DSF2_YEAST - dbPTM
DSF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DSF2_YEAST
UniProt AC P38213
Protein Name Protein DSF2
Gene Name DSF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 736
Subcellular Localization
Protein Description
Protein Sequence MNQNLKNTSWADRIGSDDQERKANSSEVSQSPPPNNSFESSMDSQFSYAHSNKSSISFESIQTTERLLDKLDLSLEDELILQEALLEEENASRNSQLSQTSGPTLCMPASEFPSLRYRTNPSPTYIQARDRSLIIDNLKEKDSTLRGKYSSGKVERHLPVKSRYSYIVEEDYDSETFSGMKPQMNRNEKDYKYPNLENGNRSTNSPNPFNFEKYRIENTRLHHLYPTLISDNNTSVDNNANSKNNRTTSNNINTSTKTDRISEKQSCPNEFTTTQKSNCLYRNGSSTSTNTSFSEVGQLSKPKTQSSFESESSSFSKLKLTKSDTTPIKPSPKRSNSSTSTITKTNTMTNDISLPPTPPYKAHKKKTSLNSLKKLFKSPRTRAKNKKDLESEGSSPIRSATNSLDFSGENIQLPSTSSTINNSSPHLARYIFPPNPVFHFKTASTPQSSTDKKKNSKARPNRTHLRTFSDFHTTEKDSKIGELSALTEQSNKPYHPKVRRRTLSLDGMLPNNSTQCMDSFSHKKEGSNATSKCGKLKFHPEPYDNDESSHIGQAITMRHQGKLEESAQRLKKACACGNKTAFLLYGLALRHGCGVDKNLKLSLGYLMAATDIKSFAAEVLDLDINPLNFASMDDIPDIAPEPTAPALYECGMAYLKGLGMDHPDERKGLKFLEKAALLGHVDSMCLSGTIWSKTSNVKKRDLARAAAWFRIADKKGANLLGSDWIYKEKYMKQGPK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationNQNLKNTSWADRIGS
CCCCCCCCHHHHCCC		29.6621440633
16PhosphorylationSWADRIGSDDQERKA
CHHHHCCCHHHHHHH		35.3321440633
54PhosphorylationSYAHSNKSSISFESI
HHCCCCCCCCCHHHH		36.8425521595
55PhosphorylationYAHSNKSSISFESIQ
HCCCCCCCCCHHHHH		24.7021551504
57PhosphorylationHSNKSSISFESIQTT
CCCCCCCCHHHHHHH		25.5522369663
60PhosphorylationKSSISFESIQTTERL
CCCCCHHHHHHHHHH		20.2722369663
63PhosphorylationISFESIQTTERLLDK
CCHHHHHHHHHHHHH		29.0224961812
64PhosphorylationSFESIQTTERLLDKL
CHHHHHHHHHHHHHC		11.6124961812
122PhosphorylationLRYRTNPSPTYIQAR
CCCCCCCCCCEEEEC		31.7625752575
132PhosphorylationYIQARDRSLIIDNLK
EEEECCCEEEECCCC		28.3630377154
202PhosphorylationNLENGNRSTNSPNPF
CCCCCCCCCCCCCCC		35.6229688323
203PhosphorylationLENGNRSTNSPNPFN
CCCCCCCCCCCCCCC		36.1629734811
205PhosphorylationNGNRSTNSPNPFNFE
CCCCCCCCCCCCCCC		26.5829688323
247PhosphorylationANSKNNRTTSNNINT
CCCCCCCCCCCCCCC		36.3821440633
248PhosphorylationNSKNNRTTSNNINTS
CCCCCCCCCCCCCCC		26.6421440633
249PhosphorylationSKNNRTTSNNINTST
CCCCCCCCCCCCCCC		27.5425752575
256PhosphorylationSNNINTSTKTDRISE
CCCCCCCCCCCCCCC		35.6121440633
257UbiquitinationNNINTSTKTDRISEK
CCCCCCCCCCCCCCC		48.4723749301
264UbiquitinationKTDRISEKQSCPNEF
CCCCCCCCCCCCCCC		40.4923749301
266PhosphorylationDRISEKQSCPNEFTT
CCCCCCCCCCCCCCC		42.4823749301
276UbiquitinationNEFTTTQKSNCLYRN
CCCCCCCCCCCEEEC		41.3623749301
285PhosphorylationNCLYRNGSSTSTNTS
CCEEECCCCCCCCCC		33.7122369663
286PhosphorylationCLYRNGSSTSTNTSF
CEEECCCCCCCCCCH		27.9822369663
287PhosphorylationLYRNGSSTSTNTSFS
EEECCCCCCCCCCHH		41.0721440633
