YHM2_YEAST - dbPTM
YHM2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YHM2_YEAST
UniProt AC Q04013
Protein Name Citrate/oxoglutarate carrier protein {ECO:0000303|PubMed:20371607}
Gene Name YHM2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 314
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein . Mitochondrion matrix, mitochondrion nucleoid .
Protein Description Mitochondrial antiporter which catalyzes the transport of citrate and oxoglutarate across the membrane. Also shows specificity for oxaloacetate, and to a lesser extent succinate and fumarate. Transports isocitrate, cis-aconitate and L-malate with very low efficiency. Does not show uniporter activity. Helps to maintain normal citrate levels and NADPH/NADP+ ratios under conditions of oxidative stress. In addition, associates with the mitochondrial nucleoid and binds DNA in vitro, although the relevance of these data in vivo is unclear..
Protein Sequence MPSTTNTAAANVIEKKPVSFSNILLGACLNLSEVTTLGQPLEVVKTTMAANRNFTFLESVKHVWSRGGILGYYQGLIPWAWIEASTKGAVLLFVSAEAEYRFKSLGLNNFASGILGGVTGGVTQAYLTMGFCTCMKTVEITRHKSASAGGVPQSSWSVFKNIYKKEGIRGINKGVNAVAIRQMTNWGSRFGLSRLVEDGIRKITGKTNKDDKLNPFEKIGASALGGGLSAWNQPIEVIRVEMQSKKEDPNRPKNLTVGKTFKYIYQSNGLKGLYRGVTPRIGLGIWQTVFMVGFGDMAKEFVARMTGETPVAKH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationQPLEVVKTTMAANRN
CCCHHHHHHHHHCCC		15.3628889911
55PhosphorylationMAANRNFTFLESVKH
HHHCCCEEHHHHCCH		30.7528889911
61AcetylationFTFLESVKHVWSRGG
EEHHHHCCHHHHHCC		41.5424489116
95PhosphorylationGAVLLFVSAEAEYRF
CEEEEEEECCCCHHH		17.0428889911
104PhosphorylationEAEYRFKSLGLNNFA
CCCHHHHHCCCCHHC		25.5927017623
112PhosphorylationLGLNNFASGILGGVT
CCCCHHCCCHHCCCC		23.4127017623
128PhosphorylationGVTQAYLTMGFCTCM
CHHHHHHHHCCCCEE		11.5427017623
133PhosphorylationYLTMGFCTCMKTVEI
HHHHCCCCEEEEEEE		17.2427017623
144UbiquitinationTVEITRHKSASAGGV
EEEEEECCCCCCCCC		44.4117644757
160AcetylationQSSWSVFKNIYKKEG
HHHHHHHHHHHHHHC		40.0424489116
160UbiquitinationQSSWSVFKNIYKKEG
HHHHHHHHHHHHHHC		40.0417644757
173AcetylationEGIRGINKGVNAVAI
HCCCCCCCCCCCEEH		63.4224489116
206UbiquitinationGIRKITGKTNKDDKL
CHHHHHCCCCCCCCC		40.0317644757
209AcetylationKITGKTNKDDKLNPF
HHHCCCCCCCCCCHH		72.9624489116
209UbiquitinationKITGKTNKDDKLNPF
HHHCCCCCCCCCCHH		72.9617644757
212UbiquitinationGKTNKDDKLNPFEKI
CCCCCCCCCCHHHHH		61.3717644757
218UbiquitinationDKLNPFEKIGASALG
CCCCHHHHHCHHHHC		46.9817644757
245UbiquitinationIRVEMQSKKEDPNRP
EEEEECCCCCCCCCC		43.2017644757
246UbiquitinationRVEMQSKKEDPNRPK
EEEECCCCCCCCCCC		73.0117644757
259AcetylationPKNLTVGKTFKYIYQ
CCCCCCCHHHHHHHH		46.5922865919
2592-HydroxyisobutyrylationPKNLTVGKTFKYIYQ
CCCCCCCHHHHHHHH		46.59-
262AcetylationLTVGKTFKYIYQSNG
CCCCHHHHHHHHHCC		35.6524489116
271AcetylationIYQSNGLKGLYRGVT
HHHHCCCCHHHCCCC		48.5524489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YHM2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YHM2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YHM2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
G6PD_YEASTZWF1genetic
20371607
TXTP_YEASTCTP1genetic
20371607
MDM10_YEASTMDM10genetic
21987634
BEM1_YEASTBEM1genetic
21987634
ODPB_YEASTPDB1genetic
21987634
ISC1_YEASTISC1genetic
21987634
ODPA_YEASTPDA1genetic
21987634
DLDH_YEASTLPD1genetic
21987634
PT130_YEASTPET130genetic
21987634
MDM35_YEASTMDM35genetic
21987634
MMM1_YEASTMMM1genetic
21987634
UPS1_YEASTUPS1genetic
21987634
ARV1_YEASTARV1genetic
21987634
ODP2_YEASTLAT1genetic
21987634
CISY1_YEASTCIT1genetic
21987634
INO4_YEASTINO4genetic
21987634
IDH2_YEASTIDH2genetic
21987634
GEP3_YEASTGEP3genetic
21987634
MGM1_YEASTMGM1genetic
21987634
YME1_YEASTYME1genetic
21987634
SSB1_YEASTSSB1physical
22940862
MGR1_YEASTMGR1genetic
27708008
ERF3_YEASTSUP35genetic
27708008
ODPB_YEASTPDB1genetic
27708008
ODPA_YEASTPDA1genetic
27708008
DLDH_YEASTLPD1genetic
27708008
GCN20_YEASTGCN20genetic
27708008
ARO8_YEASTARO8genetic
27708008
ODPX_YEASTPDX1genetic
27708008
NEM1_YEASTNEM1genetic
27708008
SODM_YEASTSOD2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
LPLA_YEASTAIM22genetic
27708008
MDM35_YEASTMDM35genetic
27708008
LIPB_YEASTLIP2genetic
27708008
VID22_YEASTVID22genetic
27708008
TOM7_YEASTTOM7genetic
27708008
ODP2_YEASTLAT1genetic
27708008
CISY1_YEASTCIT1genetic
27708008
LIPA_YEASTLIP5genetic
27708008
UBA3_YEASTUBA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YHM2_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory