| UniProt ID | CISY1_YEAST | |
|---|---|---|
| UniProt AC | P00890 | |
| Protein Name | Citrate synthase, mitochondrial {ECO:0000303|PubMed:6090126} | |
| Gene Name | CIT1 {ECO:0000303|PubMed:6090126} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 479 | |
| Subcellular Localization | Mitochondrion matrix . | |
| Protein Description | Specific citrate synthase with catalytic activity only with acetyl-CoA.. | |
| Protein Sequence | MSAILSTTSKSFLSRGSTRQCQNMQKALFALLNARHYSSASEQTLKERFAEIIPAKAEEIKKFKKEHGKTVIGEVLLEQAYGGMRGIKGLVWEGSVLDPEEGIRFRGRTIPEIQRELPKAEGSTEPLPEALFWLLLTGEIPTDAQVKALSADLAARSEIPEHVIQLLDSLPKDLHPMAQFSIAVTALESESKFAKAYAQGVSKKEYWSYTFEDSLDLLGKLPVIASKIYRNVFKDGKITSTDPNADYGKNLAQLLGYENKDFIDLMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPYLSLAAGLNGLAGPLHGRANQEVLEWLFKLREEVKGDYSKETIEKYLWDTLNAGRVVPGYGHAVLRKTDPRYTAQREFALKHFPDYELFKLVSTIYEVAPGVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEASFYTVLFGVARAIGVLPQLIIDRAVGAPIERPKSFSTEKYKELVKKIESKN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSAILSTTS ------CCCCHHCCC | 24.82 | 19823750 | |
| 6 | Phosphorylation | --MSAILSTTSKSFL --CCCCHHCCCHHHH | 24.43 | 19823750 | |
| 7 | Phosphorylation | -MSAILSTTSKSFLS -CCCCHHCCCHHHHH | 31.48 | 19823750 | |
| 8 | Phosphorylation | MSAILSTTSKSFLSR CCCCHHCCCHHHHHC | 30.68 | 19823750 | |
| 9 | Phosphorylation | SAILSTTSKSFLSRG CCCHHCCCHHHHHCC | 26.79 | 19823750 | |
| 26 | Ubiquitination | RQCQNMQKALFALLN HHHHHHHHHHHHHHH | 35.97 | 17644757 | |
| 37 | Phosphorylation | ALLNARHYSSASEQT HHHHHHCCCCCCHHH | 9.96 | 22369663 | |
| 38 | Phosphorylation | LLNARHYSSASEQTL HHHHHCCCCCCHHHH | 17.19 | 22369663 | |
| 39 | Phosphorylation | LNARHYSSASEQTLK HHHHCCCCCCHHHHH | 28.75 | 22369663 | |
| 41 | Phosphorylation | ARHYSSASEQTLKER HHCCCCCCHHHHHHH | 31.99 | 22369663 | |
| 44 | Phosphorylation | YSSASEQTLKERFAE CCCCCHHHHHHHHHH | 35.43 | 22369663 | |
| 56 | 2-Hydroxyisobutyrylation | FAEIIPAKAEEIKKF HHHHCCCCHHHHHHH | 51.48 | - | |
| 56 | Acetylation | FAEIIPAKAEEIKKF HHHHCCCCHHHHHHH | 51.48 | 24489116 | |
| 61 | Acetylation | PAKAEEIKKFKKEHG CCCHHHHHHHHHHHC | 56.27 | 24489116 | |
| 69 | Acetylation | KFKKEHGKTVIGEVL HHHHHHCCCCHHHHH | 41.34 | 24489116 | |
| 88 | Acetylation | YGGMRGIKGLVWEGS HCCCCCCCEEEEECC | 49.36 | 24489116 | |
| 88 | Succinylation | YGGMRGIKGLVWEGS HCCCCCCCEEEEECC | 49.36 | 23954790 | |
| 95 | Phosphorylation | KGLVWEGSVLDPEEG CEEEEECCCCCHHHC | 14.16 | 30377154 | |
