dbPTM

VPS4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VPS4_YEAST
UniProt AC	P52917
Protein Name	Vacuolar protein sorting-associated protein 4
Gene Name	VPS4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	437
Subcellular Localization	Endosome membrane Peripheral membrane protein.
Protein Description	Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex..
Protein Sequence	MSTGDFLTKGIELVQKAIDLDTATQYEEAYTAYYNGLDYLMLALKYEKNPKSKDLIRAKFTEYLNRAEQLKKHLESEEANAAKKSPSAGSGSNGGNKKISQEEGEDNGGEDNKKLRGALSSAILSEKPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFIDEVDALTGTRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSAIRRRFERRIYIPLPDLAARTTMFEINVGDTPCVLTKEDYRTLGAMTEGYSGSDIAVVVKDALMQPIRKIQSATHFKDVSTEDDETRKLTPCSPGDDGAIEMSWTDIEADELKEPDLTIKDFLKAIKSTRPTVNEDDLLKQEQFTRDFGQEGN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTGDFLTK ------CCCHHHHHH	40.89	21126336
59	Ubiquitination	SKDLIRAKFTEYLNR CHHHHHHHHHHHHHH	42.86	23749301
76	Phosphorylation	QLKKHLESEEANAAK HHHHHHHHHHHHHHH	47.28	22369663
85	Phosphorylation	EANAAKKSPSAGSGS HHHHHHHCCCCCCCC	24.31	22369663
87	Phosphorylation	NAAKKSPSAGSGSNG HHHHHCCCCCCCCCC	52.96	22369663
90	Phosphorylation	KKSPSAGSGSNGGNK HHCCCCCCCCCCCCC	38.47	22369663
92	Phosphorylation	SPSAGSGSNGGNKKI CCCCCCCCCCCCCCC	33.72	22369663
100	Phosphorylation	NGGNKKISQEEGEDN CCCCCCCCHHHCCCC	40.18	28889911
120	Phosphorylation	KKLRGALSSAILSEK HHHHHHHHHHHHCCC	19.72	17330950
121	Phosphorylation	KLRGALSSAILSEKP HHHHHHHHHHHCCCC	21.85	25752575
125	Phosphorylation	ALSSAILSEKPNVKW HHHHHHHCCCCCCCH	37.14	27017623
154	Acetylation	EAVILPVKFPHLFKG HCCEEECCCCCCCCC	51.76	24489116
160	Acetylation	VKFPHLFKGNRKPTS CCCCCCCCCCCCCCC	62.73	24489116
212	Acetylation	KWMGESEKLVKQLFA HHHCCHHHHHHHHHH	68.79	24489116
356	Phosphorylation	QPIRKIQSATHFKDV HHHHHHHCCCCCCCC	38.31	21440633
358	Phosphorylation	IRKIQSATHFKDVST HHHHHCCCCCCCCCC	32.85	27717283
361	Acetylation	IQSATHFKDVSTEDD HHCCCCCCCCCCCCC	50.01	24489116
424	Acetylation	VNEDDLLKQEQFTRD CCHHHHHHHHHHHHH	60.12	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VPS4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VPS4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VPS4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRO1_YEAST	BRO1	physical	11805826
SNF7_YEAST	SNF7	physical	11805826
SNF7_YEAST	SNF7	physical	10688190
VPS20_YEAST	VPS20	physical	12953057
VTA1_YEAST	VTA1	physical	12953057
SNF7_YEAST	SNF7	physical	15086794
VTA1_YEAST	VTA1	physical	15086794
PALA_YEAST	RIM20	physical	15086794
DID2_YEAST	DID2	physical	15086794
YBI1_YEAST	YBL081W	physical	16554755
IF5A1_YEAST	HYP2	physical	16554755
SSZ1_YEAST	SSZ1	physical	16554755
LSM12_YEAST	LSM12	physical	16554755
HS104_YEAST	HSP104	physical	16554755
SNF7_YEAST	SNF7	physical	16554755
EF3A_YEAST	YEF3	physical	16554755
IST1_YEAST	IST1	physical	16554755
LSP1_YEAST	LSP1	physical	16554755
VPS4_YEAST	VPS4	physical	16193069
DID2_YEAST	DID2	physical	16601096
OSH6_YEAST	OSH6	physical	16096648
OSH7_YEAST	OSH7	physical	16096648
VPS20_YEAST	VPS20	physical	16704411
VTA1_YEAST	VTA1	physical	16704411
DID2_YEAST	DID2	physical	16704411
VPS4_YEAST	VPS4	physical	16704411
COPE_YEAST	SEC28	genetic	16269340
PFD2_YEAST	GIM4	genetic	16269340
SEC63_YEAST	SEC63	genetic	16269340
OSTB_YEAST	WBP1	genetic	16269340
