| UniProt ID | RAD9_YEAST | |
|---|---|---|
| UniProt AC | P14737 | |
| Protein Name | DNA repair protein RAD9 | |
| Gene Name | RAD9 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1309 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Essential for cell cycle arrest at the G2 stage following DNA damage by X-irradiation or inactivation of DNA ligase.. | |
| Protein Sequence | MSGQLVQWKSSPDRVTQSAIKEALHSPLADGDMNEMNVPVDPLENKVNSTNIIEGSPKANPNPVKFMNTSEIFQKSLGLLDESPRHDDELNIEVGDNDRPNANILHNERTPDLDRIANFFKSNRTPGKENLLTKYQSSDLEDTPLMLRKKMTFQTPTDPLEQKTFKKLKSDTGFCYYGEQNDGEENASLEVTEADATFVQMAERSADNYDCALEGIVTPKRYKDELSKSGGMQDERVQKTQIMISAESPNSISSYDKNKITGNGRTTRNVNKVFNNNEDNIGAIEEKNPVKKKSENYSSDDLRERNNQIIQSNESEEINELEKNLNVSGRENDVNNLDIDINSAVSGTPSRNNAEEEMYSSESVNNREPSKKWIFRYSKDKTENNSNRSTQIVNNPRTQEMPLDSISIDTQPLSKSFNTETNNELETQIIVSSLSQGISAQKGPVFHSTGQTEEIKTQIINSPEQNALNATFETPVTLSRINFEPILEVPETSSPSKNTMSKPSNSSPIPKEKDTFNIHEREVETNNVFSNDIQNSSNAATRDDIIIAGSSDFNEQKEITDRIYLQLSGKQISDSGSDETERMSPNELDTKKESTIMSEVELTQELPEVEEQQDLQTSPKKLVVEEETLMEIKKSKGNSLQLHDDNKECNSDKQDGTESLDVALIEHESKGQSSELQKNLMQLFPSESQEIIQNRRTIKRRQKDTIEIGEEEENRSTKTSPTKHLKRNSDLDAASIKREPSCSITIQTGETGSGKDSKEQSYVFPEGIRTADNSFLSKDDIIFGNAVWCQYTWNYKFYPGILLEVDTNQDGCWIYFETGRSLTKDEDIYYLDIRIGDAVTFDGNEYVVVGLECRSHDLNIIRCIRGYDTVHLKKKNASGLLGKRTLIKALSSISLDLSEWAKRAKIILEDNEKNKGDAYRYLRHPIRGRKSMTNVLSPKKHTDDEKDINTHTEVYNNEIESSSEKKEIVKKDSRDALAEHAGAPSLLFSSGEIRTGNVFDKCIFVLTSLFENREELRQTIESQGGTVIESGFSTLFNFTHPLAKSLVNKGNTDNIRELALKLAWKPHSLFADCRFACLITKRHLRSLKYLETLALGWPTLHWKFISACIEKKRIVPHLIYQYLLPSGESFRLSLDSPSKGGIIKSNNIFSFYTQFLRGSNLRDQICGVKKMLNDYIVIVWGRSELDSFVKFAFACLSAGRMLTIDLPNIDVDDTEPLLNALDSLVPRIGSELSNRKLKFLIYANENNGKSQMKLLERLRSQISLKFKKFNYIFHTESKEWLIQTIINEDTGFHDDITDNDIYNTISEVR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSGQLVQWK ------CCCCCCEEC | 46.69 | 19823750 | |
| 10 | Phosphorylation | GQLVQWKSSPDRVTQ CCCCEECCCCCHHHH | 44.11 | 22369663 | |
| 11 | Phosphorylation | QLVQWKSSPDRVTQS CCCEECCCCCHHHHH | 27.39 | 22369663 | |
| 16 | Phosphorylation | KSSPDRVTQSAIKEA CCCCCHHHHHHHHHH | 20.08 | 23749301 | |
| 18 | Phosphorylation | SPDRVTQSAIKEALH CCCHHHHHHHHHHHC | 23.69 | 24961812 | |
| 26 | Phosphorylation | AIKEALHSPLADGDM HHHHHHCCCCCCCCC | 23.58 | 22369663 | |
| 49 | Phosphorylation | PLENKVNSTNIIEGS CCCCCCCCCCCCCCC | 26.31 | 23749301 | |
| 50 | Phosphorylation | LENKVNSTNIIEGSP CCCCCCCCCCCCCCC | 25.82 | 28889911 | |
