TDA11_YEAST - dbPTM
TDA11_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TDA11_YEAST
UniProt AC P38854
Protein Name Topoisomerase I damage affected protein 11
Gene Name TDA11
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 504
Subcellular Localization Cytoplasm .
Protein Description
Protein Sequence MNKFDEFIESNEKDLDVDTSTRNSIISMSPVRKTGRKIRSASSNGYRLEHHRTSSAGSMHSQRLMTPTRLNDQDHPLQAKPDARRVVTRHSSVSVPNAMSKRRSLIQPMVVPTTPESQNNLPSVSHSEGSYGIPLESTTVLSSEQAMASGLRRSRNGSSQSVNSMIATTIPTNGVDVSALLQSLATKELELLECKQKIEDLKKQTQHEEQNYTRRARELHELKEQVSKHLDPSLNTPVKNRAFSPVYQNIPLESRTENAGNSSLPSSVSKPKNMGHQSTNQSRSVSPQDIQERRQRDDSSDSSKQSLWSKPLALFNQFDKIIQHEIERTLNWDDSLSGTPEVQEGTPTSNSESSAQQYDNEAPGARQKSPSQGSVSRSLWSFVSDVKAGLLGIEEENDNDVITDNRCDPVYKSDRQHEQKKSTHKITNRGQAEDSGDDSSLNMRKFKTTTKFQKDNAGNNSLTDESGHRTREKKSKRSSNKLSFIGEPDNDNSSVKNSVEMTDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationEKDLDVDTSTRNSII
CCCCCCCCCCCCCEE		31.6722369663
20PhosphorylationKDLDVDTSTRNSIIS
CCCCCCCCCCCCEEE		22.3922369663
21PhosphorylationDLDVDTSTRNSIISM
CCCCCCCCCCCEEEC		35.6422369663
24PhosphorylationVDTSTRNSIISMSPV
CCCCCCCCEEECCCC		20.2922369663
27PhosphorylationSTRNSIISMSPVRKT
CCCCCEEECCCCCCC		16.1322369663
29PhosphorylationRNSIISMSPVRKTGR
CCCEEECCCCCCCCC		17.2922369663
53PhosphorylationYRLEHHRTSSAGSMH
CCCEEECCCCCCCCC		23.7630377154
54PhosphorylationRLEHHRTSSAGSMHS
CCEEECCCCCCCCCH		20.3928889911
55PhosphorylationLEHHRTSSAGSMHSQ
CEEECCCCCCCCCHH		35.7223749301
61PhosphorylationSSAGSMHSQRLMTPT
CCCCCCCHHCCCCCC		14.3530377154
66PhosphorylationMHSQRLMTPTRLNDQ
CCHHCCCCCCCCCCC		26.5421440633
88PhosphorylationPDARRVVTRHSSVSV
CCHHHHHHCCCCCCC		21.5828889911
91PhosphorylationRRVVTRHSSVSVPNA
HHHHHCCCCCCCCCH		29.1922369663
92PhosphorylationRVVTRHSSVSVPNAM
HHHHCCCCCCCCCHH		16.5822369663
94PhosphorylationVTRHSSVSVPNAMSK
HHCCCCCCCCCHHHH		33.5322369663
233PhosphorylationVSKHLDPSLNTPVKN
HHHHCCHHCCCCCCC		33.6422369663
236PhosphorylationHLDPSLNTPVKNRAF
HCCHHCCCCCCCCCC		34.4522369663
244PhosphorylationPVKNRAFSPVYQNIP
CCCCCCCCCCCCCCC		16.6922369663
247PhosphorylationNRAFSPVYQNIPLES
CCCCCCCCCCCCCHH		10.1421440633
254PhosphorylationYQNIPLESRTENAGN
CCCCCCHHCCCCCCC		52.7824961812
256PhosphorylationNIPLESRTENAGNSS
CCCCHHCCCCCCCCC		42.7621440633
262PhosphorylationRTENAGNSSLPSSVS
CCCCCCCCCCCCCCC		32.1322369663
263PhosphorylationTENAGNSSLPSSVSK
CCCCCCCCCCCCCCC		48.5822369663
266PhosphorylationAGNSSLPSSVSKPKN
CCCCCCCCCCCCCCC		48.9822369663
267PhosphorylationGNSSLPSSVSKPKNM
CCCCCCCCCCCCCCC		28.5922369663
269PhosphorylationSSLPSSVSKPKNMGH
CCCCCCCCCCCCCCC		45.2322369663
278PhosphorylationPKNMGHQSTNQSRSV
CCCCCCCCCCCCCCC		24.5328889911
279PhosphorylationKNMGHQSTNQSRSVS
CCCCCCCCCCCCCCC		30.6128889911
282PhosphorylationGHQSTNQSRSVSPQD
CCCCCCCCCCCCHHH		28.7021440633
284PhosphorylationQSTNQSRSVSPQDIQ
CCCCCCCCCCHHHHH		31.9922369663
