| UniProt ID | ODC2_YEAST | |
|---|---|---|
| UniProt AC | Q99297 | |
| Protein Name | Mitochondrial 2-oxodicarboxylate carrier 2 | |
| Gene Name | ODC2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 307 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein. |
|
| Protein Description | Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.. | |
| Protein Sequence | MSSDSNAKPLPFIYQFISGAVAGISELTVMYPLDVVKTRFQLEVTTPTAAAVGKQVERYNGVIDCLKKIVKKEGFSRLYRGISSPMLMEAPKRATKFACNDQYQKIFKNLFNTNETTQKISIAAGASAGMTEAAVIVPFELIKIRMQDVKSSYLGPMDCLKKTIKNEGIMGLYKGIESTMWRNALWNGGYFGVIYQVRNSMPVAKTKGQKTRNDLIAGAIGGTVGTMLNTPFDVVKSRIQSVDAVSSAVKKYNWCLPSLLVIYREEGFRALYKGFVPKVCRLAPGGSLMLVVFTGMMNFFRDLKYGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 83 | Phosphorylation | SRLYRGISSPMLMEA HHHHCCCCCCHHHCC | 31.08 | 30377154 | |
| 84 | Phosphorylation | RLYRGISSPMLMEAP HHHCCCCCCHHHCCC | 16.65 | 25371407 | |
| 105 | Acetylation | ACNDQYQKIFKNLFN HCCHHHHHHHHHHCC | 45.21 | 24489116 | |
| 108 | Acetylation | DQYQKIFKNLFNTNE HHHHHHHHHHCCCCC | 57.10 | 24489116 | |
| 151 | Phosphorylation | IRMQDVKSSYLGPMD EEHHHHHHHHCCHHH | 24.86 | 27017623 | |
| 163 | Phosphorylation | PMDCLKKTIKNEGIM HHHHHHHHHHHCCCC | 35.28 | 23607784 | |
| 173 | Phosphorylation | NEGIMGLYKGIESTM HCCCCHHHHHHHHHH | 11.05 | 23607784 | |
| 178 | Phosphorylation | GLYKGIESTMWRNAL HHHHHHHHHHHHHHH | 22.95 | 23607784 | |
| 179 | Phosphorylation | LYKGIESTMWRNALW HHHHHHHHHHHHHHH | 14.15 | 23607784 | |
| 287 | Phosphorylation | CRLAPGGSLMLVVFT HHCCCCCCEEEEEEC | 19.27 | 19823750 | |
| 294 | Phosphorylation | SLMLVVFTGMMNFFR CEEEEEECHHHHHHH | 16.74 | 19823750 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ODC2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ODC2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ODC2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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