| 56 | Phosphorylation | STNIIEGSPKANPNP CCCCCCCCCCCCCCC | 15.50 | 22369663 | |
| 69 | Phosphorylation | NPVKFMNTSEIFQKS CCCCCCCHHHHHHHH | 18.89 | 21440633 | |
| 70 | Phosphorylation | PVKFMNTSEIFQKSL CCCCCCHHHHHHHHH | 24.56 | 28152593 | |
| 76 | Phosphorylation | TSEIFQKSLGLLDES HHHHHHHHHCCCCCC | 19.52 | 28889911 | |
| 83 | Phosphorylation | SLGLLDESPRHDDEL HHCCCCCCCCCCCCC | 27.22 | 25704821 | |
| 122 | Phosphorylation | RIANFFKSNRTPGKE HHHHHHHHCCCCCCH | 26.79 | 30377154 | |
| 125 | Phosphorylation | NFFKSNRTPGKENLL HHHHHCCCCCCHHCH | 40.41 | 21440633 | |
| 135 | Phosphorylation | KENLLTKYQSSDLED CHHCHHHHHCCCCCC | 14.37 | 20377248 | |
| 137 | Phosphorylation | NLLTKYQSSDLEDTP HCHHHHHCCCCCCCC | 23.80 | 20377248 | |
| 138 | Phosphorylation | LLTKYQSSDLEDTPL CHHHHHCCCCCCCCC | 30.59 | 19823750 | |
| 143 | Phosphorylation | QSSDLEDTPLMLRKK HCCCCCCCCCHHHCC | 14.67 | 21440633 | |
| 152 | Phosphorylation | LMLRKKMTFQTPTDP CHHHCCCCCCCCCCH | 22.82 | 25521595 | |
| 155 | Phosphorylation | RKKMTFQTPTDPLEQ HCCCCCCCCCCHHHH | 24.78 | 21440633 | |
| 188 | Phosphorylation | NDGEENASLEVTEAD CCCCCCCEEEEEHHH | 36.32 | 28889911 | |
| 192 | Phosphorylation | ENASLEVTEADATFV CCCEEEEEHHHHHHH | 18.97 | 11124038 | |
| 205 | Phosphorylation | FVQMAERSADNYDCA HHHHHHHCCCCCCCH | 31.32 | 22890988 | |
| 218 | Phosphorylation | CALEGIVTPKRYKDE CHHCCCCCCHHHHHH | 22.60 | 22890988 | |
| 245 | Phosphorylation | QKTQIMISAESPNSI EEEEEEEECCCCCCC | 14.49 | 19779198 | |
| 248 | Phosphorylation | QIMISAESPNSISSY EEEEECCCCCCCCCC | 29.15 | 21551504 | |
| 251 | Phosphorylation | ISAESPNSISSYDKN EECCCCCCCCCCCCC | 27.51 | 21440633 | |
| 253 | Phosphorylation | AESPNSISSYDKNKI CCCCCCCCCCCCCCC | 23.75 | 21440633 | |
| 254 | Phosphorylation | ESPNSISSYDKNKIT CCCCCCCCCCCCCCC | 35.36 | 19779198 | |
| 255 | Phosphorylation | SPNSISSYDKNKITG CCCCCCCCCCCCCCC | 24.93 | 21440633 | |
| 297 | Phosphorylation | VKKKSENYSSDDLRE CCCCCCCCCHHHHHH | 12.90 | 19795423 | |
| 298 | Phosphorylation | KKKSENYSSDDLRER CCCCCCCCHHHHHHH | 38.58 | 17563356 | |
| 299 | Phosphorylation | KKSENYSSDDLRERN CCCCCCCHHHHHHHH | 25.45 | 17563356 | |
| 312 | Phosphorylation | RNNQIIQSNESEEIN HHHHHHCCCCHHHHH | 31.96 | 22369663 | |
| 315 | Phosphorylation | QIIQSNESEEINELE HHHCCCCHHHHHHHH | 44.79 | 22369663 | |
| 328 | Phosphorylation | LEKNLNVSGRENDVN HHHHCCCCCCCCCCC | 30.93 | 28889911 | |
| 348 | Phosphorylation | INSAVSGTPSRNNAE CHHHCCCCCCCCCHH | 15.58 | 28889911 | |
