TPO5_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPO5_YEAST
• UniProt AC: P36029
• Protein Name: Polyamine transporter TPO5
• Gene Name: TPO5
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 618
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Required for polyamine transport. Transports putrescine effectively and spermidine less effectively..
• Protein Sequence: MPEYTLLADNIRENIVHFDPNGLFDNLHTIVHEDDSQENEEAEHFNYDQVLDKSLLSRGSIVGLGLGLMSPVLGMCTSMAIGLINGGPLTIMLGFLISGVCIWFSSLSLGEIVSKFPMELHVGSAMLAPEKLKLVCSWYTGWLMLIGNWTMSTSITFAGAQLTISLILMTNSNLISEAHLIFYTVIVFYLVVTVVGLVNLKFARFIETINKVCVYWIIYAIIFIDILLLVFHKGKFRSLKYALFHFDNNLSGYKSAFLSFIIGFQQSNFTLQGFSMLPALADEVKVPEKDIPRGMSNAVLLSAFSGVIFLIPIMLILPDNDLLFTNHKVLPIVNIFTKSTDSVVLSFFLVLLILGNLLFSGIGSITTSSRAVYSFSRDQAIPYYDKWTYVEPDSQSKVPKNSVVLSMIISYFLGLLALISTAAFNAFIGAAVLCLCSATFIPLVLVLFTRRRAIRSAPVKIRYKFGWFINIVSIVWLLLSMVSVCLPTQVPVTFKTMNYALMVYVFCILVITGLYFKWGKYNFRLPLADDIKAPIPSDAEETVFELEDSNVEHTLNSGTTVKESVENNSEEGFIKVHPKSSTENPFEENEENVITDYGDEHHTAEQEFDLADDRRYDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
386	Ubiquitination	QAIPYYDKWTYVEPD CCCCCCCCCEEECCC	25.88	23749301
537	Phosphorylation	DIKAPIPSDAEETVF CCCCCCCCCCCCCEE	50.61	20377248
542	Phosphorylation	IPSDAEETVFELEDS CCCCCCCCEEEEECC	23.23	21551504
564	Phosphorylation	SGTTVKESVENNSEE CCCCEEHHHCCCCCC	29.07	29136822
569	Phosphorylation	KESVENNSEEGFIKV EHHHCCCCCCCCEEE	48.91	22369663
575	Ubiquitination	NSEEGFIKVHPKSST CCCCCCEEECCCCCC	32.03	23749301
575	Acetylation	NSEEGFIKVHPKSST CCCCCCEEECCCCCC	32.03	24489116
580	Phosphorylation	FIKVHPKSSTENPFE CEEECCCCCCCCCCC	47.12	21440633
581	Phosphorylation	IKVHPKSSTENPFEE EEECCCCCCCCCCCC	45.96	19779198
582	Phosphorylation	KVHPKSSTENPFEEN EECCCCCCCCCCCCC	47.04	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPO5_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPO5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPO5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSG2_YEAST	CSG2	genetic	20093466
PMP3_YEAST	PMP3	genetic	20093466
RT103_YEAST	RTT103	genetic	20093466
GMC1_YEAST	GMC1	genetic	20093466
ARI1_YEAST	ARI1	genetic	20093466
ATE1_YEAST	ATE1	genetic	20093466
FHP_YEAST	YHB1	genetic	20093466
REV7_YEAST	REV7	genetic	20093466
YIT6_YEAST	YIR016W	genetic	20093466
INA22_YEAST	INA22	genetic	20093466
GYP6_YEAST	GYP6	genetic	20093466
RSC2_YEAST	RSC2	genetic	20093466
ELO3_YEAST	ELO3	genetic	20093466
DDC1_YEAST	DDC1	genetic	20093466
YP098_YEAST	YPR098C	genetic	20093466
MST28_YEAST	MST28	physical	16093310
MST27_YEAST	MST27	physical	16093310
LAC1_YEAST	LAC1	physical	16093310

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-537 AND SER-569, ANDMASS SPECTROMETRY.
PubMed: 18407956

"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-569, AND MASSSPECTROMETRY.
PubMed: 12872131