| UniProt ID | DNPEP_YEAST | |
|---|---|---|
| UniProt AC | P38821 | |
| Protein Name | Aspartyl aminopeptidase 4 | |
| Gene Name | APE4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 490 | |
| Subcellular Localization | Cytoplasm . Vacuole lumen . In growing conditions, a small portion localizes in the vacuole, but actively transported to the vacuole under nutrient starvation conditions. | |
| Protein Description | Aspartyl aminopeptidase that contributes to peptide degradation both in the cytosol and the vacuole. Cells may respond to environmental conditions by changing the distributions of the cytosolic enzyme to the vacuole when cells need more active vacuolar degradation.. | |
| Protein Sequence | MFRIQLRTMSSKTCKSDYPKEFVSFLNSSHSPYHTVHNIKKHLVSNGFKELSERDSWAGHVAQKGKYFVTRNGSSIIAFAVGGKWEPGNPIAITGAHTDSPALRIKPISKRVSEKYLQVGVETYGGAIWHSWFDKDLGVAGRVFVKDAKTGKSIARLVDLNRPLLKIPTLAIHLDRDVNQKFEFNRETQLLPIGGLQEDKTEAKTEKEINNGEFTSIKTIVQRHHAELLGLIAKELAIDTIEDIEDFELILYDHNASTLGGFNDEFVFSGRLDNLTSCFTSMHGLTLAADTEIDRESGIRLMACFDHEEIGSSSAQGADSNFLPNILERLSILKGDGSDQTKPLFHSAILETSAKSFFLSSDVAHAVHPNYANKYESQHKPLLGGGPVIKINANQRYMTNSPGLVLVKRLAEAAKVPLQLFVVANDSPCGSTIGPILASKTGIRTLDLGNPVLSMHSIRETGGSADLEFQIKLFKEFFERYTSIESEIVV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Acetylation | HLVSNGFKELSERDS HHHHCCCHHHHHCCC | 60.18 | 24489116 | |
| 74 | Phosphorylation | YFVTRNGSSIIAFAV EEEECCCCEEEEEEE | 23.16 | 22369663 | |
| 75 | Phosphorylation | FVTRNGSSIIAFAVG EEECCCCEEEEEEEC | 21.29 | 22369663 | |
| 109 | Phosphorylation | ALRIKPISKRVSEKY CCCCCCCCHHHHHHH | 23.96 | 19823750 | |
| 113 | Phosphorylation | KPISKRVSEKYLQVG CCCCHHHHHHHHHEE | 32.19 | 19823750 | |
| 150 | Phosphorylation | VFVKDAKTGKSIARL EEEEECCCCCCHHHH | 52.11 | 28889911 | |
| 181 | Acetylation | LDRDVNQKFEFNRET ECCCCHHHEEECCCC | 41.48 | 24489116 | |
| 200 | Acetylation | IGGLQEDKTEAKTEK CCCCCCCCCCCCCHH | 47.73 | 24489116 | |
| 204 | Acetylation | QEDKTEAKTEKEINN CCCCCCCCCHHHHCC | 51.49 | 24489116 | |
| 207 | Acetylation | KTEAKTEKEINNGEF CCCCCCHHHHCCCCC | 69.95 | 24489116 | |
| 342 | Acetylation | GDGSDQTKPLFHSAI CCCCCCCCCCCHHHH | 33.81 | 24489116 | |
| 475 | Acetylation | EFQIKLFKEFFERYT HHHHHHHHHHHHHHH | 65.14 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DNPEP_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DNPEP_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DNPEP_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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