SNT2_YEAST - dbPTM
SNT2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNT2_YEAST
UniProt AC P53127
Protein Name E3 ubiquitin-protein ligase SNT2 {ECO:0000305|PubMed:22570702}
Gene Name SNT2 {ECO:0000303|PubMed:17142463}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1403
Subcellular Localization Cytoplasm . Nucleus . Localizes to promoters of stress-response genes in response to oxidative stress.
Protein Description Transcriptional regulator that, together with ECM5, recruits histone deacetylase RPD3 to a small number of promoters of stress-response genes in response to oxidative stress. [PubMed: 23878396 Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation]
Protein Sequence MPKEEDFQLPRRREAAKNVNYNEMEIDTKLVQQIQIAEKSGAKTKGSNSQTPRNCKRTSNPASRNEKFKYQKFLHDKNTCWNFIPTLPPSFRKNSRFSNILDLDDAMIDLKKMSLFNTESVLLSANDTIYMISEPAGEPYYVGRVVNFVSKPEFSNTIHEAIKTTSVFPAKFFQVRMNWFYRPRDIQEHVNTFNPRLVYASLHQDICPISSYRGKCSIFHKDEVFDVLPNEKECIIRPNIFYFDELFDRYTLKYYKVYSTDKILNKWNSKSPFLYVLNRRFRYIYTEPKYPLENVLKKYVFHELEVNELSPADYQWDKRCQFCKEWCIQKESLSCDECGVCAHLYCMDPPLDRKPNKDVVWTCFSCLQKQQGTKDSHVRFLEEQALELDFIRSVRQKIEEISSKAIKENVGYNTENCWFQYLGIYSISHIGDALNDSMFFPYPFKPSRVGVKYQWNGCNHNVPWRRNSYISANSEEERGSTKTSELAWVLDASKITTRKLSEYIEQCKSEICPILNVRGETCNFIDVVLKNLLFTNYDTAEAFKKCKRELSRKFLKEPSFTAVEIRKFEEAVEKFGSELRPVCEYVGTQPMSMIVRFYYNWKKTERGLTVRGKLSKLSKNKRKKEIANHENDVETKYIDDSSFDTEKLSLAESSFQCMFCKTDYSPMWYRVTGGSDDEKIKIRMQTGVNEKTEISEKSPAHSKKNEKLGALCIRCARMWRRYAIKWVPPLETLRKITGTCQNSFYSAIEGIIEENNTNKFTLSPFQAHNKLLEWELVQDSELIIRQRMKVYKNPNSFVKMKRYSMTFHTQLYKMAVRSYRKNEFHPETMQRDLELFIEDNKEVRKAIPEQKPERAKNTKDEFPVNIIRQSPGTIKTSDTSRNRKCNDVFIEKASNNNIPKITNASNDLIEISIKTGGSSSGSVSVDKGFKFVKFDNKTFQRLRNSLKLVNNKLPKYNEPSTKKIKMINDIALSNPLNEPNGASYNYTVISHSKETSVALEKYHDGNKPSKMLEKDMILKHTKNKPKNPDTAWANNSARTFCSVCKEKFNDNDNYEVVCGNCGLTVHYFCYAIKLPKDMKKNTNLKTFKWLCDPCSNDLNPIISTTYQCSMCPTKDYDYDRYRSQSFKICPDALKCTSLGTWVHLVCSLFNEDIKYGNGQSMQPALNTTAVLIKHSRFTCGVCRINGGGLVKCNKCQYRYHITCAQNSSNFKLMFEKKNMSVDTTLPCIKDVKLNDTYTLRPILICDRHDISLEGNELYPLSYKPQHTLSYIEQYCRYYKCESDHSLVELRYFEQLRLRHGEMPGNSHDSAIKPKIYVLPFERTCPHCGTNKSLYWYEDIICHSCNLRSGAQELDFDSASANISNDNGLPVEITQQLMEGIEPAMFDIDISEAGTDKNTHPSSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
290PhosphorylationYIYTEPKYPLENVLK
EEECCCCCCHHHHHH		24.6219684113
468PhosphorylationNVPWRRNSYISANSE
CCCCCCCCCCCCCCC		23.2523749301
469PhosphorylationVPWRRNSYISANSEE
CCCCCCCCCCCCCCC		11.4819779198
509PhosphorylationEYIEQCKSEICPILN
HHHHHHHHHCCCCCC		39.5628889911
