dbPTM

TIP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TIP1_YEAST
UniProt AC	P27654
Protein Name	Temperature shock-inducible protein 1
Gene Name	TIP1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	210
Subcellular Localization	Secreted, cell wall. Membrane Lipid-anchor, GPI-anchor. Covalently-linked GPI-modified cell wall protein (GPI-CWP) found only in mother cells.
Protein Description	Seems to have esterase activity. Prefers ester of fatty acids from 4 to 16 carbon atoms..
Protein Sequence	MSVSKIAFVLSAIASLAVADTSAAETAELQAIIGDINSHLSDYLGLETGNSGFQIPSDVLSVYQQVMTYTDDAYTTLFSELDFDAITKTIVKLPWYTTRLSSEIAAALASVSPASSEAASSSEAASSSKAASSSEATSSAAPSSSAAPSSSAAPSSSAESSSKAVSSSVAPTTSSVSTSTVETASNAGQRVNAGAASFGAVVAGAAALLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
179	Phosphorylation	TTSSVSTSTVETASN CCCCCCCCCCCCCCH	23.97	21440633
186	GPI-anchor	STVETASNAGQRVNA CCCCCCCHHCCCCCC	45.70	10216230

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TIP1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TIP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TIP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP3_YEAST	UBP3	physical	16554755
EMC5_YEAST	EMC5	genetic	16269340
TLG2_YEAST	TLG2	genetic	16269340
PGA3_YEAST	PGA3	genetic	16269340
RGP1_YEAST	RGP1	genetic	16269340
PLMT_YEAST	OPI3	genetic	16269340
GAS1_YEAST	GAS1	genetic	16269340
PGA14_YEAST	YNL190W	genetic	23891562
BCK1_YEAST	BCK1	genetic	23891562
TCPD_YEAST	CCT4	genetic	27708008
SEC1_YEAST	SEC1	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
RRN7_YEAST	RRN7	genetic	27708008
FIP1_YEAST	FIP1	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
SMP3_YEAST	SMP3	genetic	27708008
UBQL1_HUMAN	UBQLN1	physical	27107014

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TIP1_YEAST

Related Literatures of Post-Translational Modification

GPI-anchor
Reference	PubMed
"Comprehensive proteomic analysis of Saccharomyces cerevisiae cellwalls: identification of proteins covalently attached viaglycosylphosphatidylinositol remnants or mild alkali-sensitivelinkages."; Yin Q.Y., de Groot P.W.J., Dekker H.L., de Jong L., Klis F.M.,de Koster C.G.; J. Biol. Chem. 280:20894-20901(2005). Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, ANDPROBABLE GPI-ANCHOR.	15781460 [Abstract]
"Structure of the glucan-binding sugar chain of Tip1p, a cell wallprotein of Saccharomyces cerevisiae."; Fujii T., Shimoi H., Iimura Y.; Biochim. Biophys. Acta 1427:133-144(1999). Cited for: PROTEIN SEQUENCE OF 20-48 AND 90-100, PROTEIN SEQUENCE OF 130-148 AND164-186, AND GPI-ANCHOR AT ASN-186.	10216230 [Abstract]