IOC4_YEAST - dbPTM
IOC4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IOC4_YEAST
UniProt AC Q04213
Protein Name ISWI one complex protein 4
Gene Name IOC4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 475
Subcellular Localization Nucleus .
Protein Description Functions as component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing..
Protein Sequence MSEAIFQPTDIVLAKVKGFSAWPAMIIPNELIPDNILKTKPVSVHKGKSGSDKKANEDIDADMESEARDREQSEEEEDIEDFGESEANPEKFIIYTPVLKFRKNDTLKSTYCVKFFCDDSYIWVKPMDMKILTSEDCRKWLSGKQRKNKKLIPAYEMAMRGKNGIDIWEFVEYGSYGKPDEEEYVEEEEEENEPEKKAIRPTRSSSRQRQKRASETEKSEGGNSNKRKRVTRSTRQQAIDASEEEEEEEEEKVQEAVRKRPQRTKTKKVVVSKTKPNPKTKAKKEKPKPPKPIKYHFEDDEDWSIVGLGPQDLSIEKTMDPIAKKLSQKKNLEKHVEIKLDLEDKLAGINKLLCDVLCSAINQAVSIKDDFEIILDELQIALDTRGSRNEFITIFQSNNSLLLNFRILFNLRKRELNKWDLWDRFQDIFKHIYSYQFIPDTEDWQLEQNMEIEEMDREKPSFSEDVKEEESKVGA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSEAIFQPT
------CCCCCCCCC
35.4228889911
9PhosphorylationSEAIFQPTDIVLAKV
CCCCCCCCCEEEEEC
27.8128889911
43PhosphorylationILKTKPVSVHKGKSG
CCCCCCCEECCCCCC
27.3427017623
65PhosphorylationDIDADMESEARDREQ
CCCHHHHHHHHHHHH
29.8925521595
73PhosphorylationEARDREQSEEEEDIE
HHHHHHHHHHHHHHH
42.0722369663
95PhosphorylationNPEKFIIYTPVLKFR
CCCCEEEEEEEEEEC
10.5219823750
96PhosphorylationPEKFIIYTPVLKFRK
CCCEEEEEEEEEECC
9.1227214570
100AcetylationIIYTPVLKFRKNDTL
EEEEEEEEECCCCCC
43.2724489116
155PhosphorylationNKKLIPAYEMAMRGK
CCCCHHHHHHHHCCC
10.8227017623
231PhosphorylationSNKRKRVTRSTRQQA
CHHHHHHCHHHHHHH
23.9619823750
233PhosphorylationKRKRVTRSTRQQAID
HHHHHCHHHHHHHHH
20.6921551504
234PhosphorylationRKRVTRSTRQQAIDA
HHHHCHHHHHHHHHC
29.2519823750
242PhosphorylationRQQAIDASEEEEEEE
HHHHHHCCHHHHHHH
41.6217330950
418AcetylationLRKRELNKWDLWDRF
HCHHHHCCCCHHHHH
55.5024489116
461PhosphorylationEMDREKPSFSEDVKE
HHHHCCCCCCHHHHH
53.0928889911
463PhosphorylationDREKPSFSEDVKEEE
HHCCCCCCHHHHHHH
36.9128889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IOC4_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IOC4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IOC4_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2B2_YEASTHTB2physical
16554755
ISW1_YEASTISW1physical
16554755
HMO1_YEASTHMO1physical
16554755
IOC2_YEASTIOC2physical
16554755
AIM4_YEASTAIM4genetic
17314980
VPS64_YEASTVPS64genetic
17314980
BMH1_YEASTBMH1genetic
17314980
PLMT_YEASTOPI3genetic
17314980
RPN6_YEASTRPN6genetic
17314980
MED3_YEASTPGD1genetic
17314980
UBC8_YEASTUBC8genetic
17314980
GBP2_YEASTGBP2genetic
17314980
PAU8_YEASTPAU8genetic
20093466
PAU11_YEASTPAU8genetic
20093466
PAU9_YEASTPAU8genetic
20093466
FUN19_YEASTFUN19genetic
20093466
VPS8_YEASTVPS8genetic
20093466
SAS3_YEASTSAS3genetic
20093466
HAP3_YEASTHAP3genetic
20093466
DSF2_YEASTDSF2genetic
20093466
AGP2_YEASTAGP2genetic
20093466
YBY9_YEASTYBR139Wgenetic
20093466
ARL1_YEASTARL1genetic
20093466
HPC2_YEASTHPC2genetic
20093466
YB70_YEASTYBR220Cgenetic
20093466
RMD9L_YEASTYBR238Cgenetic
20093466
DPH7_YEASTRRT2genetic
20093466
REI1_YEASTREI1genetic
20093466
MRC1_YEASTMRC1genetic
20093466
YCE9_YEASTYCL049Cgenetic
20093466
YD186_YEASTYDL186Wgenetic
20093466
YD114_YEASTYDL114Wgenetic
20093466
MCH1_YEASTMCH1genetic
20093466
SLX5_YEASTSLX5genetic
20093466
SOK1_YEASTSOK1genetic
20093466
RRP8_YEASTRRP8genetic
20093466
RM01_YEASTMRPL1genetic
20093466
ODO2_YEASTKGD2genetic
20093466
SLX8_YEASTSLX8genetic
20093466
CHD1_YEASTCHD1genetic
20093466
MIC19_YEASTMIC19genetic
