TKT2_YEAST - dbPTM
TKT2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TKT2_YEAST
UniProt AC P33315
Protein Name Transketolase 2
Gene Name TKL2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 681
Subcellular Localization
Protein Description Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate..
Protein Sequence MAQFSDIDKLAVSTLRLLSVDQVESAQSGHPGAPLGLAPVAHVIFKQLRCNPNNEHWINRDRFVLSNGHSCALLYSMLHLLGYDYSIEDLRQFRQVNSRTPGHPEFHSAGVEITSGPLGQGISNAVGMAIAQANFAATYNEDGFPISDSYTFAIVGDGCLQEGVSSETSSLAGHLQLGNLITFYDSNSISIDGKTSYSFDEDVLKRYEAYGWEVMEVDKGDDDMESISSALEKAKLSKDKPTIIKVTTTIGFGSLQQGTAGVHGSALKADDVKQLKKRWGFDPNKSFVVPQEVYDYYKKTVVEPGQKLNEEWDRMFEEYKTKFPEKGKELQRRLNGELPEGWEKHLPKFTPDDDALATRKTSQQVLTNMVQVLPELIGGSADLTPSNLTRWEGAVDFQPPITQLGNYAGRYIRYGVREHGMGAIMNGISAFGANYKPYGGTFLNFVSYAAGAVRLAALSGNPVIWVATHDSIGLGEDGPTHQPIETLAHLRAIPNMHVWRPADGNETSAAYYSAIKSGRTPSVVALSRQNLPQLEHSSFEKALKGGYVIHDVENPDIILVSTGSEVSISIDAAKKLYDTKKIKARVVSLPDFYTFDRQSEEYRFSVLPDGVPIMSFEVLATSSWGKYAHQSFGLDEFGRSGKGPEIYKLFDFTADGVASRAEKTINYYKGKQLLSPMGRAF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
207PhosphorylationDEDVLKRYEAYGWEV
CHHHHHHHHHHCCEE		11.8819779198
210PhosphorylationVLKRYEAYGWEVMEV
HHHHHHHHCCEEEEE		15.7219779198
273AcetylationALKADDVKQLKKRWG
CCCHHHHHHHHHHHC		57.8325381059
286PhosphorylationWGFDPNKSFVVPQEV
HCCCCCCCCCCCHHH		29.88-
438PhosphorylationFGANYKPYGGTFLNF
CCCCCCCCCCCHHHH		24.8422369663
441PhosphorylationNYKPYGGTFLNFVSY
CCCCCCCCHHHHHHH		22.1622369663
447PhosphorylationGTFLNFVSYAAGAVR
CCHHHHHHHHHHHHH		12.6222369663
448PhosphorylationTFLNFVSYAAGAVRL
CHHHHHHHHHHHHHH		8.6522369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TKT2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TKT2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TKT2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TKT1_YEASTTKL1physical
11805826
G6PD_YEASTZWF1genetic
16941010
MTHR1_YEASTMET12genetic
21623372
ADH3_YEASTADH3genetic
21623372
AATC_YEASTAAT2genetic
21623372
POS5_YEASTPOS5genetic
21623372
TPS2_YEASTTPS2genetic
21623372
ERG2_YEASTERG2genetic
21623372
CEM1_YEASTCEM1genetic
21623372
TKT1_YEASTTKL1genetic
21623372
CYS3_YEASTCYS3genetic
21623372
PPT2_YEASTPPT2genetic
21623372
THDH_YEASTILV1genetic
21623372
ACT_YEASTACT1genetic
27708008
ARPC5_YEASTARC15genetic
27708008
CYAA_YEASTCYR1genetic
27708008
SYA_YEASTALA1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
CHO2_YEASTCHO2genetic
27708008
ITPA_YEASTHAM1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RFA1_YEASTRFA1genetic
27708008
LSM2_YEASTLSM2genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
RPB1_YEASTRPO21genetic
27708008
NOP14_YEASTNOP14genetic
27708008
CDC37_YEASTCDC37genetic
27708008
GPI8_YEASTGPI8genetic
27708008
SYF1_YEASTSYF1genetic
27708008
PRP3_YEASTPRP3genetic
27708008
TSC11_YEASTTSC11genetic
27708008
PSB3_YEASTPUP3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
PSB7_YEASTPRE4genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRP18_YEASTPRP18genetic
27708008
DBF2_YEASTDBF2genetic
27708008
BRL1_YEASTBRL1genetic
27708008
ORC6_YEASTORC6genetic
27708008
DNA2_YEASTDNA2genetic
27708008
PAN1_YEASTPAN1genetic
27708008
ESS1_YEASTESS1genetic
27708008
PRS7_YEASTRPT1genetic
27708008
ERG27_YEASTERG27genetic
27708008
IMB1_YEASTKAP95genetic
27708008
NSE5_YEASTNSE5genetic
27708008
POB3_YEASTPOB3genetic
27708008
CAP_YEASTSRV2genetic
27708008
PRP2_YEASTPRP2genetic
27708008
SEC12_YEASTSEC12genetic
27708008
MVD1_YEASTMVD1genetic
27708008
RPA1_YEASTRPA190genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ORC4_YEASTORC4genetic
27708008
MED10_YEASTNUT2genetic
27708008
NHP10_YEASTNHP10genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
IES5_YEASTIES5genetic
27708008
RAD4_YEASTRAD4genetic
27708008
IES1_YEASTIES1genetic
27708008
AAD6_YEASTAAD6genetic
27708008
TYW3_YEASTTYW3genetic
27708008
MON1_YEASTMON1genetic
27708008
YGS6_YEASTYGL176Cgenetic
27708008
VAM7_YEASTVAM7genetic
27708008
MDM34_YEASTMDM34genetic
27708008
ORM1_YEASTORM1genetic
27708008
ASK10_YEASTASK10genetic
27708008
DHOM_YEASTHOM6genetic
27708008
ELM1_YEASTELM1genetic
27708008
TPM1_YEASTTPM1genetic
27708008
ATG3_YEASTATG3genetic
27708008
MDM12_YEASTMDM12genetic
27708008
COQ7_YEASTCAT5genetic
27708008
TKT1_YEASTTKL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TKT2_YEAST

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Related Literatures of Post-Translational Modification

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