GCSH_YEAST - dbPTM
GCSH_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GCSH_YEAST
UniProt AC P39726
Protein Name Glycine cleavage system H protein, mitochondrial
Gene Name GCV3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 170
Subcellular Localization Mitochondrion .
Protein Description The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)..
Protein Sequence MLRTTRLWTTRMPTVSKLFLRNSSGNALNKNKLPFLYSSQGPQAVRYTSQHEWIAVHQDKTAFVGITKYATDALGDATYVELPEVGTEIAQGESLGSIESVKSASEIYQPADGTVEEINTNLEENPGVVNEDPMGDGWLVKMKLGEGVNVEQVEGLMSLEQYEKTLVHDD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MLRTTRLWTTR
----CCCCCCEECCC		16.5930377154
5Phosphorylation---MLRTTRLWTTRM
---CCCCCCEECCCC		19.8230377154
9PhosphorylationLRTTRLWTTRMPTVS
CCCCCEECCCCCCCH		14.7630377154
24PhosphorylationKLFLRNSSGNALNKN
HHHEECCCCCCCCCC		39.3521440633
32AcetylationGNALNKNKLPFLYSS
CCCCCCCCCCEEECC		60.1824489116
37PhosphorylationKNKLPFLYSSQGPQA
CCCCCEEECCCCCCC		13.4722369663
38PhosphorylationNKLPFLYSSQGPQAV
CCCCEEECCCCCCCE		20.5222369663
39PhosphorylationKLPFLYSSQGPQAVR
CCCEEECCCCCCCEE		26.1222369663
61PhosphorylationIAVHQDKTAFVGITK
EEEECCCCEEEEECH		33.3527017623
67PhosphorylationKTAFVGITKYATDAL
CCEEEEECHHHHHCC		16.4527017623
102N6-lipoyllysineLGSIESVKSASEIYQ
CCCCEECCCHHHEEC		49.97-
102LipoylationLGSIESVKSASEIYQ
CCCCEECCCHHHEEC		49.97-
102LipoylationLGSIESVKSASEIYQ
CCCCEECCCHHHEEC		49.97-
164AcetylationMSLEQYEKTLVHDD-
CCHHHHHHHHCCCC-		42.0724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GCSH_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GCSH_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GCSH_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PYR1_YEASTURA2genetic
21623372
ACH1_YEASTACH1genetic
21623372
TXTP_YEASTCTP1genetic
21623372
THRC_YEASTTHR4genetic
21623372
SUCA_YEASTLSC1genetic
21623372
ALDH5_YEASTALD5genetic
21623372
SUCB_YEASTLSC2genetic
21623372
CISY1_YEASTCIT1genetic
21623372
ELO1_YEASTELO1genetic
21623372
METC_YEASTIRC7genetic
21623372
CEM1_YEASTCEM1genetic
21623372
AMYG_YEASTSGA1genetic
21623372
ERF3_YEASTSUP35genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
LSM2_YEASTLSM2genetic
27708008
IPYR_YEASTIPP1genetic
27708008
DPOD_YEASTPOL3genetic
27708008
NSE4_YEASTNSE4genetic
27708008
PCF11_YEASTPCF11genetic
27708008
SYF1_YEASTSYF1genetic
27708008
KGUA_YEASTGUK1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
YPT1_YEASTYPT1genetic
27708008
HSF_YEASTHSF1genetic
27708008
BRR6_YEASTBRR6genetic
27708008
SWC4_YEASTSWC4genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
MED6_YEASTMED6genetic
27708008
SLN1_YEASTSLN1genetic
27708008
GRP78_YEASTKAR2genetic
27708008
KRE9_YEASTKRE9genetic
27708008
CENPA_YEASTCSE4genetic
27708008
CWC16_YEASTYJU2genetic
27708008
RSC58_YEASTRSC58genetic
27708008
ERG27_YEASTERG27genetic
27708008
CFT2_YEASTCFT2genetic
27708008
SEC22_YEASTSEC22genetic
27708008
BET5_YEASTBET5genetic
27708008
LST8_YEASTLST8genetic
27708008
CH10_YEASTHSP10genetic
27708008
APC5_YEASTAPC5genetic
27708008
CLP1_YEASTCLP1genetic
27708008
MOT1_YEASTMOT1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
ASA1_YEASTASA1genetic
27708008
SRP54_YEASTSRP54genetic
27708008
BUR1_YEASTSGV1genetic
27708008
PGTB2_YEASTBET2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GCSH_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39, AND MASSSPECTROMETRY.

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