| UniProt ID | SRP54_YEAST | |
|---|---|---|
| UniProt AC | P20424 | |
| Protein Name | Signal recognition particle subunit SRP54 | |
| Gene Name | SRP54 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 541 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPAse-activating proteins (GAPs), thereby resolving their association.. | |
| Protein Sequence | MVLADLGKRINSAVNNAISNTQDDFTTSVDVMLKGIVTALLESDVNIALVSKLRNNIRSQLLSENRSEKSTTNAQTKKLIQKTVFDELCKLVTCEGSEEKAFVPKKRKTNIIMFVGLQGSGKTTSCTKLAVYYSKRGFKVGLVCADTFRAGAFDQLKQNAIRARIPFYGSYTETDPAKVAEEGINKFKKEKFDIIIVDTSGRHHQEEELFQEMIEISNVIKPNQTIMVLDASIGQAAEQQSKAFKESSDFGAIILTKMDGHARGGGAISAVAATNTPIIFIGTGEHIHDLEKFSPKSFISKLLGIGDIESLFEQLQTVSNKEDAKATMENIQKGKFTLLDFKKQMQTIMKMGPLSNIAQMIPGMSNMMNQVGEEETSQKMKKMVYVLDSMTKEELESDGRMFIEEPTRMVRVAKGSGTSVFEVEMILMQQQMMARMAQTATQQQPGAPGANARMPGMPNMPGMPNMPGMPNMPGMPKVTPQMMQQAQQKLKQNPGLMQNMMNMFGGGMGGGMGGGMPDMNEMMKMMQDPQMQQMAKQFGMG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | DLGKRINSAVNNAIS HHHHHHHHHHHHHHH | 31.09 | 21440633 | |
| 38 | Phosphorylation | VMLKGIVTALLESDV HHHHHHHHHHHHCCC | 15.07 | 29688323 | |
| 43 | Phosphorylation | IVTALLESDVNIALV HHHHHHHCCCHHHHH | 46.99 | 29688323 | |
| 51 | Phosphorylation | DVNIALVSKLRNNIR CCHHHHHHHHHHHHH | 27.16 | 29688323 | |
| 100 | Ubiquitination | TCEGSEEKAFVPKKR CCCCCHHCCCCCCCC | 42.97 | 23749301 | |
| 127 | Phosphorylation | SGKTTSCTKLAVYYS CCCCCCCHHHEEEEC | 28.94 | 27017623 | |
| 133 | Phosphorylation | CTKLAVYYSKRGFKV CHHHEEEECCCCCEE | 10.91 | 27017623 | |
| 178 | Acetylation | YTETDPAKVAEEGIN CCCCCHHHHHHHHHH | 47.57 | 24489116 | |
| 186 | Acetylation | VAEEGINKFKKEKFD HHHHHHHHHHHHCCE | 57.55 | 22865919 | |
| 199 | Phosphorylation | FDIIIVDTSGRHHQE CEEEEEECCCCCCCH | 23.37 | 28889911 | |
| 292 | Acetylation | EHIHDLEKFSPKSFI CCCCCHHHHCCHHHH | 59.44 | 24489116 | |
| 296 | Acetylation | DLEKFSPKSFISKLL CHHHHCCHHHHHHHH | 57.72 | 24489116 | |
| 335 | Acetylation | MENIQKGKFTLLDFK HHHHHCCCEEEEHHH | 42.06 | 24489116 | |
| 337 | Phosphorylation | NIQKGKFTLLDFKKQ HHHCCCEEEEHHHHH | 29.87 | 27017623 | |
| 342 | Acetylation | KFTLLDFKKQMQTIM CEEEEHHHHHHHHHH | 41.59 | 22865919 | |
| 355 | Phosphorylation | IMKMGPLSNIAQMIP HHHHCCHHHHHHHCH | 29.35 | 19795423 | |
| 365 | Phosphorylation | AQMIPGMSNMMNQVG HHHCHHHHHHHHHHC | 27.73 | 19795423 | |
| 376 | Phosphorylation | NQVGEEETSQKMKKM HHHCCHHHHHHHHHH | 39.47 | 19795423 | |
| 377 | Phosphorylation | QVGEEETSQKMKKMV HHCCHHHHHHHHHHH | 30.96 | 19795423 | |
| 385 | Phosphorylation | QKMKKMVYVLDSMTK HHHHHHHHHHHHCCH | 7.56 | 22369663 | |
| 389 | Phosphorylation | KMVYVLDSMTKEELE HHHHHHHHCCHHHHH | 24.96 | 22369663 | |
| 391 | Phosphorylation | VYVLDSMTKEELESD HHHHHHCCHHHHHHC | 38.98 | 22369663 | |
| 479 | Phosphorylation | MPGMPKVTPQMMQQA CCCCCCCCHHHHHHH | 17.58 | 24909858 | |
| 489 | Ubiquitination | MMQQAQQKLKQNPGL HHHHHHHHHHHCHHH | 45.64 | 23749301 | |
| 536 | Ubiquitination | PQMQQMAKQFGMG-- HHHHHHHHHHCCC-- | 40.60 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SRP54_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SRP54_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRP54_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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