF CCCCHHHHCCCCCCC | 34.48 | 28889911 | |
| 224 | Phosphorylation | FRVRATYSLKRKRWS CEEEEEEECCCCEEE | 24.06 | 28889911 | |
| 231 | Phosphorylation | SLKRKRWSIVVMDNN ECCCCEEEEEEECCC | 14.99 | 24961812 | |
| 368 | Phosphorylation | KDTLLKRTTMQNFLT HHHHHHHHHHHHHHH | 25.65 | 30377154 | |
| 369 | Phosphorylation | DTLLKRTTMQNFLTT HHHHHHHHHHHHHHH | 22.31 | 25521595 | |
| 397 | Phosphorylation | QHSSTAFSGYIDDPF CCCCCCCCCCCCCCC | 28.37 | 21440633 | |
| 578 | Phosphorylation | RQEALVGSSSTKIFD HHHHHHCCCCCHHHH | 17.40 | 22369663 | |
| 579 | Phosphorylation | QEALVGSSSTKIFDE HHHHHCCCCCHHHHH | 35.78 | 22369663 | |
| 580 | Phosphorylation | EALVGSSSTKIFDEL HHHHCCCCCHHHHHE | 35.10 | 22369663 | |
| 581 | Phosphorylation | ALVGSSSTKIFDELK HHHCCCCCHHHHHEE | 30.06 | 22369663 | |
| 612 | Phosphorylation | HVDHRHLSSNEPQVR CCCCCCCCCCCCCHH | 25.62 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AFT1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AFT1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AFT1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-193, AND MASSSPECTROMETRY. | |