UPPS_YEAST	NUS1	genetic	16269340
SHR3_YEAST	SHR3	genetic	16269340
SNF7_YEAST	SNF7	physical	11283351
VPS4_YEAST	VPS4	physical	17949747
DID2_YEAST	DID2	physical	17928861
DID4_YEAST	DID4	physical	17928861
VTA1_YEAST	VTA1	physical	18280501
IST1_YEAST	IST1	physical	18032584
VPS4_YEAST	VPS4	physical	18272179
VPS4_YEAST	VPS4	physical	18929572
ADA2_YEAST	ADA2	physical	18719252
SMY1_YEAST	SMY1	genetic	19547744
DID4_YEAST	DID4	physical	19234443
VPS24_YEAST	VPS24	physical	19234443
TPS1_YEAST	TPS1	genetic	20093466
SEC66_YEAST	SEC66	genetic	20093466
SWC5_YEAST	SWC5	genetic	20093466
AP3M_YEAST	APM3	genetic	20093466
VAC17_YEAST	VAC17	genetic	20093466
BUD31_YEAST	BUD31	genetic	20093466
LRG1_YEAST	LRG1	genetic	20093466
UBX3_YEAST	UBX3	genetic	20093466
ODO2_YEAST	KGD2	genetic	20093466
SAC3_YEAST	SAC3	genetic	20093466
NBP2_YEAST	NBP2	genetic	20093466
BCS1_YEAST	BCS1	genetic	20093466
RLA4_YEAST	RPP2B	genetic	20093466
PT122_YEAST	PET122	genetic	20093466
VAM7_YEAST	VAM7	genetic	20093466
ATG1_YEAST	ATG1	genetic	20093466
HUR1_YEAST	HUR1	genetic	20093466
ATC1_YEAST	PMR1	genetic	20093466
MON1_YEAST	MON1	genetic	20093466
PALF_YEAST	RIM8	genetic	20093466
YG34_YEAST	YGR122W	genetic	20093466
AP3B_YEAST	APL6	genetic	20093466
THP2_YEAST	THP2	genetic	20093466
APQ12_YEAST	APQ12	genetic	20093466
MOG1_YEAST	MOG1	genetic	20093466
ELM1_YEAST	ELM1	genetic	20093466
VPS24_YEAST	VPS24	genetic	20093466
TUL1_YEAST	TUL1	genetic	20093466
COX12_YEAST	COX12	genetic	20093466
RIC1_YEAST	RIC1	genetic	20093466
ARP6_YEAST	ARP6	genetic	20093466
SRN2_YEAST	SRN2	genetic	20093466
DCR2_YEAST	DCR2	genetic	20093466
SST2_YEAST	SST2	genetic	20093466
PKR1_YEAST	PKR1	genetic	20093466
PO152_YEAST	POM152	genetic	20093466
RIM13_YEAST	RIM13	genetic	20093466
EOS1_YEAST	EOS1	genetic	20093466
HDA1_YEAST	HDA1	genetic	20093466
YO073_YEAST	DSC2	genetic	20093466
PHO80_YEAST	PHO80	genetic	20093466
VHS3_YEAST	VHS3	genetic	20093466
ODC2_YEAST	ODC2	genetic	20093466
YO223_YEAST	DSC3	genetic	20093466
MCP1_YEAST	MCP1	genetic	20093466
VPH1_YEAST	VPH1	genetic	20093466
THP3_YEAST	THP3	genetic	20093466
DID2_YEAST	DID2	genetic	20110351
DID4_YEAST	DID4	genetic	20110351
VPS24_YEAST	VPS24	genetic	20110351
IST1_YEAST	IST1	genetic	20110351
SNF7_YEAST	SNF7	genetic	20110351
VPS20_YEAST	VPS20	genetic	20110351
DID2_YEAST	DID2	genetic	18032582
DID4_YEAST	DID4	genetic	18032582
DID2_YEAST	DID2	physical	18266866
VTA1_YEAST	VTA1	physical	18266866
DID4_YEAST	DID4	physical	18266866
VPS20_YEAST	VPS20	physical	18266866
BRO1_YEAST	BRO1	physical	18266866
SNF7_YEAST	SNF7	physical	18266866
WHI2_YEAST	WHI2	genetic	20526336
KC13_YEAST	YCK3	genetic	20526336
CARP_YEAST	PEP4	genetic	18794364
SRS2_YEAST	SRS2	genetic	21459050
STP22_YEAST	STP22	genetic	21505419
SSO1_YEAST	SSO1	genetic	21784249
SSO2_YEAST	SSO2	genetic	21784249
VPS20_YEAST	VPS20	physical	22875988
VPS21_YEAST	VPS21	genetic	22899724
VPS4_YEAST	VPS4	physical	23913684
PFD2_YEAST	GIM4	genetic	23891562
VPS4_YEAST	VPS4	physical	24161953
VTA1_YEAST	VTA1	physical	24161953
ELM1_YEAST	ELM1	genetic	22282571
ATG1_YEAST	ATG1	genetic	22282571
BRO1_YEAST	BRO1	physical	15086794
SNF7_YEAST	SNF7	physical	24711499
VPS24_YEAST	VPS24	physical	24711499
DID4_YEAST	DID4	physical	24711499
VPS20_YEAST	VPS20	physical	24711499
DID2_YEAST	DID2	physical	24711499
VPS9_YEAST	VPS9	genetic	25673804
