SAS2_YEAST - dbPTM
SAS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAS2_YEAST
UniProt AC P40963
Protein Name Histone acetyltransferase SAS2
Gene Name SAS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 338
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Histone acetyltransferase (HAT) subunit of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3. The SAS complex is however unable to acetylate nucleosomal histones. The complex is involved in transcriptional silencing at telomeres and at HML locus. Also involved in rDNA silencing and G0 control..
Protein Sequence MARSLSQSLTATTQKLKGKKNGGKGKNKPSAKIKKTQKEMLYGILNERNIRQIQFGLNKKFSTWYGSAVYFDPETKRLGCSETKGQLSSVSNSQYWLDTLFVCEYCFKYTDDQTRFVGHVASCPFQYRVPGKIKYKSPEYTIRRVKGSKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIVYETGSTKPMGFFSKDLVSYQQNNLACILIFPPYQRRGLGLLLIEFSYKLSQLEGVISGPEVPLSPFGLIGYLKYWSQILCWHLIEGDLAHYDKVTLEDLSIVTGMRVNDVILTLKHLNCIGENNQIYLQSLNSWLKLHGTKRNWFKLKDEYLLIDD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MARSLSQSLTA
----CCCCHHHHHHH		23.8819795423
6Phosphorylation--MARSLSQSLTATT
--CCCCHHHHHHHHH		20.9725752575
8PhosphorylationMARSLSQSLTATTQK
CCCCHHHHHHHHHHH		25.0619823750
10PhosphorylationRSLSQSLTATTQKLK
CCHHHHHHHHHHHHC		27.4919823750
12PhosphorylationLSQSLTATTQKLKGK
HHHHHHHHHHHHCCC		25.2319823750
13PhosphorylationSQSLTATTQKLKGKK
HHHHHHHHHHHCCCC		22.6519823750
15AcetylationSLTATTQKLKGKKNG
HHHHHHHHHCCCCCC		50.5024489116
17AcetylationTATTQKLKGKKNGGK
HHHHHHHCCCCCCCC		75.5922865919
32AcetylationGKNKPSAKIKKTQKE
CCCCCCHHCCHHHHH		60.4425381059
35AcetylationKPSAKIKKTQKEMLY
CCCHHCCHHHHHHHH		60.7124489116
36PhosphorylationPSAKIKKTQKEMLYG
CCHHCCHHHHHHHHH		39.6127017623
38AcetylationAKIKKTQKEMLYGIL
HHCCHHHHHHHHHHH		50.7724489116
62PhosphorylationFGLNKKFSTWYGSAV
ECCCCCCCCCCCEEE		27.2330377154
63PhosphorylationGLNKKFSTWYGSAVY
CCCCCCCCCCCEEEE		26.3230377154
65PhosphorylationNKKFSTWYGSAVYFD
CCCCCCCCCEEEEEC		10.9928889911
67PhosphorylationKFSTWYGSAVYFDPE
CCCCCCCEEEEECCC		10.0030377154
70PhosphorylationTWYGSAVYFDPETKR
CCCCEEEEECCCCCC		11.2828889911
168AcetylationTKLYLDNKSMYFKVD
HHHHCCCCCEEEEEC		35.9422020126
277PhosphorylationLAHYDKVTLEDLSIV
CCCCCCCCHHHHHHH		30.1228889911
282PhosphorylationKVTLEDLSIVTGMRV
CCCHHHHHHHCCCCH		27.6028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
168KAcetylation

22020126
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ASF1_YEASTASF1physical
11731480
SAS5_YEASTSAS5physical
11731480
SAS4_YEASTSAS4physical
11731479
SAS5_YEASTSAS5physical
11731479
SAS4_YEASTSAS4physical
12626510
SAS5_YEASTSAS5physical
12626510
RLF2_YEASTRLF2physical
11731480
SAS2_YEASTSAS2physical
11731480
SAS4_YEASTSAS4physical
11731480
SAS5_YEASTSAS5physical
15659401
SAS4_YEASTSAS4physical
15659401
TAF10_YEASTTAF10physical
15659401
TAF6_YEASTTAF6physical
15659401
RL10_YEASTRPL10physical
15659401
PLB1_YEASTPLB1physical
15659401
DSF2_YEASTDSF2physical
15659401
BMH2_YEASTBMH2physical
15659401
MKT1_YEASTMKT1physical
15659401
RUVB1_YEASTRVB1physical
15659401
