| UniProt ID | IMA1_YEAST | |
|---|---|---|
| UniProt AC | Q02821 | |
| Protein Name | Importin subunit alpha | |
| Gene Name | SRP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 542 | |
| Subcellular Localization | Cytoplasm, perinuclear region. Mainly localized at the periphery of the nucleus. | |
| Protein Description | Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).. | |
| Protein Sequence | MDNGTDSSTSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFIPPTDGADSDEEDESSVSADQQFYSQLQQELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEEDAVDETMAPQNAGNTFGFGSNVNQQFNFN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDNGTDSS -------CCCCCCCC | 9.01 | 22814378 | |
| 5 | Phosphorylation | ---MDNGTDSSTSKF ---CCCCCCCCCCCC | 38.67 | 30377154 | |
| 7 | Phosphorylation | -MDNGTDSSTSKFVP -CCCCCCCCCCCCCH | 35.04 | 30377154 | |
| 8 | Phosphorylation | MDNGTDSSTSKFVPE CCCCCCCCCCCCCHH | 39.24 | 30377154 | |
| 9 | Phosphorylation | DNGTDSSTSKFVPEY CCCCCCCCCCCCHHH | 39.63 | 30377154 | |
| 11 | Acetylation | GTDSSTSKFVPEYRR CCCCCCCCCCHHHHC | 50.93 | 24489116 | |
| 28 | Phosphorylation | FKNKGRFSADELRRR CCCCCCCCHHHHHHH | 33.19 | 28889911 | |
| 38 | Phosphorylation | ELRRRRDTQQVELRK HHHHHHHHHHHHHHH | 21.06 | 28889911 | |
| 54 | Acetylation | KRDEALAKRRNFIPP HHHHHHHHHCCCCCC | 53.38 | 25381059 | |
| 67 | Phosphorylation | PPTDGADSDEEDESS CCCCCCCCCCCCCCC | 46.52 | 9258433 | |
| 351 | Phosphorylation | PALRLLLSSPKENIK HHHHHHHCCCCHHHC | 44.56 | 17330950 | |
| 354 | 2-Hydroxyisobutyrylation | RLLLSSPKENIKKEA HHHHCCCCHHHCHHH | 66.40 | - | |
| 354 | Acetylation | RLLLSSPKENIKKEA HHHHCCCCHHHCHHH | 66.40 | 24489116 | |
| 398 | Acetylation | LLEVAEYKTKKEACW HHHHHCCCCHHHHHH | 45.43 | 24489116 | |
| 398 | 2-Hydroxyisobutyrylation | LLEVAEYKTKKEACW HHHHHCCCCHHHHHH | 45.43 | - | |
| 398 | Ubiquitination | LLEVAEYKTKKEACW HHHHHCCCCHHHHHH | 45.43 | 23749301 | |
| 398 | Succinylation | LLEVAEYKTKKEACW HHHHHCCCCHHHHHH | 45.43 | 23954790 | |
| 479 | Acetylation | ENADFIEKAGGMEKI CCHHHHHHCCCHHHH | 47.73 | 24489116 | |
| 485 | Acetylation | EKAGGMEKIFNCQQN HHCCCHHHHHCCCCC | 43.64 | 24489116 | |
| 496 | Ubiquitination | CQQNENDKIYEKAYK CCCCCCCHHHHHHHH | 59.79 | 23749301 | |
| 496 | Acetylation | CQQNENDKIYEKAYK CCCCCCCHHHHHHHH | 59.79 | 24489116 | |
| 500 | Ubiquitination | ENDKIYEKAYKIIET CCCHHHHHHHHHHHH | 39.79 | 22817900 | |
| 500 | Acetylation | ENDKIYEKAYKIIET CCCHHHHHHHHHHHH | 39.79 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IMA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IMA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IMA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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