VFA1_YEAST	VFA1	physical	24567329
IST1_YEAST	IST1	physical	26515066
THRC_YEAST	THR4	genetic	27708008
PALF_YEAST	RIM8	genetic	27708008
VPS24_YEAST	VPS24	genetic	27708008
SRN2_YEAST	SRN2	genetic	27708008
PALI_YEAST	RIM9	genetic	27708008
VPS27_YEAST	VPS27	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
CKS1_YEAST	CKS1	genetic	27708008
MCM7_YEAST	MCM7	genetic	27708008
COPA_YEAST	COP1	genetic	27708008
GLE1_YEAST	GLE1	genetic	27708008
UBC3_YEAST	CDC34	genetic	27708008
SC61G_YEAST	SSS1	genetic	27708008
SEC7_YEAST	SEC7	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
COPD_YEAST	RET2	genetic	27708008
USE1_YEAST	USE1	genetic	27708008
TEL2_YEAST	TEL2	genetic	27708008
RPF2_YEAST	RPF2	genetic	27708008
SED5_YEAST	SED5	genetic	27708008
SC61A_YEAST	SEC61	genetic	27708008
VTI1_YEAST	VTI1	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
RPC6_YEAST	RPC34	genetic	27708008
SEC63_YEAST	SEC63	genetic	27708008
COPZ_YEAST	RET3	genetic	27708008
ULP1_YEAST	ULP1	genetic	27708008
MOT1_YEAST	MOT1	genetic	27708008
NAB3_YEAST	NAB3	genetic	27708008
TPS1_YEAST	TPS1	genetic	27708008
CCZ1_YEAST	CCZ1	genetic	27708008
SEC66_YEAST	SEC66	genetic	27708008
SWC5_YEAST	SWC5	genetic	27708008
AP3M_YEAST	APM3	genetic	27708008
BUD31_YEAST	BUD31	genetic	27708008
RXT3_YEAST	RXT3	genetic	27708008
VAM6_YEAST	VAM6	genetic	27708008
UBX3_YEAST	UBX3	genetic	27708008
VPS41_YEAST	VPS41	genetic	27708008
RM01_YEAST	MRPL1	genetic	27708008
SAC3_YEAST	SAC3	genetic	27708008
NBP2_YEAST	NBP2	genetic	27708008
RLA4_YEAST	RPP2B	genetic	27708008
SAC7_YEAST	SAC7	genetic	27708008
PT122_YEAST	PET122	genetic	27708008
MON1_YEAST	MON1	genetic	27708008
ATC1_YEAST	PMR1	genetic	27708008
HUR1_YEAST	HUR1	genetic	27708008
COM1_YEAST	SAE2	genetic	27708008
DSD1_YEAST	DSD1	genetic	27708008
CBP4_YEAST	CBP4	genetic	27708008
AP3B_YEAST	APL6	genetic	27708008
RS27B_YEAST	RPS27B	genetic	27708008
SLT2_YEAST	SLT2	genetic	27708008
PUT2_YEAST	PUT2	genetic	27708008
COX23_YEAST	COX23	genetic	27708008
THP2_YEAST	THP2	genetic	27708008
STB5_YEAST	STB5	genetic	27708008
AP3S_YEAST	APS3	genetic	27708008
RCY1_YEAST	RCY1	genetic	27708008
MOG1_YEAST	MOG1	genetic	27708008
HOC1_YEAST	HOC1	genetic	27708008
TUL1_YEAST	TUL1	genetic	27708008
ELM1_YEAST	ELM1	genetic	27708008
COX12_YEAST	COX12	genetic	27708008
RIC1_YEAST	RIC1	genetic	27708008
PFD6_YEAST	YKE2	genetic	27708008
DCR2_YEAST	DCR2	genetic	27708008
PKR1_YEAST	PKR1	genetic	27708008
PO152_YEAST	POM152	genetic	27708008
RIM13_YEAST	RIM13	genetic	27708008
HDA1_YEAST	HDA1	genetic	27708008
SWS2_YEAST	SWS2	genetic	27708008
BRE5_YEAST	BRE5	genetic	27708008
PHO80_YEAST	PHO80	genetic	27708008
YO036_YEAST	YOL036W	genetic	27708008
YO073_YEAST	DSC2	genetic	27708008
VPS68_YEAST	VPS68	genetic	27708008
VHS3_YEAST	VHS3	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008
COQ7_YEAST	CAT5	genetic	27708008
YO223_YEAST	DSC3	genetic	27708008
MCP1_YEAST	MCP1	genetic	27708008
OXR1_YEAST	OXR1	genetic	27708008
YJE9_YEAST	YJL049W	genetic	27733427
DID4_YEAST	DID4	physical	25833946
TRI39_HUMAN	TRIM39	physical	27107014
UBX11_HUMAN	UBXN11	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VPS4_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100 AND SER-120, ANDMASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, AND MASSSPECTROMETRY.	17563356 [Abstract]