| 377 | Phosphorylation | SKKWIFRYSKDKTEN CCCEEEEECCCCCCC | 14.88 | 25005228 | |
| 378 | Phosphorylation | KKWIFRYSKDKTENN CCEEEEECCCCCCCC | 30.07 | 25005228 | |
| 382 | Phosphorylation | FRYSKDKTENNSNRS EEECCCCCCCCCCCC | 54.82 | 19779198 | |
| 386 | Phosphorylation | KDKTENNSNRSTQIV CCCCCCCCCCCEEEE | 45.24 | 19779198 | |
| 389 | Phosphorylation | TENNSNRSTQIVNNP CCCCCCCCEEEECCC | 28.99 | 19779198 | |
| 390 | Phosphorylation | ENNSNRSTQIVNNPR CCCCCCCEEEECCCC | 21.05 | 28889911 | |
| 398 | Phosphorylation | QIVNNPRTQEMPLDS EEECCCCCCCCCCCC | 30.09 | 28889911 | |
| 410 | Phosphorylation | LDSISIDTQPLSKSF CCCCEECCCCCCCCC | 30.34 | 28889911 | |
| 414 | Phosphorylation | SIDTQPLSKSFNTET EECCCCCCCCCCCCC | 32.70 | 28889911 | |
| 416 | Phosphorylation | DTQPLSKSFNTETNN CCCCCCCCCCCCCCC | 21.98 | 28889911 | |
| 421 | Phosphorylation | SKSFNTETNNELETQ CCCCCCCCCCHHHHH | 41.11 | 15060150 | |
| 427 | Phosphorylation | ETNNELETQIIVSSL CCCCHHHHHHHHEEC | 37.38 | 28889911 | |
| 435 | Phosphorylation | QIIVSSLSQGISAQK HHHHEECCCCCCCCC | 28.45 | 20190278 | |
| 448 | Phosphorylation | QKGPVFHSTGQTEEI CCCCCCCCCCCCHHH | 23.83 | 27017623 | |
| 449 | Phosphorylation | KGPVFHSTGQTEEIK CCCCCCCCCCCHHHH | 25.41 | 30377154 | |
| 457 | Phosphorylation | GQTEEIKTQIINSPE CCCHHHHHHHHCCHH | 30.57 | 28889911 | |
| 462 | Phosphorylation | IKTQIINSPEQNALN HHHHHHCCHHHHCCC | 21.29 | 28152593 | |
| 471 | Phosphorylation | EQNALNATFETPVTL HHHCCCCEEECCCEE | 22.41 | 21440633 | |
| 474 | Phosphorylation | ALNATFETPVTLSRI CCCCEEECCCEECCC | 20.90 | 28152593 | |
| 479 | Phosphorylation | FETPVTLSRINFEPI EECCCEECCCCCEEC | 23.04 | 28889911 | |
| 492 | Phosphorylation | PILEVPETSSPSKNT ECEECCCCCCCCCCC | 28.56 | 22890988 | |
| 493 | Phosphorylation | ILEVPETSSPSKNTM CEECCCCCCCCCCCC | 38.29 | 22890988 | |
| 494 | Phosphorylation | LEVPETSSPSKNTMS EECCCCCCCCCCCCC | 40.38 | 22890988 | |
| 496 | Phosphorylation | VPETSSPSKNTMSKP CCCCCCCCCCCCCCC | 40.25 | 22890988 | |
| 499 | Phosphorylation | TSSPSKNTMSKPSNS CCCCCCCCCCCCCCC | 26.93 | 22369663 | |
| 501 | Phosphorylation | SPSKNTMSKPSNSSP CCCCCCCCCCCCCCC | 39.10 | 22369663 | |
| 504 | Phosphorylation | KNTMSKPSNSSPIPK CCCCCCCCCCCCCCC | 53.75 | 22369663 | |
| 506 | Phosphorylation | TMSKPSNSSPIPKEK CCCCCCCCCCCCCCC | 41.66 | 22369663 | |
| 507 | Phosphorylation | MSKPSNSSPIPKEKD CCCCCCCCCCCCCCC | 30.97 | 22369663 | |
