| UniProt ID | TIM50_YEAST | |
|---|---|---|
| UniProt AC | Q02776 | |
| Protein Name | Mitochondrial import inner membrane translocase subunit TIM50 | |
| Gene Name | TIM50 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 476 | |
| Subcellular Localization |
Mitochondrion inner membrane Single-pass membrane protein . |
|
| Protein Description | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex. Does not act as a structural subunit of the TIM23 complex but plays a dynamic role in protein import. Has no phosphatase activity.. | |
| Protein Sequence | MLSILRNSVRLNSRALRVVPSAANTLTSVQASRRLLTSYSSFLQKETKDDKPKSILTDDMLFKAGVDVDEKGQGKNEETSGEGGEDKNEPSSKSEKSRRKRQTSTDIKREKYANWFYIFSLSALTGTAIYMARDWEPQESEELKKDIDNGYTLSLMYKRFKARFNSMFTYFQEPPFPDLLPPPPPPPYQRPLTLVITLEDFLVHSEWSQKHGWRTAKRPGADYFLGYLSQYYEIVLFSSNYMMYSDKIAEKLDPIHAFVSYNLFKEHCVYKDGVHIKDLSKLNRDLSKVIIIDTDPNSYKLQPENAIPMEPWNGEADDKLVRLIPFLEYLATQQTKDVRPILNSFEDKKNLAEEFDHRVKKLKDKFYGDHKSGGNWAMTALGLGNSLGGSTKFPLDLIHEEGQKNYLMFMKMIEEEKEKIRIQQEQMGGQTFTLKDYVEGNLPSPEEQMKIQLEKQKEVDALFEEEKKKKKIAESK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 51 | Acetylation | QKETKDDKPKSILTD HHHCCCCCCCCCCCH | 65.56 | 24489116 | |
| 80 | Phosphorylation | QGKNEETSGEGGEDK CCCCCCCCCCCCCCC | 37.82 | 28889911 | |
| 104 | Phosphorylation | SRRKRQTSTDIKREK HHHHCCCCHHHHHHH | 18.75 | 28889911 | |
| 112 | Phosphorylation | TDIKREKYANWFYIF HHHHHHHHHCEEEEE | 10.62 | 30377154 | |
| 117 | Phosphorylation | EKYANWFYIFSLSAL HHHHCEEEEEEHHHH | 7.83 | 30377154 | |
| 120 | Phosphorylation | ANWFYIFSLSALTGT HCEEEEEEHHHHHCC | 16.32 | 30377154 | |
| 151 | Phosphorylation | KKDIDNGYTLSLMYK HHHCCCCHHHHHHHH | 15.68 | 19823750 | |
| 152 | Phosphorylation | KDIDNGYTLSLMYKR HHCCCCHHHHHHHHH | 15.98 | 19823750 | |
| 154 | Phosphorylation | IDNGYTLSLMYKRFK CCCCHHHHHHHHHHH | 11.86 | 19823750 | |
| 157 | Phosphorylation | GYTLSLMYKRFKARF CHHHHHHHHHHHHHH | 12.33 | 19823750 | |
| 223 | Phosphorylation | AKRPGADYFLGYLSQ CCCCCCHHHHHHHHH | 10.52 | 30377154 | |
| 227 | Phosphorylation | GADYFLGYLSQYYEI CCHHHHHHHHHHEEE | 12.82 | 30377154 | |
| 229 | Phosphorylation | DYFLGYLSQYYEIVL HHHHHHHHHHEEEEE | 13.98 | 30377154 | |
| 231 | Phosphorylation | FLGYLSQYYEIVLFS HHHHHHHHEEEEEEC | 10.33 | 30377154 | |
| 232 | Phosphorylation | LGYLSQYYEIVLFSS HHHHHHHEEEEEECC | 7.49 | 30377154 | |
| 238 | Phosphorylation | YYEIVLFSSNYMMYS HEEEEEECCCCCCCC | 17.32 | 30377154 | |
| 239 | Phosphorylation | YEIVLFSSNYMMYSD EEEEEECCCCCCCCH | 25.33 | 30377154 | |
| 241 | Phosphorylation | IVLFSSNYMMYSDKI EEEECCCCCCCCHHH | 5.80 | 30377154 | |
| 244 | Phosphorylation | FSSNYMMYSDKIAEK ECCCCCCCCHHHHHH | 9.37 | 30377154 | |
| 245 | Phosphorylation | SSNYMMYSDKIAEKL CCCCCCCCHHHHHHC | 17.96 | 30377154 | |
| 251 | Acetylation | YSDKIAEKLDPIHAF CCHHHHHHCCCCHHH | 49.52 | 24489116 | |
| 277 | Acetylation | YKDGVHIKDLSKLNR EECCCCHHHHHHCCC | 37.43 | 22865919 | |
| 450 | Acetylation | PSPEEQMKIQLEKQK CCHHHHHHHHHHHHH | 27.31 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TIM50_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TIM50_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TIM50_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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