PPA3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPA3_YEAST
• UniProt AC: P24031
• Protein Name: Constitutive acid phosphatase
• Gene Name: PHO3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 467
• Protein Sequence: MFKSVVYSVLAAALVNAGTIPLGELADVAKIGTQEDIFPFLGGAGPYFSFPGDYGISRDLPEGCEMKQLQMLARHGERYPTYSKGATIMKTWYKLSNYTRQFNGSLSFLNDDYEFFIRDDDDLEMETTFANSDNVLNPYTGEMDAKRHAREFLAQYGYMFENQTSFPIFAASSERVHDTAQYFIDGLGDQFNISLQTVSEAMSAGANTLSAGNACPGWDEDANDDILDKYDTTYLDDIAKRLNKENKGLNLTSKDANTLFAWCAYELNARGYSDVCDIFTEDELVRYSYGQDLVSFYQDGPGYDMIRSVGANLFNATLKLLKQSETQDLKVWLSFTHDTDILNYLTTAGIIDDKNNLTAEYVPFMGNTFHKSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYDYAEKRVAGTDFLKVCNVSSVSNVTELTFYWDWNTTHYNDTLLKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MFKSVVYSVLAAAL -CCHHHHHHHHHHHH	7.30	30377154
8	Phosphorylation	MFKSVVYSVLAAALV CCHHHHHHHHHHHHH	10.07	30377154
84	Acetylation	ERYPTYSKGATIMKT CCCCCCCCCCCHHHH	42.00	24489116
90	Acetylation	SKGATIMKTWYKLSN CCCCCHHHHHHHHHH	31.86	24489116
97	N-linked_Glycosylation	KTWYKLSNYTRQFNG HHHHHHHHHHHHCCC	53.27	-
103	N-linked_Glycosylation	SNYTRQFNGSLSFLN HHHHHHCCCCEEECC	30.70	-
162	N-linked_Glycosylation	QYGYMFENQTSFPIF HHCCCCCCCCCCCEE	38.88	-
192	N-linked_Glycosylation	DGLGDQFNISLQTVS HCCHHHCEEEHHHHH	19.80	-
230	Phosphorylation	NDDILDKYDTTYLDD CCCHHHHCCCHHHHH	20.42	22369663
232	Phosphorylation	DILDKYDTTYLDDIA CHHHHCCCHHHHHHH	17.79	22369663
233	Phosphorylation	ILDKYDTTYLDDIAK HHHHCCCHHHHHHHH	21.13	22369663
234	Phosphorylation	LDKYDTTYLDDIAKR HHHCCCHHHHHHHHH	15.38	22369663
250	N-linked_Glycosylation	NKENKGLNLTSKDAN CHHCCCCCCCCCCHH	50.36	-
315	N-linked_Glycosylation	SVGANLFNATLKLLK HHHHHHHHHHHHHHH	34.87	-
356	N-linked_Glycosylation	GIIDDKNNLTAEYVP CCCCCCCCEEEEEEE	44.50	-
390	N-linked_Glycosylation	TEKFQCSNDTYVRYV EEEEECCCCCEEEEE	53.95	-
432	Phosphorylation	AEKRVAGTDFLKVCN HHHHCCCCCEEEECC	17.53	19795423
439	N-linked_Glycosylation	TDFLKVCNVSSVSNV CCEEEECCCCCCCCC	39.43	-
445	N-linked_Glycosylation	CNVSSVSNVTELTFY CCCCCCCCCEEEEEE	42.44	-
456	N-linked_Glycosylation	LTFYWDWNTTHYNDT EEEEEECCCCCCCCC	32.40	-
461	N-linked_Glycosylation	DWNTTHYNDTLLKQ- ECCCCCCCCCCCCC-	28.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPA3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPA3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPA3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHO81_YEAST	PHO81	genetic	15866881
PP2C4_YEAST	PTC4	genetic	19269370
PP11_YEAST	SIT4	genetic	19269370
YPD1_YEAST	YPD1	genetic	19269370
PIL1_YEAST	PIL1	genetic	19269370
PDK1_YEAST	PKP1	genetic	19269370
PIG2_YEAST	PIG2	genetic	19269370
LSB6_YEAST	LSB6	genetic	19269370
F26_YEAST	FBP26	genetic	19269370
IRS4_YEAST	IRS4	genetic	19269370
PIG1_YEAST	PIG1	genetic	19269370
GLC8_YEAST	GLC8	genetic	19269370
COG5_YEAST	COG5	genetic	19269370
PTPA2_YEAST	RRD2	genetic	19269370
ATG31_YEAST	ATG31	genetic	20093466
FYV4_YEAST	FYV4	genetic	20093466
YIH7_YEAST	YIL077C	genetic	20093466
AIM21_YEAST	AIM21	genetic	20093466
ACE2_YEAST	ACE2	genetic	20093466
MED9_YEAST	CSE2	genetic	20093466
ACON2_YEAST	ACO2	genetic	21623372
NRG2_YEAST	NRG2	genetic	21127252
AKL1_YEAST	AKL1	genetic	21127252

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.