| 530 | Phosphorylation | VETNNVFSNDIQNSS EECCCCCCHHCCCCC | 29.34 | 27017623 | |
| 536 | Phosphorylation | FSNDIQNSSNAATRD CCHHCCCCCCCCCCC | 14.48 | 27017623 | |
| 537 | Phosphorylation | SNDIQNSSNAATRDD CHHCCCCCCCCCCCC | 37.73 | 28889911 | |
| 541 | Phosphorylation | QNSSNAATRDDIIIA CCCCCCCCCCCEEEE | 32.02 | 28889911 | |
| 550 | Phosphorylation | DDIIIAGSSDFNEQK CCEEEECCCCCHHHH | 20.08 | 28889911 | |
| 568 | Phosphorylation | DRIYLQLSGKQISDS HHEEEEECCCCCCCC | 30.86 | 28889911 | |
| 573 | Phosphorylation | QLSGKQISDSGSDET EECCCCCCCCCCCCC | 24.19 | 24961812 | |
| 575 | Phosphorylation | SGKQISDSGSDETER CCCCCCCCCCCCCCC | 33.15 | 21440633 | |
| 577 | Phosphorylation | KQISDSGSDETERMS CCCCCCCCCCCCCCC | 35.90 | 21440633 | |
| 580 | Phosphorylation | SDSGSDETERMSPNE CCCCCCCCCCCCHHH | 33.60 | 24961812 | |
| 584 | Phosphorylation | SDETERMSPNELDTK CCCCCCCCHHHCCCH | 30.69 | 21440633 | |
| 590 | Phosphorylation | MSPNELDTKKESTIM CCHHHCCCHHHHHHC | 57.55 | 24961812 | |
| 595 | Phosphorylation | LDTKKESTIMSEVEL CCCHHHHHHCCHHHH | 23.07 | 27017623 | |
| 598 | Phosphorylation | KKESTIMSEVELTQE HHHHHHCCHHHHHHH | 34.34 | 21440633 | |
| 603 | Phosphorylation | IMSEVELTQELPEVE HCCHHHHHHHCCCHH | 13.39 | 28889911 | |
| 617 | Phosphorylation | EEQQDLQTSPKKLVV HHHHCCCCCCCEEEE | 55.05 | 21440633 | |
| 618 | Phosphorylation | EQQDLQTSPKKLVVE HHHCCCCCCCEEEEC | 23.04 | 21440633 | |
| 639 | Phosphorylation | IKKSKGNSLQLHDDN HHHHCCCCCEECCCC | 26.59 | 25533186 | |
| 674 | Phosphorylation | HESKGQSSELQKNLM ECCCCCCHHHHHHHH | 34.14 | 30377154 | |
| 686 | Phosphorylation | NLMQLFPSESQEIIQ HHHHHCCHHHHHHHH | 42.41 | 21440633 | |
| 688 | Phosphorylation | MQLFPSESQEIIQNR HHHCCHHHHHHHHCH | 37.13 | 25752575 | |
| 705 | Phosphorylation | IKRRQKDTIEIGEEE HHHHHHCCEECCHHH | 27.78 | 19823750 | |
| 716 | Phosphorylation | GEEEENRSTKTSPTK CHHHHCCCCCCCCCH | 45.92 | 19823750 | |
| 717 | Phosphorylation | EEEENRSTKTSPTKH HHHHCCCCCCCCCHH | 34.79 | 20377248 | |
| 719 | Phosphorylation | EENRSTKTSPTKHLK HHCCCCCCCCCHHHC | 39.77 | 21440633 | |
| 720 | Phosphorylation | ENRSTKTSPTKHLKR HCCCCCCCCCHHHCC | 31.93 | 28152593 | |
| 722 | Phosphorylation | RSTKTSPTKHLKRNS CCCCCCCCHHHCCCC | 30.75 | 20377248 | |
| 729 | Phosphorylation | TKHLKRNSDLDAASI CHHHCCCCCCCHHHC | 43.51 | 25521595 | |
| 741 | Phosphorylation | ASIKREPSCSITIQT HHCCCCCCCEEEEEE | 18.75 | 28889911 | |
