VPS68_YEAST - dbPTM
VPS68_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS68_YEAST
UniProt AC Q12016
Protein Name Vacuolar protein sorting-associated protein 68
Gene Name VPS68
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 184
Subcellular Localization Vacuole membrane
Multi-pass membrane protein. Mitochondrion .
Protein Description Involved in vacuolar protein sorting..
Protein Sequence MEADDHVSLFRFPFKIPTFRGIRKGGVYLSGALYALGFWIFLDAVLYSRYSNASDVHVTFIDWIPFLCSTLGTLIVNSIEKNRLLQGALSSDGGAFGSGVGDLDSSMAWQARTVLFFGFALLAGGLSGSIVVLIIKFLVKDYNTYPTLGMGVNNVLGNVCILLSCVVLWIAQNVEDEYSYSLTL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEADDHVS
-------CCCCCCCE		9.6322814378
1Oxidation-------MEADDHVS
-------CCCCCCCE		9.6315665377
8PhosphorylationMEADDHVSLFRFPFK
CCCCCCCEECCCCCC		20.5422369663
15UbiquitinationSLFRFPFKIPTFRGI
EECCCCCCCCCCCCC		48.2724961812
15AcetylationSLFRFPFKIPTFRGI
EECCCCCCCCCCCCC		48.2724489116
52N-linked_GlycosylationVLYSRYSNASDVHVT
HHHHCCCCCCCCEEE		34.23-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS68_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS68_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS68_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS55_YEASTVPS55physical
18216282
COT1_YEASTCOT1physical
18467557
UIP3_YEASTUIP3physical
18719252
VPS8_YEASTVPS8genetic
21987634
CSG2_YEASTCSG2genetic
21987634
VATB_YEASTVMA2genetic
21987634
UBP4_YEASTDOA4genetic
21987634
RGP1_YEASTRGP1genetic
21987634
SWA2_YEASTSWA2genetic
21987634
PEP7_YEASTPEP7genetic
21987634
NHX1_YEASTNHX1genetic
21987634
VAC8_YEASTVAC8genetic
21987634
UBP3_YEASTUBP3genetic
21987634
UBP6_YEASTUBP6genetic
21987634
ATC1_YEASTPMR1genetic
21987634
VMA22_YEASTVMA22genetic
21987634
VPH2_YEASTVPH2genetic
21987634
DOA1_YEASTDOA1genetic
21987634
RIC1_YEASTRIC1genetic
21987634
CDC42_YEASTCDC42genetic
21987634
YPT6_YEASTYPT6genetic
21987634
SCS7_YEASTSCS7genetic
21987634
VPS27_YEASTVPS27genetic
21987634
VPS21_YEASTVPS21genetic
21987634
SUR1_YEASTSUR1genetic
21987634
BECN1_YEASTVPS30genetic
21987634
VPS4_YEASTVPS4genetic
21987634
PEX22_YEASTPEX22genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
DAL81_YEASTDAL81genetic
27708008
VPS55_YEASTVPS55genetic
27708008
VPS8_YEASTVPS8genetic
27708008
NU170_YEASTNUP170genetic
27708008
ECM8_YEASTECM8genetic
27708008
PAT1_YEASTPAT1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
TMS1_YEASTTMS1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
LSM6_YEASTLSM6genetic
27708008
ERD1_YEASTERD1genetic
27708008
VPS60_YEASTVPS60genetic
27708008
BCK2_YEASTBCK2genetic
27708008
RL29_YEASTRPL29genetic
27708008
MMS2_YEASTMMS2genetic
27708008
PAN2_YEASTPAN2genetic
27708008
MRM2_YEASTMRM2genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
VMA21_YEASTVMA21genetic
27708008
MAL12_YEASTMAL12genetic
27708008
HSE1_YEASTHSE1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
VPS24_YEASTVPS24genetic
27708008
DOA1_YEASTDOA1genetic
27708008
DID2_YEASTDID2genetic
27708008
VPS13_YEASTVPS13genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
GLYC_YEASTSHM2genetic
27708008
SRN2_YEASTSRN2genetic
27708008
VTA1_YEASTVTA1genetic
27708008
ECM19_YEASTECM19genetic
27708008
VPS9_YEASTVPS9genetic
27708008
NU188_YEASTNUP188genetic
27708008
MPIP_YEASTMIH1genetic
27708008
PKR1_YEASTPKR1genetic
27708008
EAR1_YEASTEAR1genetic
27708008
YNO4_YEASTYNL144Cgenetic
27708008
CUZ1_YEASTCUZ1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
BUD21_YEASTBUD21genetic
27708008
VPS21_YEASTVPS21genetic
27708008
PMA2_YEASTPMA2genetic
27708008
KES1_YEASTKES1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
USV1_YEASTUSV1genetic
27708008
MRL1_YEASTMRL1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS68_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION AT SER-8,AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION AT SER-8,AND MASS SPECTROMETRY.

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