288PhosphorylationYRNGSSTSTNTSFSE
EECCCCCCCCCCHHH		22.9322369663
289PhosphorylationRNGSSTSTNTSFSEV
ECCCCCCCCCCHHHC		42.4721551504
291PhosphorylationGSSTSTNTSFSEVGQ
CCCCCCCCCHHHCCC		31.1022369663
292PhosphorylationSSTSTNTSFSEVGQL
CCCCCCCCHHHCCCC		28.9223749301
294PhosphorylationTSTNTSFSEVGQLSK
CCCCCCHHHCCCCCC		31.0123749301
300PhosphorylationFSEVGQLSKPKTQSS
HHHCCCCCCCCCHHC		38.7423749301
304PhosphorylationGQLSKPKTQSSFESE
CCCCCCCCHHCCCCC		42.0622369663
306PhosphorylationLSKPKTQSSFESESS
CCCCCCHHCCCCCCC		42.0722369663
307PhosphorylationSKPKTQSSFESESSS
CCCCCHHCCCCCCCC		24.1822369663
310PhosphorylationKTQSSFESESSSFSK
CCHHCCCCCCCCCCC		40.5423749301
312PhosphorylationQSSFESESSSFSKLK
HHCCCCCCCCCCCEE		40.3322369663
313PhosphorylationSSFESESSSFSKLKL
HCCCCCCCCCCCEEC		31.2022369663
314PhosphorylationSFESESSSFSKLKLT
CCCCCCCCCCCEECC		42.7022369663
316PhosphorylationESESSSFSKLKLTKS
CCCCCCCCCEECCCC		38.7422369663
321PhosphorylationSFSKLKLTKSDTTPI
CCCCEECCCCCCCCC		27.2421551504
323PhosphorylationSKLKLTKSDTTPIKP
CCEECCCCCCCCCCC		34.6528889911
325PhosphorylationLKLTKSDTTPIKPSP
EECCCCCCCCCCCCC		41.3829650682
326PhosphorylationKLTKSDTTPIKPSPK
ECCCCCCCCCCCCCC		28.1828889911
331PhosphorylationDTTPIKPSPKRSNSS
CCCCCCCCCCCCCCC		37.7428889911
335PhosphorylationIKPSPKRSNSSTSTI
CCCCCCCCCCCCCEE		47.3819684113
337PhosphorylationPSPKRSNSSTSTITK
CCCCCCCCCCCEEEE		35.9219823750
338PhosphorylationSPKRSNSSTSTITKT
CCCCCCCCCCEEEEC		30.5423749301
339PhosphorylationPKRSNSSTSTITKTN
CCCCCCCCCEEEECC		29.7017563356
340PhosphorylationKRSNSSTSTITKTNT
CCCCCCCCEEEECCC		21.5419684113
341PhosphorylationRSNSSTSTITKTNTM
CCCCCCCEEEECCCC		32.5219823750
343PhosphorylationNSSTSTITKTNTMTN
CCCCCEEEECCCCCC		31.7230377154
345PhosphorylationSTSTITKTNTMTNDI
CCCEEEECCCCCCCC		27.5428889911
347PhosphorylationSTITKTNTMTNDISL
CEEEECCCCCCCCCC		30.5128889911
349PhosphorylationITKTNTMTNDISLPP
EEECCCCCCCCCCCC		27.9228889911
353PhosphorylationNTMTNDISLPPTPPY
CCCCCCCCCCCCCCC		37.3728889911
357PhosphorylationNDISLPPTPPYKAHK
CCCCCCCCCCCCHHC		34.6523749301
360PhosphorylationSLPPTPPYKAHKKKT
CCCCCCCCCHHCCCC		23.2428889911
367PhosphorylationYKAHKKKTSLNSLKK
CCHHCCCCCHHHHHH		47.5321440633
368PhosphorylationKAHKKKTSLNSLKKL
CHHCCCCCHHHHHHH		34.1421440633
371PhosphorylationKKKTSLNSLKKLFKS
CCCCCHHHHHHHHCC		47.0321440633
378PhosphorylationSLKKLFKSPRTRAKN
HHHHHHCCHHHHHCC		16.5721440633
391PhosphorylationKNKKDLESEGSSPIR
CCHHHHHCCCCCCCH		55.3322369663
394PhosphorylationKDLESEGSSPIRSAT
HHHHCCCCCCCHHHC		28.9622369663
395PhosphorylationDLESEGSSPIRSATN
HHHCCCCCCCHHHCC		34.8922369663
403PhosphorylationPIRSATNSLDFSGEN
CCHHHCCCCCCCCCC		25.5923749301
