PRI1_YEAST - dbPTM
PRI1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRI1_YEAST
UniProt AC P10363
Protein Name DNA primase small subunit
Gene Name PRI1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 409
Subcellular Localization
Protein Description DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48..
Protein Sequence MTNSVKTNGPSSSDMEYYYKSLYPFKHIFNWLNHSPKPSRDMINREFAMAFRSGAYKRYNSFNSVQDFKAQIEKANPDRFEIGAIYNKPPRERDTLLKSELKALEKELVFDIDMDDYDAFRTCCSGAQVCSKCWKFISLAMKITNTALREDFGYKDFIWVFSGRRGAHCWVSDKRARALTDVQRRNVLDYVNVIRDRNTDKRLALKRPYHPHLARSLEQLKPFFVSIMLEEQNPWEDDQHAIQTLLPALYDKQLIDSLKKYWLDNPRRSSKEKWNDIDQIATSLFKGPKQDSHIIKLRECKEDLVLMTLYPKLDVEVTKQTIHLLKAPFCIHPATGNVCVPIDESFAPEKAPKLIDLQTEMEKNNDVSLTALQPFINQFQAYVSSLLKNELGSVKREREDDDEPASLDF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTNSVKTNG
------CCCCCCCCC		35.8824909858
13PhosphorylationKTNGPSSSDMEYYYK
CCCCCCHHHHHHHHH		45.3630377154
17PhosphorylationPSSSDMEYYYKSLYP
CCHHHHHHHHHHHHC		12.8830377154
18PhosphorylationSSSDMEYYYKSLYPF
CHHHHHHHHHHHHCH		7.3630377154
61PhosphorylationGAYKRYNSFNSVQDF
CHHHHCCCCCCHHHH		19.5028889911
98AcetylationRERDTLLKSELKALE
HHHHHHHHHHHHHHH		45.0224489116
326UbiquitinationKQTIHLLKAPFCIHP
HHHHHHHCCCEEECC		61.4417644757
350UbiquitinationDESFAPEKAPKLIDL
CCCCCCCCCCCHHHH		69.7717644757
406PhosphorylationEDDDEPASLDF----
CCCCCCCCCCC----		38.9022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRI1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRI1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRI1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RFA2_YEASTRFA2physical
9724654
DPOA_YEASTPOL1physical
9724654
DPOA_YEASTPOL1physical
3888995
DPOE_YEASTPOL2physical
3888995
PRI2_YEASTPRI2physical
3888995
PRI2_YEASTPRI2genetic
8436268
DDC1_YEASTDDC1genetic
9311982
ISW1_YEASTISW1physical
16554755
YRA1_YEASTYRA1physical
16554755
GIN4_YEASTGIN4physical
16554755
NAP1_YEASTNAP1physical
16554755
DPOA_YEASTPOL1physical
16554755
RAD24_YEASTRAD24genetic
17314980
RAD9_YEASTRAD9genetic
17314980
SPT2_YEASTSPT2genetic
17314980
SWR1_YEASTSWR1genetic
17314980
SWC3_YEASTSWC3genetic
17314980
NHP10_YEASTNHP10genetic
17314980
IES5_YEASTIES5genetic
17314980
VPS72_YEASTVPS72genetic
17314980
SWC5_YEASTSWC5genetic
17314980
COM1_YEASTSAE2genetic
17314980
MRC1_YEASTMRC1genetic
17314980
RAD51_YEASTRAD51genetic
17314980
RPN4_YEASTRPN4genetic
17314980
MUS81_YEASTMUS81genetic
17314980
XRS2_YEASTXRS2genetic
17314980
RAD54_YEASTRAD54genetic
17314980
IES1_YEASTIES1genetic
17314980
RAD55_YEASTRAD55genetic
17314980
BMH1_YEASTBMH1genetic
17314980
MMS4_YEASTMMS4genetic
17314980
UBP6_YEASTUBP6genetic
17314980
HPC2_YEASTHPC2genetic
17314980
HST4_YEASTHST4genetic
17314980
ESC2_YEASTESC2genetic
17314980
RAD57_YEASTRAD57genetic
17314980
SAS4_YEASTSAS4genetic
17314980
PP4C_YEASTPPH3genetic
17314980
SRB8_YEASTSRB8genetic
17314980
VPS8_YEASTVPS8genetic
17314980
RXT2_YEASTRXT2genetic
17314980
SDS3_YEASTSDS3genetic
17314980
MED31_YEASTSOH1genetic
17314980
HCM1_YEASTHCM1genetic
17314980
PP2A1_YEASTPPH21genetic
17314980
SSN2_YEASTSSN2genetic
17314980
MON1_YEASTMON1genetic
17314980
CHD1_YEASTCHD1genetic
17314980
TPA1_YEASTTPA1genetic
17314980
SA155_YEASTSAP155genetic
17314980
DOT6_YEASTDOT6genetic
17314980
SKI8_YEASTSKI8genetic
17314980
UME6_YEASTUME6genetic
17314980
UBX1_YEASTSHP1genetic
17314980
SNT1_YEASTSNT1genetic
17314980
SIF2_YEASTSIF2genetic
17314980
MTU1_YEASTSLM3genetic
17314980
ISW1_YEASTISW1genetic
17314980
PSA3_YEASTPRE9genetic
17314980
HOS4_YEASTHOS4genetic
17314980
SEM1_YEASTSEM1genetic
17314980
SSF1_YEASTSSF1genetic
17314980
IOC3_YEASTIOC3genetic
17314980
AAKG_YEASTSNF4genetic
17314980
HOS2_YEASTHOS2genetic
17314980
RRM3_YEASTRRM3genetic
17314980
VPS64_YEASTVPS64genetic
17314980
ITC1_YEASTITC1genetic
17314980
H4_YEASTHHF1genetic
17314980
RAD53_YEASTRAD53genetic
9034345
ATR_YEASTMEC1genetic
9034345
MEC3_YEASTMEC3genetic
9034345
LCD1_YEASTLCD1genetic
10950868
MCM2_YEASTMCM2physical
19496828
DPOA_YEASTPOL1physical
19496828
RAD51_YEASTRAD51genetic
25661486
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRI1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-406, AND MASSSPECTROMETRY.

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