| UniProt ID | NU170_YEAST | |
|---|---|---|
| UniProt AC | P38181 | |
| Protein Name | Nucleoporin NUP170 | |
| Gene Name | NUP170 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1502 | |
| Subcellular Localization |
Nucleus, nuclear pore complex. Nucleus membrane Peripheral membrane protein Cytoplasmic side. Nucleus membrane Peripheral membrane protein Nucleoplasmic side. Symmetric distribution. |
|
| Protein Description | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.. | |
| Protein Sequence | MFQSFFHNNGPAAAGETFSDSRSYPLTNHQEVPRNGLNELASSATKAQQQPTHILNSYPITGSNPLMRASAMGATSGSINPNMSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPVLDERSYYNSGVDYNFSREKNGLGAFTPFEKQDVFNIPDEILHEFSTSQTKTDMGIFPELNRCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMELFMFAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHERSGRIFFAGQASGLNIWELHYSGSDDWFNSKCSKVCLTKSALLSLLPTNMLSQIPGVDFIQALFEDNSNGNGGFSQETITQLTIDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISRIIGTTTARAAPILGPKYLKIVKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEVIQQELLHQQQEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQQTHQQEKKENSSVTGTTATAGSKTVKQQPVTLQHKLFVSVPDYGILKTHGKYVENATFLETAGPVQQIIPLSGLFNATTKPQGFANEFATQYTSETLRVAVLTSTSIEIYKYRTPDEIFEDLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRYSVSTVSSLLSKPTLSTATTNLQQSITGFSKPSPANKEDFDLDDVILSPRFYGIALLITRLLRDIWGRHVFMTFTDNRVTSHAFISSSDPITPSINNLKSDEISQNRNIISKVSISKDCIEYYLSSINILNEFFITYGDSISQISAPYVLANNSNGRVIDKTEEVANQAESIAINAMIKMVQSIKEGLSFLNVLYEESEVEGFDNQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNDKTKSLIREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGLRNYDSLNYHLKNATALLEQIVDDLSIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLACQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAEKKQSSKTQNQISISNDDEVKLRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNILWVYYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLASRIQDACEVAGIQGDILSLVYTDARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEIALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMNFINLLSNVLIKIGKNVQDSEFIFPIFELFPIVCNFFYETLPKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSDNSVFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLGICFYKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 43 | Phosphorylation | GLNELASSATKAQQQ CHHHHHHHCHHHHHC | 34.06 | 23749301 | |
| 45 | Phosphorylation | NELASSATKAQQQPT HHHHHHCHHHHHCCC | 28.94 | 21082442 | |
| 70 | Phosphorylation | SNPLMRASAMGATSG CCHHHCHHHCCCCCC | 14.39 | 19779198 | |
| 76 | Phosphorylation | ASAMGATSGSINPNM HHHCCCCCCCCCCCC | 29.97 | 27017623 | |
| 78 | Phosphorylation | AMGATSGSINPNMSN HCCCCCCCCCCCCCC | 20.96 | 19779198 | |
| 84 | Phosphorylation | GSINPNMSNMNEHIR CCCCCCCCCCCCCEE | 39.30 | 19779198 | |
| 106 | Acetylation | KPLDLAGKYIDHLQH CCHHHHHHHHHHHCC | 33.16 | 22865919 | |
| 146 | Phosphorylation | KNGLGAFTPFEKQDV CCCCCCCCCCCCCCC | 26.91 | 27214570 | |
| 416 | Acetylation | AAPILGPKYLKIVKI CCCCCCCCEEEEEEE | 62.51 | 24489116 | |
| 492 | Phosphorylation | QQEQAKRSFPFFSNL HHHHHHHHCHHHHHH | 36.24 | 29650682 | |
| 497 | Phosphorylation | KRSFPFFSNLMSSEP HHHCHHHHHHCCCCC | 29.45 | 29650682 | |
| 501 | Phosphorylation | PFFSNLMSSEPVLLK HHHHHHCCCCCEEHH | 34.41 | 29650682 | |
| 502 | Phosphorylation | FFSNLMSSEPVLLKF HHHHHCCCCCEEHHH | 31.77 | 29650682 | |
| 548 | Ubiquitination | QTHQQEKKENSSVTG HHHHHHHHHHCCCCC | 62.47 | 23749301 | |
| 551 | Phosphorylation | QQEKKENSSVTGTTA HHHHHHHCCCCCCCC | 27.55 | 23749301 | |
| 552 | Phosphorylation | QEKKENSSVTGTTAT HHHHHHCCCCCCCCC | 34.97 | 23749301 | |
| 554 | Phosphorylation | KKENSSVTGTTATAG HHHHCCCCCCCCCCC | 30.66 | 27717283 | |
| 563 | Ubiquitination | TTATAGSKTVKQQPV CCCCCCCCCCCCCCE | 57.32 | 23749301 | |
| 579 | Phosphorylation | LQHKLFVSVPDYGIL EEEEEEEECCCCCCC | 22.16 | 22369663 | |
| 583 | Phosphorylation | LFVSVPDYGILKTHG EEEECCCCCCCHHCC | 10.45 | 22369663 | |
| 799 | Phosphorylation | TFTDNRVTSHAFISS EEECCCEEEEEEECC | 16.14 | 26447709 | |
| 800 | Phosphorylation | FTDNRVTSHAFISSS EECCCEEEEEEECCC | 15.23 | 26447709 | |
| 805 | Phosphorylation | VTSHAFISSSDPITP EEEEEEECCCCCCCC | 19.82 | 26447709 | |
| 806 | Phosphorylation | TSHAFISSSDPITPS EEEEEECCCCCCCCC | 33.66 | 26447709 | |
| 807 | Phosphorylation | SHAFISSSDPITPSI EEEEECCCCCCCCCC | 40.38 | 26447709 | |
| 811 | Phosphorylation | ISSSDPITPSINNLK ECCCCCCCCCCCCCC | 19.17 | 23749301 | |
| 813 | Phosphorylation | SSDPITPSINNLKSD CCCCCCCCCCCCCCH | 29.33 | 23749301 | |
| 950 | Acetylation | DLVKLDFKDLFAPND HHCCCCHHHHCCCCH | 53.87 | 24489116 | |
| 994 | Phosphorylation | ALQERCGSFCSASDI HHHHHHCCCCCHHHH | 27.06 | 30377154 | |
| 1056 | Phosphorylation | EAVSMMLSVNYYPKS HHHHHHHCCCCCHHH | 7.16 | 27017623 | |
| 1185 | Phosphorylation | ETPFILPYLMEKAGS CCCCHHHHHHHHCCC | 18.42 | 19779198 | |
| 1193 | Phosphorylation | LMEKAGSSLKISNIL HHHHCCCCCEECCEE | 32.53 | 19779198 | |
| 1247 | Phosphorylation | NGFCNSVSPLSQKQR CCCCCCCCCCCHHHH | 21.68 | 28889911 | |
| 1252 | Ubiquitination | SVSPLSQKQRIVQLA CCCCCCHHHHHHHHH | 37.86 | 23749301 | |
| 1290 | Acetylation | ARIDSAIKDELIKTL HHHCHHHHHHHHHHC | 44.88 | 24489116 | |
| 1295 | Acetylation | AIKDELIKTLDGKIL HHHHHHHHHCCCCEE | 56.51 | 24489116 | |
| 1360 | Phosphorylation | NTGKKEDSMNFINLL CCCCCCHHHHHHHHH | 19.40 | 26447709 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NU170_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NU170_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NU170_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1247, AND MASSSPECTROMETRY. | |