20093466
YIP4_YEASTYIP4genetic
20093466
MON1_YEASTMON1genetic
20093466
PUS2_YEASTPUS2genetic
20093466
CGR1_YEASTCGR1genetic
20093466
PCP1_YEASTPCP1genetic
20093466
PACC_YEASTRIM101genetic
20093466
DNPEP_YEASTAPE4genetic
20093466
FLX1_YEASTFLX1genetic
20093466
DPH1_YEASTDPH1genetic
20093466
EST3_YEASTEST3genetic
20093466
IF4A_YEASTTIF2genetic
20093466
3HAO_YEASTBNA1genetic
20093466
HAP4_YEASTHAP4genetic
20093466
YKH1_YEASTYKL071Wgenetic
20093466
MDM35_YEASTMDM35genetic
20093466
DBP7_YEASTDBP7genetic
20093466
TVP38_YEASTTVP38genetic
20093466
FPS1_YEASTFPS1genetic
20093466
RAX2_YEASTRAX2genetic
20093466
AVL9_YEASTAVL9genetic
20093466
SRN2_YEASTSRN2genetic
20093466
ADY4_YEASTADY4genetic
20093466
FKS1_YEASTFKS1genetic
20093466
AEP2_YEASTAEP2genetic
20093466
UBP15_YEASTUBP15genetic
20093466
RAS2_YEASTRAS2genetic
20093466
PET8_YEASTPET8genetic
20093466
HMI1_YEASTHMI1genetic
20093466
AHC1_YEASTAHC1genetic
20093466
CSK2C_YEASTCKB2genetic
20093466
SYC1_YEASTSYC1genetic
20093466
YO283_YEASTYOR283Wgenetic
20093466
MSC6_YEASTMSC6genetic
20093466
RU2A_YEASTLEA1genetic
20093466
RTC6_YEASTRTC6genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
LGE1_YEASTLGE1genetic
20093466
YP147_YEASTYPR147Cgenetic
20093466
H3_YEASTHHT1physical
22751925
CHD1_YEASTCHD1genetic
27149855
SEF1_YEASTSEF1genetic
27708008
MBA1_YEASTMBA1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
FTHC_YEASTFAU1genetic
27708008
CGR1_YEASTCGR1genetic
27708008
COXM1_YEASTCMC1genetic
27708008
BRE2_YEASTBRE2genetic
27708008
CSF1_YEASTCSF1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
NIP80_YEASTNIP100genetic
27708008
VPS8_YEASTVPS8genetic
27708008
FUN19_YEASTFUN19genetic
27708008
GEM1_YEASTGEM1genetic
27708008
PAU8_YEASTPAU8genetic
27708008
PAU11_YEASTPAU8genetic
27708008
PAU9_YEASTPAU8genetic
27708008
HAP3_YEASTHAP3genetic
27708008
SAS3_YEASTSAS3genetic
27708008
GAL7_YEASTGAL7genetic
27708008
AGP2_YEASTAGP2genetic
27708008
YBY9_YEASTYBR139Wgenetic
27708008
DPH7_YEASTRRT2genetic
27708008
ATG22_YEASTATG22genetic
27708008
IMG2_YEASTIMG2genetic
27708008
MCH1_YEASTMCH1genetic
27708008
QRI7_YEASTQRI7genetic
27708008
YD114_YEASTYDL114Wgenetic
27708008
SOK1_YEASTSOK1genetic
27708008
VMS1_YEASTVMS1genetic
27708008
RM01_YEASTMRPL1genetic
27708008
SWI5_YEASTSWI5genetic
27708008
NUM1_YEASTNUM1genetic
27708008
RAD9_YEASTRAD9genetic
27708008
RV167_YEASTRVS167genetic
27708008
CHD1_YEASTCHD1genetic
27708008
DLDH_YEASTLPD1genetic
27708008
AIM25_YEASTAIM25genetic
27708008
YKH1_YEASTYKL071Wgenetic
27708008
HAP4_YEASTHAP4genetic
27708008
DOA1_YEASTDOA1genetic
27708008
MLP1_YEASTMLP1genetic
27708008
AVL9_YEASTAVL9genetic
27708008
SWI6_YEASTSWI6genetic
27708008
ARV1_YEASTARV1genetic
27708008
ERFB_YEASTERF2genetic
27708008
TSL1_YEASTTSL1genetic
27708008
AEP2_YEASTAEP2genetic
27708008
PET8_YEASTPET8genetic
27708008
IRA2_YEASTIRA2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
OST3_YEASTOST3genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
NCA2_YEASTNCA2genetic
27708008

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IOC4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-9; SER-65; SER-73AND SER-242, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-242, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73 AND SER-242, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242, AND MASSSPECTROMETRY.

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