| 745 | Phosphorylation | REPSCSITIQTGETG CCCCCEEEEEECCCC | 7.25 | 21551504 | |
| 774 | Phosphorylation | GIRTADNSFLSKDDI CCCCCCCCCCCCCCE | 28.28 | 23749301 | |
| 777 | Phosphorylation | TADNSFLSKDDIIFG CCCCCCCCCCCEEEC | 31.84 | 23749301 | |
| 807 | Phosphorylation | GILLEVDTNQDGCWI EEEEEEECCCCCEEE | 39.70 | 28889911 | |
| 931 | Phosphorylation | HPIRGRKSMTNVLSP CCCCCCCCCCCCCCC | 29.49 | 22369663 | |
| 933 | Phosphorylation | IRGRKSMTNVLSPKK CCCCCCCCCCCCCCC | 29.30 | 21440633 | |
| 937 | Phosphorylation | KSMTNVLSPKKHTDD CCCCCCCCCCCCCCC | 30.32 | 22369663 | |
| 942 | Phosphorylation | VLSPKKHTDDEKDIN CCCCCCCCCCCCCCC | 54.76 | 21440633 | |
| 950 | Phosphorylation | DDEKDINTHTEVYNN CCCCCCCCCHHHHCC | 30.43 | 28747907 | |
| 952 | Phosphorylation | EKDINTHTEVYNNEI CCCCCCCHHHHCCCC | 25.71 | 28747907 | |
| 961 | Phosphorylation | VYNNEIESSSEKKEI HHCCCCCCCHHHHHH | 44.84 | 20377248 | |
| 962 | Phosphorylation | YNNEIESSSEKKEIV HCCCCCCCHHHHHHH | 29.71 | 20377248 | |
| 963 | Phosphorylation | NNEIESSSEKKEIVK CCCCCCCHHHHHHHH | 63.82 | 21440633 | |
| 973 | Phosphorylation | KEIVKKDSRDALAEH HHHHHHHHHHHHHHH | 40.72 | 24961812 | |
| 985 | Phosphorylation | AEHAGAPSLLFSSGE HHHCCCCEEEEECCC | 36.85 | 19779198 | |
| 989 | Phosphorylation | GAPSLLFSSGEIRTG CCCEEEEECCCCCCC | 37.09 | 17563356 | |
| 990 | Phosphorylation | APSLLFSSGEIRTGN CCEEEEECCCCCCCC | 32.86 | 25752575 | |
| 1136 | Phosphorylation | SFRLSLDSPSKGGII CEEEECCCCCCCCEE | 36.04 | 22369663 | |
| 1138 | Phosphorylation | RLSLDSPSKGGIIKS EEECCCCCCCCEECC | 48.13 | 22369663 | |
| 1139 | Ubiquitination | LSLDSPSKGGIIKSN EECCCCCCCCEECCC | 65.62 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RAD9_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAD9_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAD9_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; THR-50; SER-56;SER-70; SER-76; SER-83; SER-137; SER-138; THR-155; SER-188; SER-205;THR-218; SER-248; SER-298; SER-312; SER-315; SER-328; THR-348;THR-398; SER-414; SER-416; SER-435; THR-457; SER-462; THR-471;SER-479; SER-507; SER-537; THR-541; SER-550; SER-568; SER-598;THR-603; SER-618; SER-729; SER-741; THR-807; SER-931; SER-937;SER-989; SER-990 AND SER-1136, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-11; SER-298;SER-299; SER-729; SER-989 AND SER-1136, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, AND MASSSPECTROMETRY. | |