416PhosphorylationENIQLPSTSSTINNS
CCCCCCCCCCCCCCC		25.4230377154
417PhosphorylationNIQLPSTSSTINNSS
CCCCCCCCCCCCCCC		29.8030377154
423PhosphorylationTSSTINNSSPHLARY
CCCCCCCCCCCHHHH		40.5323749301
424PhosphorylationSSTINNSSPHLARYI
CCCCCCCCCCHHHHC		20.6125752575
444PhosphorylationVFHFKTASTPQSSTD
EEEEECCCCCCCCCC		45.9428889911
448PhosphorylationKTASTPQSSTDKKKN
ECCCCCCCCCCCCCC		36.0928889911
449PhosphorylationTASTPQSSTDKKKNS
CCCCCCCCCCCCCCC		35.0628889911
450PhosphorylationASTPQSSTDKKKNSK
CCCCCCCCCCCCCCC		58.0228889911
463PhosphorylationSKARPNRTHLRTFSD
CCCCCCCHHHCHHHH		31.7224961812
467PhosphorylationPNRTHLRTFSDFHTT
CCCHHHCHHHHCCCC		33.5728889911
469PhosphorylationRTHLRTFSDFHTTEK
CHHHCHHHHCCCCHH		38.4622369663
473PhosphorylationRTFSDFHTTEKDSKI
CHHHHCCCCHHCCCH		36.3222369663
476UbiquitinationSDFHTTEKDSKIGEL
HHCCCCHHCCCHHHH		66.2717644757
479UbiquitinationHTTEKDSKIGELSAL
CCCHHCCCHHHHHHH		65.9417644757
492AcetylationALTEQSNKPYHPKVR
HHHHCCCCCCCCCCC		52.8024489116
502PhosphorylationHPKVRRRTLSLDGML
CCCCCCCEECCCCCC		20.9119779198
504PhosphorylationKVRRRTLSLDGMLPN
CCCCCEECCCCCCCC		24.6523749301
548PhosphorylationEPYDNDESSHIGQAI
CCCCCCCCCCHHHHH		30.0424961812
549PhosphorylationPYDNDESSHIGQAIT
CCCCCCCCCHHHHHH		19.6524961812
556PhosphorylationSHIGQAITMRHQGKL
CCHHHHHHHHHCCCH		15.9224961812
579UbiquitinationKACACGNKTAFLLYG
HHHHCCCHHHHHHHH		26.8917644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DSF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DSF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DSF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RLA1_YEASTRPP1Agenetic
20093466
WDR59_YEASTMTC5genetic
20093466
AP2_YEASTCAD1genetic
20093466
VTC1_YEASTVTC1genetic
20093466
DCV1_YEASTDCV1genetic
20093466
CRR1_YEASTCRR1genetic
20093466
MSC1_YEASTMSC1genetic
20093466
IOC4_YEASTIOC4genetic
20093466
MSB4_YEASTMSB4genetic
20093466
NPT1_YEASTNPT1genetic
20093466
NHP10_YEASTNHP10genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
INO2_YEASTINO2genetic
27708008
WDR59_YEASTMTC5genetic
27708008
RV167_YEASTRVS167genetic
27708008
AP2_YEASTCAD1genetic
27708008
DCV1_YEASTDCV1genetic
27708008
THIK_YEASTPOT1genetic
27708008
PTK2_YEASTPTK2genetic
27708008
CRR1_YEASTCRR1genetic
27708008
MSC1_YEASTMSC1genetic
27708008
MSB4_YEASTMSB4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DSF2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-338 AND SER-391,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337 AND THR-339, ANDMASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57, AND MASSSPECTROMETRY.

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