UBC8_YEAST - dbPTM
UBC8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBC8_YEAST
UniProt AC P28263
Protein Name Ubiquitin-conjugating enzyme E2-24 kDa
Gene Name UBC8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 218
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the covalent attachment of ubiquitin to other proteins. Capable, in vitro, to ubiquitinate histone H2A. Has a role in the negative regulation of gluconeogenesis. Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase)..
Protein Sequence MSSSKRRIETDVMKLLMSDHQVDLINDSMQEFHVKFLGPKDTPYENGVWRLHVELPDNYPYKSPSIGFVNKIFHPNIDIASGSICLDVINSTWSPLYDLINIVEWMIPGLLKEPNGSDPLNNEAATLQLRDKKLYEEKIKEYIDKYATKEKYQQMFGGDNDSDDSDSGGDLQEEDSDSDEDMDGTGVSSGDDSVDELSEDLSDIDVSDDDDYDEVANQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
62AcetylationLPDNYPYKSPSIGFV
CCCCCCCCCCCCCCC		51.9224489116
167PhosphorylationNDSDDSDSGGDLQEE
CCCCCCCCCCCCCCC		48.9428889911
176PhosphorylationGDLQEEDSDSDEDMD
CCCCCCCCCCCCCCC		42.1528889911
178PhosphorylationLQEEDSDSDEDMDGT
CCCCCCCCCCCCCCC		47.0228889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBC8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBC8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBC8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2A2_YEASTHTA2physical
16554755
VIP1_YEASTVIP1physical
16554755
RPB1_YEASTRPO21genetic
17314980
RTG3_YEASTRTG3genetic
17314980
YBQ3_YEASTYBR053Cgenetic
20093466
RS6A_YEASTRPS6Bgenetic
20093466
RS6B_YEASTRPS6Bgenetic
20093466
ODPB_YEASTPDB1genetic
20093466
UBC13_YEASTUBC13genetic
20093466
TRS85_YEASTTRS85genetic
20093466
ARO1_YEASTARO1genetic
20093466
PEX7_YEASTPEX7genetic
20093466
HMO1_YEASTHMO1genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
VAM7_YEASTVAM7genetic
20093466
XRN1_YEASTXRN1genetic
20093466
PEX21_YEASTPEX21genetic
20093466
TBP7_YEASTYTA7genetic
20093466
YOR1_YEASTYOR1genetic
20093466
NPR3_YEASTNPR3genetic
20093466
HTD2_YEASTHTD2genetic
20093466
NMD2_YEASTNMD2genetic
20093466
AIM18_YEASTAIM18genetic
20093466
SDS3_YEASTSDS3genetic
20093466
SAC1_YEASTSAC1genetic
20093466
RM49_YEASTMRP49genetic
20093466
DBP7_YEASTDBP7genetic
20093466
LIPB_YEASTLIP2genetic
20093466
CDC73_YEASTCDC73genetic
20093466
GBLP_YEASTASC1genetic
20093466
HFA1_YEASTHFA1genetic
20093466
BCH1_YEASTBCH1genetic
20093466
BUL1_YEASTBUL1genetic
20093466
ODP2_YEASTLAT1genetic
20093466
PET8_YEASTPET8genetic
20093466
TOP1_YEASTTOP1genetic
20093466
VAM3_YEASTVAM3genetic
20093466
LIPA_YEASTLIP5genetic
20093466
PALA_YEASTRIM20genetic
20093466
ELP4_YEASTELP4genetic
20093466
RAD1_YEASTRAD1genetic
20093466
UBA3_YEASTUBA3genetic
20093466
PSH1_YEASTPSH1physical
21070970
F16P_YEASTFBP1physical
20617129
UBC8_YEASTUBC8physical
1869573
UBC8_YEASTUBC8physical
14747994
DEP1_YEASTDEP1genetic
27708008
ETR1_YEASTETR1genetic
27708008
YBQ3_YEASTYBR053Cgenetic
27708008
TPS1_YEASTTPS1genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
ODPB_YEASTPDB1genetic
27708008
APE3_YEASTAPE3genetic
27708008
SNF5_YEASTSNF5genetic
27708008
TXTP_YEASTCTP1genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
TRS85_YEASTTRS85genetic
27708008
MRM2_YEASTMRM2genetic
27708008
XRN1_YEASTXRN1genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
ELP2_YEASTELP2genetic
27708008
YOR1_YEASTYOR1genetic
27708008
NPR3_YEASTNPR3genetic
27708008
HTD2_YEASTHTD2genetic
27708008
AIM18_YEASTAIM18genetic
27708008
SDS3_YEASTSDS3genetic
27708008
FMC1_YEASTFMC1genetic
27708008
CYT2_YEASTCYT2genetic
27708008
DBP7_YEASTDBP7genetic
27708008
DID2_YEASTDID2genetic
27708008
CCW12_YEASTCCW12genetic
27708008
LIPB_YEASTLIP2genetic
27708008
BUD8_YEASTBUD8genetic
27708008
MSC1_YEASTMSC1genetic
27708008
MAC1_YEASTMAC1genetic
27708008
GBLP_YEASTASC1genetic
27708008
ODP2_YEASTLAT1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
ELP4_YEASTELP4genetic
27708008
UBA3_YEASTUBA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBC8_YEAST

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Related Literatures of Post-Translational Modification

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