TIM17_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIM17_YEAST
• UniProt AC: P39515
• Protein Name: Mitochondrial import inner membrane translocase subunit TIM17
• Gene Name: TIM17
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 158
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein.
• Protein Description: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane..
• Protein Sequence: MSADHSRDPCPIVILNDFGGAFAMGAIGGVVWHGIKGFRNSPLGERGSGAMSAIKARAPVLGGNFGVWGGLFSTFDCAVKAVRKREDPWNAIIAGFFTGGALAVRGGWRHTRNSSITCACLLGVIEGVGLMFQRYAAWQAKPMAPPLPEAPSSQPLQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Ubiquitination	STFDCAVKAVRKRED HHHHHHHHHHHCCCC	23.73	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIM17_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIM17_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIM17_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP77_YEAST	SSC1	physical	9171336
TIM14_YEAST	PAM18	physical	14517234
TIM23_YEAST	TIM23	physical	14517234
TIM44_YEAST	TIM44	physical	14517234
TIM50_YEAST	TIM50	physical	14517234
TIM16_YEAST	PAM16	physical	14981506
TIM23_YEAST	TIM23	physical	9412462
HSP77_YEAST	SSC1	physical	10393182
TIM23_YEAST	TIM23	physical	9374535
HSP77_YEAST	SSC1	genetic	9171336
TIM14_YEAST	PAM18	genetic	15797382
TIM23_YEAST	TIM23	genetic	7556166
TIM21_YEAST	TIM21	physical	15878866
TIM50_YEAST	TIM50	physical	15878866
TIM44_YEAST	TIM44	physical	15878866
TIM23_YEAST	TIM23	physical	15878866
TIM17_YEAST	TIM17	physical	15878866
TIM16_YEAST	PAM16	physical	15878866
TIM14_YEAST	PAM18	physical	15878866
TIM44_YEAST	TIM44	physical	17452317
TIM23_YEAST	TIM23	physical	17452317
TIM16_YEAST	PAM16	physical	17452317
TIM14_YEAST	PAM18	physical	17452317
TIM50_YEAST	TIM50	physical	18418384
TIM23_YEAST	TIM23	physical	18418384
TIM44_YEAST	TIM44	physical	18418384
TIM14_YEAST	PAM18	physical	18418384
TIM16_YEAST	PAM16	physical	18418384
TIM21_YEAST	TIM21	physical	18418384
PAM17_YEAST	PAM17	physical	18418384
TIM23_YEAST	TIM23	physical	17959826
TIM50_YEAST	TIM50	physical	26714107
TIM44_YEAST	TIM44	physical	26714107
TIM14_YEAST	PAM18	physical	26714107
TIM16_YEAST	PAM16	physical	26714107
TIM23_YEAST	TIM23	physical	26714107
TIM23_YEAST	TIM23	genetic	27708008
TIM50_YEAST	TIM50	genetic	27708008
YD157_YEAST	YDL157C	genetic	27708008
PAM17_YEAST	PAM17	genetic	27708008
XDJ1_YEAST	XDJ1	genetic	27708008
UPS1_YEAST	UPS1	genetic	27708008
TIM50_YEAST	TIM50	physical	28165323
TIM44_YEAST	TIM44	physical	28165323
TIM23_YEAST	TIM23	physical	28165323
TIM14_YEAST	PAM18	physical	28165323
TIM16_YEAST	PAM16	physical	28165323
TIM23_YEAST	TIM23	physical	27402832
PAM17_YEAST	PAM17	physical	25157107

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.