TPM2_YEAST - dbPTM
TPM2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPM2_YEAST
UniProt AC P40414
Protein Name Tropomyosin-2
Gene Name TPM2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 161
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Involved in cell morphogenesis. Binds to F-actin and stabilizes the actin filaments..
Protein Sequence MEKIKEKLNSLKLESESWQEKYEELREQLKELEQSNTEKENEIKSLSAKNEQLDSEVEKLESQLSDTKQLAEDSNNLRSNNENYTKKNQDLEQQLEDSEAKLKEAMDKLKEADLNSEQMGRRIVALEEERDEWEKKCEEFQSKYEEAQKELDEIANSLENL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationKIKEKLNSLKLESES
HHHHHHHHCCCCCHH		37.0030377154
12AcetylationKEKLNSLKLESESWQ
HHHHHHCCCCCHHHH		50.4524489116
17PhosphorylationSLKLESESWQEKYEE
HCCCCCHHHHHHHHH		43.2524909858
30AcetylationEELREQLKELEQSNT
HHHHHHHHHHHHHCH		61.0124489116
39AcetylationLEQSNTEKENEIKSL
HHHHCHHHHHHHHHH		64.8924489116
39UbiquitinationLEQSNTEKENEIKSL
HHHHCHHHHHHHHHH		64.8923749301
44AcetylationTEKENEIKSLSAKNE
HHHHHHHHHHHHHHH		38.8824489116
45PhosphorylationEKENEIKSLSAKNEQ
HHHHHHHHHHHHHHH		32.9722369663
47PhosphorylationENEIKSLSAKNEQLD
HHHHHHHHHHHHHHH		44.2622369663
49SuccinylationEIKSLSAKNEQLDSE
HHHHHHHHHHHHHHH		58.6123954790
55PhosphorylationAKNEQLDSEVEKLES
HHHHHHHHHHHHHHH		52.7322369663
59AcetylationQLDSEVEKLESQLSD
HHHHHHHHHHHHHHH		63.8324489116
62PhosphorylationSEVEKLESQLSDTKQ
HHHHHHHHHHHHHHH		47.0222369663
65PhosphorylationEKLESQLSDTKQLAE
HHHHHHHHHHHHHHH		35.2822369663
67PhosphorylationLESQLSDTKQLAEDS
HHHHHHHHHHHHHHH		19.8122369663
68UbiquitinationESQLSDTKQLAEDSN
HHHHHHHHHHHHHHH		48.5924961812
87AcetylationNNENYTKKNQDLEQQ
CCCHHHHHHHHHHHH		52.6324489116
87UbiquitinationNNENYTKKNQDLEQQ
CCCHHHHHHHHHHHH		52.6323749301
116PhosphorylationLKEADLNSEQMGRRI
HHHCCCCHHHHHHHH		36.1828889911
157PhosphorylationELDEIANSLENL---
HHHHHHHHHHCC---		28.2125521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPM2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPM2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPM2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TPM2_YEASTTPM2physical
11087867
SRO9_YEASTSRO9genetic
9383048
TPM1_YEASTTPM1genetic
7844152
TPM2_YEASTTPM2physical
18467557
TPM2_YEASTTPM2physical
18540067
YAJ3_YEASTYAR023Cgenetic
20093466
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
STE50_YEASTSTE50genetic
20093466
YD180_YEASTYDL180Wgenetic
20093466
UBP1_YEASTUBP1genetic
20093466
CTU1_YEASTNCS6genetic
20093466
MMS2_YEASTMMS2genetic
20093466
PHB2_YEASTPHB2genetic
20093466
YHA8_YEASTYHL008Cgenetic
20093466
YJ24_YEASTKCH1genetic
20093466
YL271_YEASTYLR271Wgenetic
20093466
SAS2_YEASTSAS2genetic
20093466
PABC_YEASTABZ2genetic
20093466
OCA1_YEASTOCA1genetic
20093466
TPM1_YEASTTPM1genetic
20093466
TGL5_YEASTTGL5genetic
20093466
FYV12_YEASTFYV12genetic
20093466
SYT1_YEASTSYT1genetic
20093466
SEC6_YEASTSEC6genetic
12913108
TPM2_YEASTTPM2physical
22615397
SGF29_YEASTSGF29genetic
27708008
YAJ3_YEASTYAR023Cgenetic
27708008
URA7_YEASTURA7genetic
27708008
VAM6_YEASTVAM6genetic
27708008
YD180_YEASTYDL180Wgenetic
27708008
HOSC_YEASTLYS20genetic
27708008
MMS2_YEASTMMS2genetic
27708008
PHB2_YEASTPHB2genetic
27708008
BYE1_YEASTBYE1genetic
27708008
YKR18_YEASTYKR018Cgenetic
27708008
YL012_YEASTYLR012Cgenetic
27708008
YL271_YEASTYLR271Wgenetic
27708008
ELP1_YEASTIKI3genetic
27708008
SAS2_YEASTSAS2genetic
27708008
TPM1_YEASTTPM1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
STD1_YEASTSTD1genetic
27708008
TGL5_YEASTTGL5genetic
27708008
SYT1_YEASTSYT1genetic
27708008
COQ6_YEASTCOQ6genetic
27453043
VPS1_YEASTVPS1genetic
27453043
BUB1_YEASTBUB1genetic
27453043
PPA3_YEASTPHO3genetic
27453043
MTM1_YEASTMTM1genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPM2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; SER-116 AND SER-157,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, AND MASSSPECTROMETRY.

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