APP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APP1_YEAST
• UniProt AC: P53933
• Protein Name: Phosphatidate phosphatase APP1
• Gene Name: APP1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 587
• Subcellular Localization: Cytoplasm, cytoskeleton, actin patch .
• Protein Description: Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. May play a role in vesicular trafficking through its PAP activity at cortical actin patches..
• Protein Sequence: MNSQGYDESSSSTAATSGPTSGDPRMGKKQRFMNLIRTTKDVYIPNLTSSISQKTMDGIRSTTNSFEGYNDLPMELPHNTTITYFPTYTTTNLVDPDGLSAPRKDFETTVRCAVSYPGNPTSRRNRWLLSLCKQYLRTGTAEADVAPVVPPHLEEDSGDLNDSQSSIESSLSSKSENRYSHMGIQEEDVLNERIQGFLSKKVPNTPVVVDLLPKDKLRGDTASFFGTTDSYGNLLIKAETDFLPSKINITLDTPIEGHADPISETFPANYVSPYGIGLISDIDDTIKHTGVTGDRRSMFRNVFIHDVQSWVIDGVPLWYKTLHDVADVDFFYVSNSPIQTFTLLKQYICANFPPGPIFLKQYSGNFFSTIMTSSANRKIQPIANILKDFPKKKFILVGDSGEHDLEAYTTTALQFPNQILAIYIRCCSNSMSDVPSHDEEVMNEVNNIIELQQRPMQMTKSTVRTRRRPPPPPIPSTQKPSLTEEQTESIRMSRRNKDENNAKRVAPPPLPNRQLPNLDANTYYVPSSQNDYGMYGAFMDKKADEWKRRVMDSIQKLSNQDTTLMFFSDPALSLEDSIRRIREKYSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNSQGYDESSSST --CCCCCCCCCCCCC	14.65	19779198
16	Phosphorylation	SSSSTAATSGPTSGD CCCCCCCCCCCCCCC	31.58	19779198
21	Phosphorylation	AATSGPTSGDPRMGK CCCCCCCCCCCCCCH	44.31	28132839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APP1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OYE2_YEAST	OYE2	physical	11805837
ABP1_YEAST	ABP1	physical	11805837
LSP1_YEAST	LSP1	physical	11805837
CYPH_YEAST	CPR1	physical	11805837
COFI_YEAST	COF1	physical	11805837
MDHM_YEAST	MDH1	physical	11805837
FYV8_YEAST	FYV8	physical	11805837
PGM2_YEAST	PGM2	physical	11805837
SSN8_YEAST	SSN8	physical	10688190
AIM2_YEAST	AIM2	physical	10688190
RV167_YEAST	RVS167	physical	11489916
ABP1_YEAST	ABP1	physical	14737190
ACA2_YEAST	CST6	physical	16554755
AIM2_YEAST	AIM2	physical	18719252
SSN8_YEAST	SSN8	physical	18719252
RV167_YEAST	RVS167	physical	18719252
RGD1_YEAST	RGD1	physical	18719252
WHI2_YEAST	WHI2	physical	18719252
LSB3_YEAST	LSB3	physical	18719252
BZZ1_YEAST	BZZ1	physical	18719252
GEM1_YEAST	GEM1	genetic	20093466
IPT1_YEAST	IPT1	genetic	20093466
EMI1_YEAST	EMI1	genetic	20093466
PCP1_YEAST	PCP1	genetic	20093466
CHO2_YEAST	CHO2	genetic	20093466
PHB2_YEAST	PHB2	genetic	20093466
FEN1_YEAST	RAD27	genetic	20093466
MDM35_YEAST	MDM35	genetic	20093466
IRA2_YEAST	IRA2	genetic	20093466
PET20_YEAST	PET20	genetic	20093466
RRP1_YEAST	RRP1	genetic	27708008
PSB7_YEAST	PRE4	genetic	27708008
TIM44_YEAST	TIM44	genetic	27708008
TIM14_YEAST	PAM18	genetic	27708008
GRPE_YEAST	MGE1	genetic	27708008
GEM1_YEAST	GEM1	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
MDM35_YEAST	MDM35	genetic	27708008
SNX9_HUMAN	SNX9	physical	27107014
PACN2_HUMAN	PACSIN2	physical	27107014
CCDB1_HUMAN	CCNDBP1	physical	27107014
TRI27_HUMAN	TRIM27	physical	27107014
MD1L1_HUMAN	MAD1L1	physical	27107014
GOGA2_HUMAN	GOLGA2	physical	27107014
CIP4_HUMAN	TRIP10	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.