ITPA_YEAST - dbPTM
ITPA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITPA_YEAST
UniProt AC P47119
Protein Name Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}
Gene Name HAM1 {ECO:0000255|HAMAP-Rule:MF_03148}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 197
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions..
Protein Sequence MSNNEIVFVTGNANKLKEVQSILTQEVDNNNKTIHLINEALDLEELQDTDLNAIALAKGKQAVAALGKGKPVFVEDTALRFDEFNGLPGAYIKWFLKSMGLEKIVKMLEPFENKNAEAVTTICFADSRGEYHFFQGITRGKIVPSRGPTTFGWDSIFEPFDSHGLTYAEMSKDAKNAISHRGKAFAQFKEYLYQNDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSNNEIVFV
------CCCCEEEEE		48.6521126336
10PhosphorylationNNEIVFVTGNANKLK
CCEEEEEECCHHHHH		17.1628132839
17AcetylationTGNANKLKEVQSILT
ECCHHHHHHHHHHHH		58.4024489116
21PhosphorylationNKLKEVQSILTQEVD
HHHHHHHHHHHHEEC		25.4128152593
24PhosphorylationKEVQSILTQEVDNNN
HHHHHHHHHEECCCC		22.4828132839
60UbiquitinationAIALAKGKQAVAALG
HHHHHHHHHHHHHHC		34.0823749301
602-HydroxyisobutyrylationAIALAKGKQAVAALG
HHHHHHHHHHHHHHC		34.08-
77PhosphorylationKPVFVEDTALRFDEF
CCEEEECCEECCHHH		17.6822369663
93UbiquitinationGLPGAYIKWFLKSMG
CCCHHHHHHHHHHCC		21.1522817900
97UbiquitinationAYIKWFLKSMGLEKI
HHHHHHHHHCCHHHH		28.9922817900
97AcetylationAYIKWFLKSMGLEKI
HHHHHHHHHCCHHHH		28.9924489116
103AcetylationLKSMGLEKIVKMLEP
HHHCCHHHHHHHHHH		58.8224489116
106AcetylationMGLEKIVKMLEPFEN
CCHHHHHHHHHHHCC		41.0422865919
189UbiquitinationGKAFAQFKEYLYQND
HHHHHHHHHHHHHCC		33.1122817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ITPA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITPA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITPA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VATB_YEASTVMA2physical
16554755
SRB8_YEASTSRB8genetic
19325107
LHS1_YEASTLHS1genetic
19325107
CARA_YEASTCPA1genetic
24124444
CARB_YEASTCPA2genetic
24124444
YJF5_YEASTYJL055Wgenetic
24124444
GPR1_YEASTGPR1genetic
27708008
BAP3_YEASTBAP3genetic
27708008
MRM2_YEASTMRM2genetic
27708008
INO4_YEASTINO4genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
REI1_YEASTREI1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
YFF2_YEASTYFL052Wgenetic
27708008
YGZ2_YEASTYGL242Cgenetic
27708008
STF2_YEASTSTF2genetic
27708008
SLH1_YEASTSLH1genetic
27708008
THIK_YEASTPOT1genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
CPYI_YEASTTFS1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
APP1_YEASTAPP1genetic
27708008
KTR1_YEASTKTR1genetic
27708008
FABD_YEASTMCT1genetic
27708008
YDC1_YEASTYDC1genetic
27708008
NEW1_YEASTNEW1genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
UBA3_YEASTUBA3genetic
27708008
SPEE_YEASTSPE3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITPA_YEAST

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Related Literatures of Post-Translational Modification

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