dbPTM

FAP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FAP1_YEAST
UniProt AC	P53971
Protein Name	FKBP12-associated protein 1
Gene Name	FAP1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	965
Subcellular Localization	Cytoplasm . Nucleus . Translocates to the nucleus in response to rapamycin.
Protein Description	May play a role in transcription regulation..
Protein Sequence	MTEHESLGLEQNQDGGDTYRHHNLSDGCISSVEDANEQPSSYEEESDDDMQYYERAIQEISSGDSYVCMICTVEMDYTCQMFACKRCYRVFDYGCIREWALKSTEKTVDRIWKCPNCYYVSKRVPVKNRPTCWCGKVVNPDPNPLDPNSCGQTCNASTCMHGCSKICHLGPHPECTRMVEIMCHCGKHSKSIFCYQSKVMKKNFNCQEVCGLPLSCSIHTCKKKCHPGLCGPCPEMIISKDSPKKQIKCYCGNHTRANIKCSETKFPKSGKSSKDENGNRWIGVFACADNRVVDYSCRKHSFIESCISPPTINGEKACPFLPSSLKTCPCGRTALEELTKPRKHCDDPIPTCDSRCGKPLKCGKHSCPFTCHDKACMEPCLQIDSVKCACEQSTFSVPCGFQGRPRCNIKCESLMSCRRHRCTDRCCSGRPSAIRRKKNLFRTQDLLDESLVEAKHICLKPCNLTLSCGIHKCQRKCHPGKCPPCLESDSNDLVCPCGNTVVPAPVRCGTKLPTCNHPCIKVVRGESTCGHKPMPHTCHSLDVSCPPCTETVFKPCKCGKKTKVRTVCFQTDVSCGIKCGIPLSYCYHTCQKTCHLPGNCQKVCKQTCGQKRLNCNHECPKPCHGKTECPDLPCATLVKIYCKCGRIKKSVTCGAKSDRVSVTESSVLDCNEECEALKRLKELKEAFGIKEETNNFTSNELDALKKLVSVATTFEELQLPFTEAALSVYSKQERWCSQIEAILNKLMDDKTRSSLHFKPMRPPQRHFIRELAKAYGLYSESQDREPMRSVFIKKEDNGASNKPVLSLAEAYPLYESFKQLQKERKAQEFQARTTAKLINFEVQDTEPKVEVAKKNGFLVQNLVAGNTAEDLRRFFEPHLKHTLVVNPQYLILDDGKTALVYPENYETASVNTERDMELLVGHFDFMAKEAFLADSISLCSTEEELERRLDTPVIQEDSPVMDNNT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MTEHESLGLEQNQ --CCHHHCCCCCCCC	29.64	30377154
242	Phosphorylation	EMIISKDSPKKQIKC CCEEECCCCCCEEEE	42.21	21440633
566	Phosphorylation	GKKTKVRTVCFQTDV CCCEEEEEEEEECCC	25.31	25704821
729	Phosphorylation	TEAALSVYSKQERWC HHHHHHHHCHHHHHH	13.53	29650682
951	Phosphorylation	ELERRLDTPVIQEDS HHHHHCCCCCCCCCC	24.85	22369663
958	Phosphorylation	TPVIQEDSPVMDNNT CCCCCCCCCCCCCCC	20.74	22369663
965	Phosphorylation	SPVMDNNT------- CCCCCCCC-------	46.36	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FAP1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FAP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FAP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FKBP_YEAST	FPR1	physical	11805837
MRE11_YEAST	MRE11	physical	10688190
SHE2_YEAST	SHE2	physical	10688190
FKBP_YEAST	FPR1	physical	10998178
FAP1_YEAST	FAP1	physical	11967834
FKBP_YEAST	FPR1	genetic	10998178
FBRL_YEAST	NOP1	physical	16554755
MLC1_YEAST	MLC1	physical	16554755
MYO2_YEAST	MYO2	physical	16554755
IMDH3_YEAST	IMD3	physical	16429126
RL4A_YEAST	RPL4A	physical	16429126
RL5_YEAST	RPL5	physical	16429126
RL7A_YEAST	RPL7A	physical	16429126
RLA0_YEAST	RPP0	physical	16429126
RSSA1_YEAST	RPS0A	physical	16429126
YIQ1_YEAST	YIL161W	physical	16429126
SSB1_YEAST	SSB1	physical	19536198
PEX32_YEAST	PEX32	genetic	20093466
DCC1_YEAST	DCC1	genetic	20093466
FADH_YEAST	SFA1	genetic	20093466
SSD1_YEAST	SSD1	genetic	20093466
PALF_YEAST	RIM8	genetic	20093466
DPH5_YEAST	DPH5	genetic	20093466
TPS2_YEAST	TPS2	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
SNX4_YEAST	SNX4	genetic	27708008
SDHX_YEAST	YJL045W	genetic	27708008
BCA2_YEAST	BAT2	genetic	27708008
ATG10_YEAST	ATG10	genetic	27708008
UBR2_YEAST	UBR2	genetic	27708008
COA4_YEAST	COA4	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FAP1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-958, AND MASSSPECTROMETRY.	18407956 [Abstract]