| 172 | Ubiquitination | QLLDSLPKDLHPMAQ HHHHCCCCCCCHHHH | 77.53 | 17644757 | |
| 192 | Ubiquitination | TALESESKFAKAYAQ HHHHCHHHHHHHHHC | 45.34 | 22817900 | |
| 195 | Acetylation | ESESKFAKAYAQGVS HCHHHHHHHHHCCCC | 45.09 | 22865919 | |
| 195 | 2-Hydroxyisobutyrylation | ESESKFAKAYAQGVS HCHHHHHHHHHCCCC | 45.09 | - | |
| 195 | Ubiquitination | ESESKFAKAYAQGVS HCHHHHHHHHHCCCC | 45.09 | 22817900 | |
| 203 | Succinylation | AYAQGVSKKEYWSYT HHHCCCCHHHHHCEE | 47.41 | 23954790 | |
| 204 | 2-Hydroxyisobutyrylation | YAQGVSKKEYWSYTF HHCCCCHHHHHCEEC | 48.83 | - | |
| 227 | Acetylation | KLPVIASKIYRNVFK CHHHHHHHHHHHHHC | 34.43 | 22865919 | |
| 234 | Acetylation | KIYRNVFKDGKITST HHHHHHHCCCCCCCC | 62.38 | 24489116 | |
| 237 | Ubiquitination | RNVFKDGKITSTDPN HHHHCCCCCCCCCCC | 53.60 | 23749301 | |
| 249 | Acetylation | DPNADYGKNLAQLLG CCCCCHHCHHHHHHC | 42.43 | 24489116 | |
| 331 | Acetylation | FKLREEVKGDYSKET HHHHHHHCCCCCHHH | 49.71 | 22865919 | |
| 336 | Acetylation | EVKGDYSKETIEKYL HHCCCCCHHHHHHHH | 53.28 | 22865919 | |
| 341 | Acetylation | YSKETIEKYLWDTLN CCHHHHHHHHHHHCC | 41.62 | 24489116 | |
| 364 | Phosphorylation | GHAVLRKTDPRYTAQ CCCEECCCCCCCHHH | 44.81 | 28889911 | |
| 369 | Phosphorylation | RKTDPRYTAQREFAL CCCCCCCHHHHHHHH | 20.00 | 28889911 | |
| 377 | Acetylation | AQREFALKHFPDYEL HHHHHHHHHCCCHHH | 39.51 | 24489116 | |
| 377 | Ubiquitination | AQREFALKHFPDYEL HHHHHHHHHCCCHHH | 39.51 | 24961812 | |
| 389 | Phosphorylation | YELFKLVSTIYEVAP HHHHHHHHHHHHHCC | 21.37 | 22369663 | |
| 390 | Phosphorylation | ELFKLVSTIYEVAPG HHHHHHHHHHHHCCC | 21.79 | 22369663 | |
| 392 | Phosphorylation | FKLVSTIYEVAPGVL HHHHHHHHHHCCCCC | 12.39 | 22369663 | |
| 400 | Phosphorylation | EVAPGVLTKHGKTKN HHCCCCCCCCCCCCC | 20.70 | 22369663 | |
| 401 | Acetylation | VAPGVLTKHGKTKNP HCCCCCCCCCCCCCC | 46.31 | 24489116 | |
| 461 | Acetylation | GAPIERPKSFSTEKY CCCCCCCCCCCHHHH | 71.06 | 24489116 | |
| 461 | Ubiquitination | GAPIERPKSFSTEKY CCCCCCCCCCCHHHH | 71.06 | 17644757 | |
| 461 | Succinylation | GAPIERPKSFSTEKY CCCCCCCCCCCHHHH | 71.06 | 23954790 | |
| 462 | Phosphorylation | APIERPKSFSTEKYK CCCCCCCCCCHHHHH | 27.41 | 28076776 | |
| 467 | Acetylation | PKSFSTEKYKELVKK CCCCCHHHHHHHHHH | 62.81 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CISY1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CISY1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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