ALDH2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALDH2_RAT
• UniProt AC: P11884
• Protein Name: Aldehyde dehydrogenase, mitochondrial
• Gene Name: Aldh2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 519
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MLRAALSTARRGPRLSRLLSAAATSAVPAPNQQPEVFCNQIFINNEWHDAVSKKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAAQAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Acetylation	EWHDAVSKKTFPTVN CCHHHHCCCCCCCCC	49.59	22902405
54	Succinylation	WHDAVSKKTFPTVNP CHHHHCCCCCCCCCC	48.14	26843850
54	Acetylation	WHDAVSKKTFPTVNP CHHHHCCCCCCCCCC	48.14	26302492
75	Acetylation	CQVAEGNKEDVDKAV EEEECCCHHHHHHHH	67.17	22902405
80	Acetylation	GNKEDVDKAVKAAQA CCHHHHHHHHHHHHH	55.73	26302492
83	Acetylation	EDVDKAVKAAQAAFQ HHHHHHHHHHHHHHH	42.75	26302492
93	Phosphorylation	QAAFQLGSPWRRMDA HHHHHCCCCCCCCCH	29.86	30181290
137	Phosphorylation	GKPYVISYLVDLDMV CCCEEEEEEEHHHHH	10.30	31136979
157	Acetylation	YYAGWADKYHGKTIP HHHCCHHHHCCEEEE	31.25	22902405
158	Phosphorylation	YAGWADKYHGKTIPI HHCCHHHHCCEEEEC	19.15	23991683
161	Acetylation	WADKYHGKTIPIDGD CHHHHCCEEEECCCC	29.93	22902405
171	Phosphorylation	PIDGDFFSYTRHEPV ECCCCCCCEECCCCC	26.11	30181290
172	Phosphorylation	IDGDFFSYTRHEPVG CCCCCCCEECCCCCC	11.57	30181290
173	Phosphorylation	DGDFFSYTRHEPVGV CCCCCCEECCCCCCC	25.09	30181290
279	Phosphorylation	IQVAAGSSNLKRVTL HHHHCCCCCCCEEEE	45.31	28689409
285	Phosphorylation	SSNLKRVTLELGGKS CCCCCEEEEECCCCC	20.67	23984901
356	Phosphorylation	VVGNPFDSRTEQGPQ CCCCCCCCCCCCCCC	41.29	21738781
358	Phosphorylation	GNPFDSRTEQGPQVD CCCCCCCCCCCCCCC	36.29	21738781
367	Phosphorylation	QGPQVDETQFKKILG CCCCCCHHHHHHHHH	34.54	28689409
370	Acetylation	QVDETQFKKILGYIK CCCHHHHHHHHHHHH	29.14	22902405
377	Acetylation	KKILGYIKSGQQEGA HHHHHHHHCCCCCCC	39.80	22902405
385	Acetylation	SGQQEGAKLLCGGGA CCCCCCCEEEECCCC	53.50	-
409	Acetylation	PTVFGDVKDGMTIAK CCCEECCCCCCEEEH	53.99	22902405
416	Acetylation	KDGMTIAKEEIFGPV CCCCEEEHHHHHHHH	52.62	22902405
428	Acetylation	GPVMQILKFKTIEEV HHHHHHHEECCHHHH	46.58	22902405
430	Acetylation	VMQILKFKTIEEVVG HHHHHEECCHHHHHC	47.18	22902405
443	Acetylation	VGRANNSKYGLAAAV HCCCCCCCCCEEEEE	45.52	22902405
453	Acetylation	LAAAVFTKDLDKANY EEEEEEECCHHHHHH	44.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALDH2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALDH2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALDH2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.