PEX21_YEAST - dbPTM
PEX21_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PEX21_YEAST
UniProt AC P50091
Protein Name Peroxisomal membrane protein PEX21
Gene Name PEX21
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 288
Subcellular Localization Cytoplasm . Peroxisome membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Involved in peroxisome biogenesis and the import of peroxisomal matrix proteins that contain the peroxisomal targeting sequence PTS2. Required for peroxisomal targeting of PEX7 and growth on oleate. Acts as an activator of the seryl-tRNA synthetase SES1 by increasing its binding to tRNA..
Protein Sequence MPSVCHTSPIEKIIQQGHRIQNDSLIPSKRTKLAHTELTAHYATEDSHVEKHFLHNGSNFDGIDNVRYQNQPSPLTFITPNNTVDSSDWVPQFSSMKIDDSLEFSSEYKRLYSNYESQQRLNSSRQHLPFKNCMIRKTSCTYPPQKTLRQQRQGNRDNPTDAFQFDAEFQVLEREIQKERYEPITRRDEKWFDQDQSELQRIATDIVKCCTPPPSSASSSSTLSSSVESKLSESKFIQLMRNISSGDVTLKKNADGNSASELFSSNNGELVGNRHIFVKDEIHKDILD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
244PhosphorylationIQLMRNISSGDVTLK
HHHHHHCCCCCEEEE		31.6422369663
258PhosphorylationKKNADGNSASELFSS
EECCCCCCHHHHHHC		38.4129136822
260PhosphorylationNADGNSASELFSSNN
CCCCCCHHHHHHCCC		34.3519779198
264PhosphorylationNSASELFSSNNGELV
CCHHHHHHCCCCEEE		44.7919779198
265PhosphorylationSASELFSSNNGELVG
CHHHHHHCCCCEEEE		27.2929136822
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PEX21_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PEX21_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PEX21_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PEX7_YEASTPEX7physical
9864360
PEX7_YEASTPEX7physical
11606420
PEX18_YEASTPEX18genetic
9864360
PEX7_YEASTPEX7physical
11283351
IPYR2_YEASTPPA2physical
11283351
SYSC_YEASTSES1physical
17451428
SYSC_YEASTSES1physical
18067851
PEX7_YEASTPEX7physical
23812376
THIK_YEASTPOT1physical
23812376
MOB2_YEASTMOB2genetic
27708008
PEX12_YEASTPEX12genetic
27708008
KPC1_YEASTPKC1genetic
27708008
SCC1_YEASTMCD1genetic
27708008
APC11_YEASTAPC11genetic
27708008
NSE4_YEASTNSE4genetic
27708008
NOP14_YEASTNOP14genetic
27708008
FAL1_YEASTFAL1genetic
27708008
LCB2_YEASTLCB2genetic
27708008
GNA1_YEASTGNA1genetic
27708008
ACT_YEASTACT1genetic
27708008
RPN11_YEASTRPN11genetic
27708008
SAD1_YEASTSAD1genetic
27708008
STT3_YEASTSTT3genetic
27708008
CDC12_YEASTCDC12genetic
27708008
MET30_YEASTMET30genetic
27708008
NU159_YEASTNUP159genetic
27708008
KTHY_YEASTCDC8genetic
27708008
SMC4_YEASTSMC4genetic
27708008
RU1C_YEASTYHC1genetic
27708008
TAF4_YEASTTAF4genetic
27708008
PDS5_YEASTPDS5genetic
27708008
DPOA_YEASTPOL1genetic
27708008
CH10_YEASTHSP10genetic
27708008
XRN2_YEASTRAT1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
MOT1_YEASTMOT1genetic
27708008
MED10_YEASTNUT2genetic
27708008
MDHP_YEASTMDH3genetic
27708008
VPS41_YEASTVPS41genetic
27708008
SAN1_YEASTSAN1genetic
27708008
URH1_YEASTURH1genetic
27708008
DOT1_YEASTDOT1genetic
27708008
STP1_YEASTSTP1genetic
27708008
SCS2_YEASTSCS2genetic
27708008
YE17_YEASTYER187Wgenetic
27708008
GLPK_YEASTGUT1genetic
27708008
INM1_YEASTINM1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
NAM8_YEASTNAM8genetic
27708008
AP18A_YEASTYAP1801genetic
27708008
PSMD9_YEASTNAS2genetic
27708008
EAF6_YEASTEAF6genetic
27708008
ELM1_YEASTELM1genetic
27708008
PFD6_YEASTYKE2genetic
27708008
TOP3_YEASTTOP3genetic
27708008
ROM2_YEASTROM2genetic
27708008
SAS2_YEASTSAS2genetic
27708008
PFD4_YEASTGIM3genetic
27708008
PDE2_YEASTPDE2genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
PEX7_YEASTPEX7physical
26276932
PEX13_YEASTPEX13physical
26276932
PEX14_YEASTPEX14physical
26276932
GPD1_YEASTGPD1physical
26276932
PEX18_YEASTPEX18genetic
26276932
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PEX21_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.

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