dbPTM

AYT1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AYT1_YEAST
UniProt AC	Q12226
Protein Name	Trichothecene 3-O-acetyltransferase
Gene Name	AYT1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	474
Subcellular Localization
Protein Description	Trichothecene 3-O-acetyltransferase involved in self-protection against trichothecenes, mycotoxins acting as eukaryotic protein synthesis inhibitors. Its existence is surprising in a non-trichothecene producer organism which needs no self-protection again endogenic trichothecenes. The persistence of this non-essential gene may be due to a selective advantage that it may confer, like a resistance to exogenic trichothecenes..
Protein Sequence	MFRVKIISQKRTKSVQMLENDQLDILGQQPSLYKLYTQICSIYRVPDPSAHDHIVNTLTRGLETLAKNFQWLAGNVVNEGADEGNTGTYRIVPSDKIPLIVQDLREDLSAPTMDSLEKADFPIYMLDEKTFAPCMTINPPGNTIGMAAKSGPVFAVQANFISGGLVLTIVGQHNIMDITGQESIINLLNKSCHQKPFSDEELLIGNIDKSKSIPLFDETWEPDTTLVHEIVETSRNTSGEEKEQSCSSNSTWAYVEFSAISLQNLRILAMQTCTSGTKFVSTDDIVTAFIWKSVSRARLSRLKPETKSNLGRAVDVRKRLGLPETYPGLLVNMTFNTGSLKSLDHKSLGVLASQIRRKLDPKVFDLAYNTCALATLLSRCPDKTKVSIPQPIDTLSGIMVSSWAKVSLYDVDFNLGLGKPKSVRRPRFISLESLIYFMPRSSRGEMVVALCLRDKDWECLNADKEWTNYATHIG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of AYT1_YEAST !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AYT1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AYT1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AYT1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERG5_YEAST	ERG5	physical	18467557
MOB2_YEAST	MOB2	genetic	27708008
STU1_YEAST	STU1	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
DPOD2_YEAST	POL31	genetic	27708008
MED4_YEAST	MED4	genetic	27708008
DYR_YEAST	DFR1	genetic	27708008
RPA1_YEAST	RPA190	genetic	27708008
PSA7_YEAST	PRE10	genetic	27708008
CET1_YEAST	CET1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AYT1_YEAST

Related Literatures of Post-Translational Modification