641PhosphorylationETKYIDDSSFDTEKL
CCEECCCCCCCHHHH		29.2022369663
642PhosphorylationTKYIDDSSFDTEKLS
CEECCCCCCCHHHHH		33.8522369663
645PhosphorylationIDDSSFDTEKLSLAE
CCCCCCCHHHHHHHH		32.7724961812
665PhosphorylationMFCKTDYSPMWYRVT
CEECCCCCCCEEEEC		15.8721551504
672PhosphorylationSPMWYRVTGGSDDEK
CCCEEEECCCCCCHH		27.1628889911
675PhosphorylationWYRVTGGSDDEKIKI
EEEECCCCCCHHEEE		43.1421551504
695PhosphorylationVNEKTEISEKSPAHS
CCCCCCCCCCCCCCC		32.5128889911
698PhosphorylationKTEISEKSPAHSKKN
CCCCCCCCCCCCCCC		24.2223749301
702PhosphorylationSEKSPAHSKKNEKLG
CCCCCCCCCCCHHHH		47.6428889911
870PhosphorylationPVNIIRQSPGTIKTS
CHHEEECCCCCEECC		18.5628889911
876PhosphorylationQSPGTIKTSDTSRNR
CCCCCEECCCCCCCC		28.1627017623
877PhosphorylationSPGTIKTSDTSRNRK
CCCCEECCCCCCCCE		33.6127017623
879PhosphorylationGTIKTSDTSRNRKCN
CCEECCCCCCCCEEC		29.3827017623
996PhosphorylationISHSKETSVALEKYH
EECCCCCEEEHHHHC		13.3928889911
1267PhosphorylationLSYKPQHTLSYIEQY
CCCCCHHHHHHHHHH		16.5025704821
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNT2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNT2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNT2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YL413_YEASTINA1physical
11805837
SSB1_YEASTSSB1physical
19536198
H3_YEASTHHT1physical
17142463
YPK3_YEASTYPK3genetic
21127252
KCS1_YEASTKCS1genetic
21127252
UME6_YEASTUME6genetic
21127252
MET32_YEASTMET32genetic
21127252
RAD53_YEASTRAD53physical
22570702
UBC4_YEASTUBC4physical
22570702
ECM5_YEASTECM5physical
23878396
RPD3_YEASTRPD3physical
23878396
RS21B_YEASTRPS21Bphysical
23878396
RLA4_YEASTRPP2Bphysical
23878396
RL19A_YEASTRPL19Bphysical
23878396
RL19B_YEASTRPL19Bphysical
23878396
RS6A_YEASTRPS6Bphysical
23878396
RS6B_YEASTRPS6Bphysical
23878396
RLA2_YEASTRPP2Aphysical
23878396
ECM5_YEASTECM5genetic
23878396
MCM1_YEASTMCM1genetic
27708008
MAK5_YEASTMAK5genetic
27708008
CDC4_YEASTCDC4genetic
27708008
MOB2_YEASTMOB2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
MED14_YEASTRGR1genetic
27708008
TF2B_YEASTSUA7genetic
27708008
SLX5_YEASTSLX5genetic
29674565
POC3_YEASTIRC25genetic
29674565
FKS1_YEASTFKS1genetic
29674565
DCP2_YEASTDCP2genetic
29674565
AIM44_YEASTAIM44genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNT2_YEAST

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Related Literatures of Post-Translational Modification

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