SLH1_YEAST - dbPTM
SLH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLH1_YEAST
UniProt AC P53327
Protein Name Antiviral helicase SLH1
Gene Name SLH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1967
Subcellular Localization Cytoplasm .
Protein Description Together with SKI2, represses the translation of non-poly(A) mRNAs. May block translation by inhibiting translation initiation factor 5B (FUN12) action on mRNAs lacking a 3' poly(A) structure. Involved in antiviral defense, preventing L-A dsRNA virus propagation by specifically blocking translation of viral mRNAs..
Protein Sequence MSTEYSADSSKSFMIAMQSMIDTSQTFNLDRSKISLPDFDDELKKVQKDEQNQRTELTVLSQDRNDWDDIFEEFKDISFAQLQSIIDSYKTKNAVAVYKKIGKLINEAETTLSSNVLLETVLQMVYKHQKQELEKELLDFLGTGNIDLVSLLLQHRRMIVATPIETTILLIKNAVNSTPEFLTQQDIRNQVLKSAEDAKNRKLNPATKIIKYPHVFRKYEAGSTTAMAFAGQKFTLPVGTTRMSYNTHEEIIIPAADQASNKNYLYTKLLKISDLDHFCKTVFPYETLNQIQSLVYPVAYKTNENMLICAPTGAGKTDIALLTIINTIKQFSVVNGENEIDIQYDDFKVIYVAPLKALAAEIVDKFSKKLAPFNIQVRELTGDMQLTKAEILATQVIVTTPEKWDVVTRKANGDNDLVSKVKLLIIDEVHLLHEDRGSVIETLVARTLRQVESSQSMIRIIGLSATLPNFMDVADFLGVNRQIGMFYFDQSFRPKPLEQQLLGCRGKAGSRQSKENIDKVAYDKLSEMIQRGYQVMVFVHSRKETVKSARNFIKLAESNHEVDLFAPDPIEKDKYSRSLVKNRDKDMKEIFQFGFGIHHAGMARSDRNLTEKMFKDGAIKVLCCTATLAWGVNLPADCVIIKGTQVYDSKKGGFIDLGISDVIQIFGRGGRPGFGSANGTGILCTSNDRLDHYVSLITQQHPIESRFGSKLVDNLNAEISLGSVTNVDEAIEWLGYTYMFVRMRKNPFTYGIDWEEIANDPQLYERRRKMIVVAARRLHALQMIVFDEVSMHFIAKDLGRVSSDFYLLNESVEIFNQMCDPRATEADVLSMISMSSEFDGIKFREEESKELKRLSDESVECQIGSQLDTPQGKANVLLQAYISQTRIFDSALSSDSNYVAQNSVRICRALFLIGVNRRWGKFSNVMLNICKSIEKRLWAFDHPLCQFDLPENIIRRIRDTKPSMEHLLELEADELGELVHNKKAGSRLYKILSRFPKINIEAEIFPITTNVMRIHIALGPDFVWDSRIHGDAQFFWVFVEESDKSQILHFEKFILNRRQLNNQHEMDFMIPLSDPLPPQVVVKVVSDTWIGCESTHAISFQHLIRPFNETLQTKLLKLRPLPTSALQNPLIESIYPFKYFNPMQTMTFYTLYNTNENAFVGSPTGSGKTIVAELAIWHAFKTFPGKKIVYIAPMKALVRERVDDWRKKITPVTGDKVVELTGDSLPDPKDVHDATIVITTPEKFDGISRNWQTRKFVQDVSLIIMDEIHLLASDRGPILEMIVSRMNYISSQTKQPVRLLGMSTAVSNAYDMAGWLGVKDHGLYNFPSSVRPVPLKMYIDGFPDNLAFCPLMKTMNKPVFMAIKQHSPDKPALIFVASRRQTRLTALDLIHLCGMEDNPRRFLNIDDEEELQYYLSQVTDDTLKLSLQFGIGLHHAGLVQKDRSISHQLFQKNKIQILIATSTLAWGVNLPAHLVIIKGTQFFDAKIEGYRDMDLTDILQMMGRAGRPAYDTTGTAIVYTKESKKMFYKHFLNVGFPVESSLHKVLDDHLGAEITSGSITNKQEALDFLSWTFLFRRAHHNPTYYGIEDDTSTAGVSEHLSSLIDSTLENLRESQCVLLHGDDIVATPFLSISSYYYISHLTIRQLLKQIHDHATFQEVLRWLSLAVEYNELPVRGGEIIMNEEMSQQSRYSVESTFTDEFELPMWDPHVKTFLLLQAHLSRVDLPIADYIQDTVSVLDQSLRILQAYIDVASELGYFHTVLTMIKMMQCIKQGYWYEDDPVSVLPGLQLRRIKDYTFSEQGFIEMTPQQKKKKLLTLEEIGRFGYKKLLNVFDQLTFGMTESEDTKKRFVSVCQRLPVLEGMKFEEQENNEVLTFYSKHLSSKHNNGFEVYCDKFPKIQKELWFLIGHKGDELLMIKRCQPKQMNKEVIIHCDLFIPEEIRGEELQFSLINDALGLRYDMVHKLIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
44AcetylationPDFDDELKKVQKDEQ
CCCCHHHHHHHHHHC		49.1824489116
178PhosphorylationIKNAVNSTPEFLTQQ
HHHHHCCCHHHHCHH		22.9527214570
211AcetylationNPATKIIKYPHVFRK
CCCHHHHCCCCCCCC		57.0924489116
271UbiquitinationYLYTKLLKISDLDHF
CEEEEEHHHHHHHHH		51.0724961812
317PhosphorylationAPTGAGKTDIALLTI
CCCCCCHHHHHHHHH		31.5521126336
365AcetylationLAAEIVDKFSKKLAP
HHHHHHHHHHHHHCC		40.4124489116
