CUS2_YEAST - dbPTM
CUS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CUS2_YEAST
UniProt AC P53830
Protein Name Cold sensitive U2 snRNA suppressor 2
Gene Name CUS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 285
Subcellular Localization
Protein Description U2 snRNP protein which helps to refold U2 into a structure favorable for its binding to SF3b and SF3a prior to spliceosome assembly. Mediates functional interactions between U2 RNA and PRP5. Enforces ATP dependence during formation of the prespliceosome by brokering an interaction between PRP5 and the U2 snRNP that depends on correct U2 RNA structure..
Protein Sequence MDADELELKGHLKKLKKEELLRRKQLKESNLQKRELEYNNASKNTSIYISGLPTDKTTKEGLTEQFCKYGMIRTNRDGEPLCKLYVNDKGAFKGDALITYSKEESVTLAIEMMNESIFLGKQIRVERAQFQNKEGDNMHGKENDLKEFNGPEPPIKRLKKAKSEGEGEVIDYNDDESLAKADRTVIFANVFNIYKSYTNDDINDIQEDLLEGCEEIGQVDSISVSPNKGEATVVFKNNKVALQCCKIMTGRYFDGQKLLAFISGDENTSSTSDKNEDSEVEDDLI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationELEYNNASKNTSIYI
HHHHCCCCCCCEEEE		28.6729734811
48PhosphorylationASKNTSIYISGLPTD
CCCCCEEEECCCCCC		6.7119779198
50PhosphorylationKNTSIYISGLPTDKT
CCCEEEECCCCCCCC		19.8019779198
163PhosphorylationKRLKKAKSEGEGEVI
HHHHHHHCCCCCCEE		56.5522369663
184PhosphorylationSLAKADRTVIFANVF
HHHHHCCEEEEEEHH		20.6429688323
194PhosphorylationFANVFNIYKSYTNDD
EEEHHHHHHHCCCCC		8.5929688323
270PhosphorylationSGDENTSSTSDKNED
ECCCCCCCCCCCCCC		29.8621551504
271PhosphorylationGDENTSSTSDKNEDS
CCCCCCCCCCCCCCC		40.4921551504
272PhosphorylationDENTSSTSDKNEDSE
CCCCCCCCCCCCCCC		48.8421551504
278PhosphorylationTSDKNEDSEVEDDLI
CCCCCCCCCCCCCCC		37.0522890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CUS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CUS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CUS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRP5_YEASTPRP5genetic
14610285
SF3B1_YEASTHSH155physical
16554755
PT309_YEASTPET309genetic
19061648
LSM3_YEASTLSM3genetic
19061648
PUF6_YEASTPUF6genetic
19061648
APQ12_YEASTAPQ12genetic
19061648
RU2A_YEASTLEA1genetic
19061648
PRP19_YEASTPRP19genetic
19061648
TOP1_YEASTTOP1genetic
19061648
PRP2_YEASTPRP2genetic
19061648
SF3B1_YEASTHSH155physical
18719252
HUA2_YEASTHUA2physical
18719252
RTG2_YEASTRTG2genetic
27708008
YAR1_YEASTYAR1genetic
27708008
HSP30_YEASTHSP30genetic
27708008
LHP1_YEASTLHP1genetic
27708008
UGA3_YEASTUGA3genetic
27708008
MED5_YEASTNUT1genetic
27708008
YG2G_YEASTYGR079Wgenetic
27708008
VMA21_YEASTVMA21genetic
27708008
AP3B_YEASTAPL6genetic
27708008
YOR1_YEASTYOR1genetic
27708008
NVJ1_YEASTNVJ1genetic
27708008
RPN10_YEASTRPN10genetic
27708008
SKN7_YEASTSKN7genetic
27708008
SYG1_YEASTSYG1genetic
27708008
MAC1_YEASTMAC1genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
RU2A_YEASTLEA1genetic
27708008
SF3B1_YEASTHSH155physical
28062854
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CUS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASSSPECTROMETRY.

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