GAS5_YEASTGAS5physical
15659401
LSB3_YEASTLSB3physical
15659401
HSP60_YEASTHSP60physical
15659401
PMA1_YEASTPMA1physical
15659401
RLF2_YEASTRLF2genetic
11731480
HIR1_YEASTHIR1genetic
11731480
SIR1_YEASTSIR1genetic
11731480
SIR2_YEASTSIR2genetic
11731480
ASF1_YEASTASF1genetic
11731479
SIR1_YEASTSIR1genetic
15891116
SAS4_YEASTSAS4physical
16554755
H4_YEASTHHF1physical
12379856
SAS4_YEASTSAS4physical
15788653
IMB3_YEASTPSE1physical
15788653
IMB4_YEASTKAP123physical
15788653
EAF1_YEASTEAF1genetic
17314980
DEP1_YEASTDEP1genetic
17314980
SIR1_YEASTSIR1genetic
17314980
PFD1_YEASTPFD1genetic
17314980
TAF12_YEASTTAF12genetic
17314980
PFD6_YEASTYKE2genetic
17314980
NUP84_YEASTNUP84genetic
17314980
CTF8_YEASTCTF8genetic
17314980
YML9_YEASTYML119Wgenetic
17314980
VID22_YEASTVID22genetic
17314980
YBI6_YEASTYBL086Cgenetic
17314980
EAF1_YEASTEAF1genetic
18676811
EPL1_YEASTEPL1genetic
18676811
ESA1_YEASTESA1genetic
18676811
SIR1_YEASTSIR1genetic
18676811
SPT20_YEASTSPT20genetic
18676811
SPT7_YEASTSPT7genetic
18676811
YNG2_YEASTYNG2genetic
18676811
ORC2_YEASTORC2genetic
18682530
ORC5_YEASTORC5genetic
18682530
GCN5_YEASTGCN5genetic
19638198
DEP1_YEASTDEP1genetic
20093466
AK_YEASTHOM3genetic
20093466
RTF1_YEASTRTF1genetic
20093466
YGI1_YEASTYGL081Wgenetic
20093466
TPM2_YEASTTPM2genetic
20093466
SDS3_YEASTSDS3genetic
20093466
RL8B_YEASTRPL8Bgenetic
20093466
SAP30_YEASTSAP30genetic
20093466
BRE5_YEASTBRE5genetic
20093466
SIN3_YEASTSIN3genetic
20093466
LGE1_YEASTLGE1genetic
20093466
YPR09_YEASTYPR109Wgenetic
20093466
SUE1_YEASTSUE1genetic
20093466
RPD3_YEASTRPD3genetic
20133733
SIR2_YEASTSIR2genetic
20133733
SIR3_YEASTSIR3genetic
20133733
SIR4_YEASTSIR4genetic
20133733
H4_YEASTHHF1genetic
20133733
H3_YEASTHHT1genetic
20133733
SCM3_YEASTSCM3genetic
21652526
RPD3_YEASTRPD3genetic
21896656
SIR3_YEASTSIR3genetic
21896656
SIR2_YEASTSIR2genetic
21902802
MCES_YEASTABD1genetic
27708008
SEC7_YEASTSEC7genetic
27708008
COPD_YEASTRET2genetic
27708008
ARP3_YEASTARP3genetic
27708008
CWC16_YEASTYJU2genetic
27708008
SGF29_YEASTSGF29genetic
27708008
ORC2_YEASTORC2genetic
27708008
MCM7_YEASTMCM7genetic
27708008
TFB1_YEASTTFB1genetic
27708008
PRI2_YEASTPRI2genetic
27708008
RRN3_YEASTRRN3genetic
27708008
HRP1_YEASTHRP1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
RIF1_YEASTRIF1genetic
27708008
STE50_YEASTSTE50genetic
27708008
YCZ0_YEASTYCR100Cgenetic
27708008
GPR1_YEASTGPR1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
PP2A1_YEASTPPH21genetic
27708008
YD157_YEASTYDL157Cgenetic
27708008
UME6_YEASTUME6genetic
27708008
RTF1_YEASTRTF1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
DAL81_YEASTDAL81genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
ROM2_YEASTROM2genetic
27708008
SIN3_YEASTSIN3genetic
27708008
LGE1_YEASTLGE1genetic
27708008
ELP3_YEASTELP3genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
FUMH_YEASTFUM1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASSSPECTROMETRY.

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