PDK1_YEAST - dbPTM
PDK1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDK1_YEAST
UniProt AC P40530
Protein Name [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
Gene Name PKP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 394
Subcellular Localization Mitochondrion matrix .
Protein Description Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism. Also involved in telomere maintenance..
Protein Sequence MWKIMRSWKCGGMRWAHRQRPSHELLSQLSFDQHYKIRSNIELLIQDYASKPIAPLNYEYFLQYRPPLTKKEEYMLTIKTINLLLSLTCKRLNAIQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYELHNPPKIQAKFTELLDDHEDAIVVLAKGLQEIQSCYPKFQISQFLNFHLKERITMKLLVTHYLSLMAQNKGDTNKRMIGILHRDLPIAQLIKHVSDYVNDICFVKFNTQRTPVLIHPPSQDITFTCIPPILEYIMTEVFKNAFEAQIALGKEHMPIEINLLKPDDDELYLRIRDHGGGITPEVEALMFNYSYSTHTQQSADSESTDLPGEQINNVSGMGFGLPMCKTYLELFGGKIDVQSLLGWGTDVYIKLKGPSKTALLSKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74PhosphorylationPLTKKEEYMLTIKTI
CCCCCCEEEHHHHHH		27017623
77PhosphorylationKKEEYMLTIKTINLL
CCCEEEHHHHHHHHH		27017623
148PhosphorylationFTELLDDHEDAIVVL
HHHHHCCHHHHHHHH		-
388PhosphorylationKLKGPSKTALLSKK-
EEECCCCCCCCCCC-		28889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDK1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDK1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDK1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDK2_YEASTPKP2physical
20489023
SA185_YEASTSAP185physical
20489023
BUB1_YEASTBUB1genetic
21127252
DCC1_YEASTDCC1genetic
21127252
SKN7_YEASTSKN7genetic
21127252
MET32_YEASTMET32genetic
21127252
PDK2_YEASTPKP2physical
18180296
PDP2_YEASTPTC6genetic
23704987
GPR1_YEASTGPR1genetic
27708008
UME6_YEASTUME6genetic
27708008
BLM10_YEASTBLM10genetic
27708008
IES1_YEASTIES1genetic
27708008
MST27_YEASTMST27genetic
27708008
YGK1_YEASTYGL101Wgenetic
27708008
SNT2_YEASTSNT2genetic
27708008
ARO8_YEASTARO8genetic
27708008
PFD3_YEASTPAC10genetic
27708008
SLX9_YEASTSLX9genetic
27708008
DBF2_YEASTDBF2genetic
27708008
MED20_YEASTSRB2genetic
27708008
SOL3_YEASTSOL3genetic
27708008
ELM1_YEASTELM1genetic
27708008
DCOR_YEASTSPE1genetic
27708008
TM184_YEASTYKR051Wgenetic
27708008
ATG38_YEASTATG38genetic
27708008
FAP1_YEASTFAP1genetic
27708008
PEX15_YEASTPEX15genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDK1_YEAST

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Related Literatures of Post-Translational Modification

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