| UniProt ID | TIM44_YEAST | |
|---|---|---|
| UniProt AC | Q01852 | |
| Protein Name | Mitochondrial import inner membrane translocase subunit TIM44 | |
| Gene Name | TIM44 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 431 | |
| Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein . |
|
| Protein Description | Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (MGE1) to drive protein translocation into the matrix using ATP as an energy source.. | |
| Protein Sequence | MHRSTFIRTSGTSSRTLTARYRSQYTGLLVARVLFSTSTTRAQGGNPRSPLQIFRDTFKKEWEKSQELQENIKTLQDASGKLGESEAYKKAREAYLKAQRGSTIVGKTLKKTGETMEHIATKAWESELGKNTRKAAAATAKKLDESFEPVRQTKIYKEVSEVIDDGESSRYGGFITKEQRRLKRERDLASGKRHRAVKSNEDAGTAVVATNIESKESFGKKVEDFKEKTVVGRSIQSLKNKLWDESENPLIVVMRKITNKVGGFFAETESSRVYSQFKLMDPTFSNESFTRHLREYIVPEILEAYVKGDVKVLKKWFSEAPFNVYAAQQKIFKEQDVYADGRILDIRGVEIVSAKLLAPQDIPVLVVGCRAQEINLYRKKKTGEIAAGDEANILMSSYAMVFTRDPEQIDDDETEGWKILEFVRGGSRQFT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Phosphorylation | AQGGNPRSPLQIFRD CCCCCCCCHHHHHHH | 31.08 | 27017623 | |
| 64 | Acetylation | TFKKEWEKSQELQEN HHHHHHHHHHHHHHH | 59.52 | 24489116 | |
| 81 | Acetylation | TLQDASGKLGESEAY HHHHHCCCCCCHHHH | 51.31 | 24489116 | |
| 157 | Acetylation | VRQTKIYKEVSEVID HHHCHHHHHHHHCCC | 55.93 | 24489116 | |
| 160 | Phosphorylation | TKIYKEVSEVIDDGE CHHHHHHHHCCCCCC | 27.51 | 30377154 | |
| 168 | Phosphorylation | EVIDDGESSRYGGFI HCCCCCCCCCCCCCC | 26.16 | 28889911 | |
| 169 | Phosphorylation | VIDDGESSRYGGFIT CCCCCCCCCCCCCCC | 25.81 | 28889911 | |
| 171 | Phosphorylation | DDGESSRYGGFITKE CCCCCCCCCCCCCHH | 24.45 | 21440633 | |
| 177 | Acetylation | RYGGFITKEQRRLKR CCCCCCCHHHHHHHH | 47.21 | 24489116 | |
| 192 | Acetylation | ERDLASGKRHRAVKS HHHHHCCCHHHCHHC | 42.40 | 25381059 | |
| 214 | Phosphorylation | VVATNIESKESFGKK EEEEECCCHHHHCCC | 37.62 | 28889911 | |
| 241 | Acetylation | SIQSLKNKLWDESEN HHHHHHHHCCCCCCC | 49.74 | 24489116 | |
| 278 | Acetylation | SRVYSQFKLMDPTFS HHHCEEEEECCCCCC | 34.95 | 24489116 | |
| 307 | Acetylation | EILEAYVKGDVKVLK HHHHHHHHCCHHHHH | 36.40 | 24489116 | |
| 311 | Acetylation | AYVKGDVKVLKKWFS HHHHCCHHHHHHHHH | 46.73 | 24489116 | |
| 333 | Acetylation | AAQQKIFKEQDVYAD HHHHHHHHHCCCCCC | 58.92 | 24489116 | |
| 333 | Succinylation | AAQQKIFKEQDVYAD HHHHHHHHHCCCCCC | 58.92 | 23954790 | |
| 355 | Acetylation | GVEIVSAKLLAPQDI CEEEEEEEECCCCCC | 36.21 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TIM44_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TIM44_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TIM44_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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