387PhosphorylationLTGDMQLTKAEILAT
CCCCCCCCHHHHEEE		16.0027017623
408PhosphorylationPEKWDVVTRKANGDN
HHHCEEEEEECCCCC		26.7119795423
419PhosphorylationNGDNDLVSKVKLLII
CCCCCHHHHEEEEEE		38.7419795423
1123PhosphorylationLKLRPLPTSALQNPL
HHCCCCCCHHHCCCC		34.0219823750
1124PhosphorylationKLRPLPTSALQNPLI
HCCCCCCHHHCCCCC		25.6619823750
1133PhosphorylationLQNPLIESIYPFKYF
HCCCCCCHHCCCCCC		22.0419823750
1135PhosphorylationNPLIESIYPFKYFNP
CCCCCHHCCCCCCCC		16.3419823750
1207UbiquitinationERVDDWRKKITPVTG
HHHHHHHHHCCCCCC		44.2519722269
1208UbiquitinationRVDDWRKKITPVTGD
HHHHHHHHCCCCCCC		43.1519722269
1284PhosphorylationPILEMIVSRMNYISS
HHHHHHHHHHHHHHC		18.1928889911
1288PhosphorylationMIVSRMNYISSQTKQ
HHHHHHHHHHCCCCC		7.8828889911
1293PhosphorylationMNYISSQTKQPVRLL
HHHHHCCCCCCCHHC		33.3328889911
1540PhosphorylationNVGFPVESSLHKVLD
CCCCCCCHHHHHHHH		38.1328889911
1541PhosphorylationVGFPVESSLHKVLDD
CCCCCCHHHHHHHHH		22.4628889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YK03_YEASTYKR023Wphysical
18467557
RIC1_YEASTRIC1genetic
19061648
SWD3_YEASTSWD3genetic
19061648
RPC9_YEASTRPC17genetic
19061648
MOG1_YEASTMOG1genetic
19061648
PAP2_YEASTPAP2genetic
19061648
SAP30_YEASTSAP30genetic
19061648
SYKM_YEASTMSK1genetic
19061648
SKI3_YEASTSKI3genetic
19061648
NOT4_YEASTMOT2genetic
19061648
RXT2_YEASTRXT2genetic
19061648
LSM1_YEASTLSM1genetic
19061648
MLP1_YEASTMLP1genetic
19061648
SWD3_YEASTSWD3genetic
19547744
SKI3_YEASTSKI3genetic
19547744
YK03_YEASTYKR023Wphysical
22615397
PRP11_YEASTPRP11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
CDC53_YEASTCDC53genetic
27708008
CDC37_YEASTCDC37genetic
27708008
CDC4_YEASTCDC4genetic
27708008
ACT_YEASTACT1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
SPC97_YEASTSPC97genetic
27708008
GRC3_YEASTGRC3genetic
27708008
TAD3_YEASTTAD3genetic
27708008
ERB1_YEASTERB1genetic
27708008
RPC6_YEASTRPC34genetic
27708008
HRP1_YEASTHRP1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
PROF_YEASTPFY1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
HPC2_YEASTHPC2genetic
27708008
RL27B_YEASTRPL27Bgenetic
27708008
MEI4_YEASTMEI4genetic
27708008
ALDH5_YEASTALD5genetic
27708008
ODPA_YEASTPDA1genetic
27708008
FTHC_YEASTFAU1genetic
27708008
SKI8_YEASTSKI8genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
FYV8_YEASTFYV8genetic
27708008
ELP2_YEASTELP2genetic
27708008
MED20_YEASTSRB2genetic
27708008
TDA11_YEASTTDA11genetic
27708008
AYT1_YEASTAYT1genetic
27708008
SIC1_YEASTSIC1genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
EFM7_YEASTNNT1genetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
RS29A_YEASTRPS29Agenetic
27708008
SKI2_YEASTSKI2genetic
27708008
PGM3_YEASTPRM15genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
FYV12_YEASTFYV12genetic
27708008
RAD1_YEASTRAD1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
GRE1_YEASTGRE1genetic
27708008
THI21_YEASTTHI21genetic
27708008
CTF4_YEASTCTF4genetic
27708008
SKI3_YEASTSKI3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLH1_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory