SPP2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPP2_YEAST
• UniProt AC: Q02521
• Protein Name: Pre-mRNA-splicing factor SPP2
• Gene Name: SPP2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 185
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Involved in pre-mRNA splicing; specifically in the final stages of spliceosome maturation. Promotes the first step of splicing..
• Protein Sequence: MSKFSLKLGSKTLKKNISKKTKKKNSLQKANLFDWDDAETASLSHKPQSKIKIQSIDKFDLDEESSSKKKLVIKLSENADTKKNDAPLVEYVTEKEYNEVPVEEFGDALLRGMGWESDSEQDSKGDKTQSRNKDVSNVSQIHPDGLGIGAKLNKAINVEEASFMPVVKIDKITGTKVDDDKKNKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MSKFSLKLGSKTLK -CCCCHHHCCCHHHH	49.99	25381059
11	Acetylation	FSLKLGSKTLKKNIS CHHHCCCHHHHHHHC	56.96	25381059
14	Acetylation	KLGSKTLKKNISKKT HCCCHHHHHHHCHHH	49.35	25381059
117	Phosphorylation	LRGMGWESDSEQDSK HHCCCCCCCCCCCCC	39.67	22369663
119	Phosphorylation	GMGWESDSEQDSKGD CCCCCCCCCCCCCCC	46.57	22890988
123	Phosphorylation	ESDSEQDSKGDKTQS CCCCCCCCCCCCCCC	37.93	24961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPP2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPP2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPP2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP2_YEAST	PRP2	physical	7493316
PRP2_YEAST	PRP2	physical	15542821
CUS2_YEAST	CUS2	physical	16554755

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND MASSSPECTROMETRY.
PubMed: 18407956