YPK3_YEAST - dbPTM
YPK3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YPK3_YEAST
UniProt AC P38070
Protein Name Serine/threonine-protein kinase YPK3 {ECO:0000305|PubMed:20702584}
Gene Name YPK3 {ECO:0000303|PubMed:20702584}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 525
Subcellular Localization Cytoplasm .
Protein Description AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients. [PubMed: 11062466 Required for phosphorylation of ribosomal protein S6 (RPS6A/RPS6B) at 'Ser-232' and 'Ser-233']
Protein Sequence MIFSLDEELHRVSLDDKKNDIKVDYSSAIYNDINHEQGSSITYEESINHLSVHSNAIPLNGMSPAHRMRRRSSAYSKFPILTPPNTRRFSITGSDAMRTNTNRLSITPQDIISSNIGENELSRNLHDFKPVRVLGQGAYGKVLLVKDVNTSKLYAMKQLRKAEILISQTATDSKREDEDKNDGNNNDNDDGLSKRLERTFAERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLKEHGTLDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSANDSAVDEEDPENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTGSNHKVIINKIQQNKQGPKIPFYLSEGMKDILNALLKKETAKRWNVDKYWAKTGANNKPTKSKKKKSGAARTSLFTEHFIFRKIDWKLLESGQLQKTTLGPIVPVITDLELAENFDTEFTSMSYEETYTDSKPININSVSKSPDMFKGFSYKASGSYLEKYF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MIFSLDEELHR
----CCCCCCHHHHC		24.8030377154
13PhosphorylationDEELHRVSLDDKKND
CHHHHCCCCCCCCCC		26.4930377154
72PhosphorylationAHRMRRRSSAYSKFP
HHHHHHCCCCCCCCC		19.9423749301
73PhosphorylationHRMRRRSSAYSKFPI
HHHHHCCCCCCCCCC		29.4325752575
82PhosphorylationYSKFPILTPPNTRRF
CCCCCCCCCCCCCCE		37.1022369663
86PhosphorylationPILTPPNTRRFSITG
CCCCCCCCCCEEEEC		29.0622369663
90PhosphorylationPPNTRRFSITGSDAM
CCCCCCEEEECCHHH		19.8922369663
92PhosphorylationNTRRFSITGSDAMRT
CCCCEEEECCHHHCC		29.4522369663
94PhosphorylationRRFSITGSDAMRTNT
CCEEEECCHHHCCCC		17.3422369663
99PhosphorylationTGSDAMRTNTNRLSI
ECCHHHCCCCCCCCC		33.0519779198
101PhosphorylationSDAMRTNTNRLSITP
CHHHCCCCCCCCCCH		22.5419779198
105PhosphorylationRTNTNRLSITPQDII
CCCCCCCCCCHHHHH		22.6022369663
107PhosphorylationNTNRLSITPQDIISS
CCCCCCCCHHHHHHC		16.1222369663
113PhosphorylationITPQDIISSNIGENE
CCHHHHHHCCCCCCH		20.0519779198
114PhosphorylationTPQDIISSNIGENEL
CHHHHHHCCCCCCHH		23.2729688323
122PhosphorylationNIGENELSRNLHDFK
CCCCCHHHHCCCCCC		16.9729688323
146AcetylationYGKVLLVKDVNTSKL
CCEEEEEECCCHHHH		56.8024489116
154PhosphorylationDVNTSKLYAMKQLRK
CCCHHHHHHHHHHHH		14.3719779198
167PhosphorylationRKAEILISQTATDSK
HHHEEEEEECCCCCC		20.3124909858
320PhosphorylationPENVNALYSIIGTPE
CCHHHHHHHHHCCHH		8.7321440633
321PhosphorylationENVNALYSIIGTPEY
CHHHHHHHHHCCHHH		14.4721440633
411AcetylationAKRWNVDKYWAKTGA
HHHCCHHHHHHHCCC		38.1124489116
490PhosphorylationTSMSYEETYTDSKPI
CCCCEEEECCCCCCC		21.56-
501PhosphorylationSKPININSVSKSPDM
CCCCCCCCCCCCCCC		24.7821551504
503PhosphorylationPININSVSKSPDMFK
CCCCCCCCCCCCCCC		27.5127717283
505PhosphorylationNINSVSKSPDMFKGF
CCCCCCCCCCCCCCC		20.7321551504
513PhosphorylationPDMFKGFSYKASGSY
CCCCCCCEEECCCCH		34.1028152593
517PhosphorylationKGFSYKASGSYLEKY
CCCEEECCCCHHHHC		24.9122890988
519PhosphorylationFSYKASGSYLEKYF-
CEEECCCCHHHHCC-		24.8521551504
520PhosphorylationSYKASGSYLEKYF--
EEECCCCHHHHCC--		23.5422890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
321SPhosphorylationKinasePKH1Q03407
Uniprot
321SPhosphorylationKinasePKH2Q12236
Uniprot
490TPhosphorylationKinaseTORC1-Uniprot
513SPhosphorylationKinaseTORC1-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YPK3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YPK3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPN10_YEASTRPN10genetic
19269370
ELP3_YEASTELP3genetic
19269370
LCF2_YEASTFAA2physical
20489023
C1TM_YEASTMIS1physical
20489023
NOP12_YEASTNOP12physical
20489023
YCQ6_YEASTYCR016Wphysical
20489023
BUD16_YEASTBUD16physical
21460040
EAF6_YEASTEAF6physical
21460040
RL4A_YEASTRPL4Aphysical
21460040
TR112_YEASTTRM112physical
21460040
HIR1_YEASTHIR1genetic
21127252
MOG1_YEASTMOG1genetic
27708008
FAL1_YEASTFAL1genetic
27708008
TAF12_YEASTTAF12genetic
27708008
DNA2_YEASTDNA2genetic
27708008
SGF29_YEASTSGF29genetic
27708008
MGR1_YEASTMGR1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
SLX8_YEASTSLX8genetic
27708008
TFS2_YEASTDST1genetic
27708008
ELP2_YEASTELP2genetic
27708008
YOR1_YEASTYOR1genetic
27708008
MED20_YEASTSRB2genetic
27708008
YJ24_YEASTKCH1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
IXR1_YEASTIXR1genetic
27708008
KTI12_YEASTKTI12genetic
27708008
SAC1_YEASTSAC1genetic
27708008
ERG3_YEASTERG3genetic
27708008
SIC1_YEASTSIC1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
ELP1_YEASTIKI3genetic
27708008
PHO84_YEASTPHO84genetic
27708008
RSF1_YEASTRSF1genetic
27708008
PALI_YEASTRIM9genetic
27708008
SCS7_YEASTSCS7genetic
27708008
CTU2_YEASTNCS2genetic
27708008
SFL1_YEASTSFL1genetic
27708008
ELP4_YEASTELP4genetic
27708008
TOR1_YEASTTOR1physical
26582391
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YPK3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82; SER-90; SER-105 ANDTHR-107, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82; SER-90; THR-107 ANDSER-519, AND MASS SPECTROMETRY.

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