286PhosphorylationTNQSRSVSPQDIQER
CCCCCCCCHHHHHHH		20.3522369663
299PhosphorylationERRQRDDSSDSSKQS
HHHHHCCCCHHHHHH		40.0919779198
346PhosphorylationTPEVQEGTPTSNSES
CCCCCCCCCCCCCHH		23.7321440633
348PhosphorylationEVQEGTPTSNSESSA
CCCCCCCCCCCHHHH		40.1423749301
354PhosphorylationPTSNSESSAQQYDNE
CCCCCHHHHHHHCCC		26.5021440633
369PhosphorylationAPGARQKSPSQGSVS
CCCCCCCCCCCCCHH		22.8020377248
371PhosphorylationGARQKSPSQGSVSRS
CCCCCCCCCCCHHHH		55.0220377248
374PhosphorylationQKSPSQGSVSRSLWS
CCCCCCCCHHHHHHH		14.8524961812
376PhosphorylationSPSQGSVSRSLWSFV
CCCCCCHHHHHHHHH		20.1824961812
378PhosphorylationSQGSVSRSLWSFVSD
CCCCHHHHHHHHHHH		27.0424961812
381PhosphorylationSVSRSLWSFVSDVKA
CHHHHHHHHHHHHHH		22.5128889911
384PhosphorylationRSLWSFVSDVKAGLL
HHHHHHHHHHHHHHC		34.3824961812
427PhosphorylationKKSTHKITNRGQAED
HHHCCCCCCCCCCCC		24.5422369663
435PhosphorylationNRGQAEDSGDDSSLN
CCCCCCCCCCCCCCC		35.3122369663
439PhosphorylationAEDSGDDSSLNMRKF
CCCCCCCCCCCHHCE		41.2720377248
440PhosphorylationEDSGDDSSLNMRKFK
CCCCCCCCCCHHCEE		30.6620377248
461PhosphorylationKDNAGNNSLTDESGH
CCCCCCCCCCCCHHC		36.3222369663
463PhosphorylationNAGNNSLTDESGHRT
CCCCCCCCCCHHCCC		37.2322369663
493PhosphorylationGEPDNDNSSVKNSVE
CCCCCCCCCCCCCEE		39.1025521595
494PhosphorylationEPDNDNSSVKNSVEM
CCCCCCCCCCCCEEC		43.2822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TDA11_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TDA11_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TDA11_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRS2_YEASTSRS2genetic
21459050
TDA11_YEASTTDA11physical
22875988
RKM3_YEASTRKM3genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
RV161_YEASTRVS161genetic
27708008
PEX19_YEASTPEX19genetic
27708008
SWI4_YEASTSWI4genetic
27708008
RAD4_YEASTRAD4genetic
27708008
CGR1_YEASTCGR1genetic
27708008
SGF73_YEASTSGF73genetic
27708008
RL9A_YEASTRPL9Agenetic
27708008
RTF1_YEASTRTF1genetic
27708008
ELP2_YEASTELP2genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
ILM1_YEASTILM1genetic
27708008
DHOM_YEASTHOM6genetic
27708008
TPO5_YEASTTPO5genetic
27708008
SAC1_YEASTSAC1genetic
27708008
NKP2_YEASTNKP2genetic
27708008
FKS1_YEASTFKS1genetic
27708008
PFA4_YEASTPFA4genetic
27708008
VPS68_YEASTVPS68genetic
27708008
PT127_YEASTPET127genetic
27708008
SFL1_YEASTSFL1genetic
27708008
YO289_YEASTYOR289Wgenetic
27708008
DGK1_YEASTDGK1genetic
27708008
SRL4_YEASTSRL4genetic
27708008
NIP80_YEASTNIP100genetic
27708008
YP063_YEASTYPR063Cgenetic
27708008
YP078_YEASTYPR078Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TDA11_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; THR-236; SER-244;SER-286; SER-440 AND SER-494, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-236, AND MASSSPECTROMETRY.

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