GLPK_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLPK_YEAST
• UniProt AC: P32190
• Protein Name: Glycerol kinase
• Gene Name: GUT1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 709
• Protein Sequence: MFPSLFRLVVFSKRYIFRSSQRLYTSLKQEQSRMSKIMEDLRSDYVPLIASIDVGTTSSRCILFNRWGQDVSKHQIEYSTSASKGKIGVSGLRRPSTAPARETPNAGDIKTSGKPIFSAEGYAIQETKFLKIEELDLDFHNEPTLKFPKPGWVECHPQKLLVNVVQCLASSLLSLQTINSERVANGLPPYKVICMGIANMRETTILWSRRTGKPIVNYGIVWNDTRTIKIVRDKWQNTSVDRQLQLRQKTGLPLLSTYFSCSKLRWFLDNEPLCTKAYEENDLMFGTVDTWLIYQLTKQKAFVSDVTNASRTGFMNLSTLKYDNELLEFWGIDKNLIHMPEIVSSSQYYGDFGIPDWIMEKLHDSPKTVLRDLVKRNLPIQGCLGDQSASMVGQLAYKPGAAKCTYGTGCFLLYNTGTKKLISQHGALTTLAFWFPHLQEYGGQKPELSKPHFALEGSVAVAGAVVQWLRDNLRLIDKSEDVGPIASTVPDSGGVVFVPAFSGLFAPYWDPDARATIMGMSQFTTASHIARAAVEGVCFQARAILKAMSSDAFGEGSKDRDFLEEISDVTYEKSPLSVLAVDGGMSRSNEVMQIQADILGPCVKVRRSPTAECTALGAAIAANMAFKDVNERPLWKDLHDVKKWVFYNGMEKNEQISPEAHPNLKIFRSESDDAERRKHWKYWEVAVERSKGWLKDIEGEHEQVLENFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	SKGKIGVSGLRRPST CCCCCCCCCCCCCCC	27.22	24961812
96	Phosphorylation	VSGLRRPSTAPARET CCCCCCCCCCCCCCC	35.08	20377248
97	Phosphorylation	SGLRRPSTAPARETP CCCCCCCCCCCCCCC	39.07	27214570
103	Phosphorylation	STAPARETPNAGDIK CCCCCCCCCCCCCCC	19.11	24961812
304	Phosphorylation	TKQKAFVSDVTNASR HCCCCCHHCCCCHHH	21.65	19823750
307	Phosphorylation	KAFVSDVTNASRTGF CCCHHCCCCHHHCCC	30.02	19823750
310	Phosphorylation	VSDVTNASRTGFMNL HHCCCCHHHCCCCCC	32.23	19823750
312	Phosphorylation	DVTNASRTGFMNLST CCCCHHHCCCCCCCC	32.07	19823750
318	Phosphorylation	RTGFMNLSTLKYDNE HCCCCCCCCCEECCH	27.04	19823750
319	Phosphorylation	TGFMNLSTLKYDNEL CCCCCCCCCEECCHH	30.36	19823750

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLPK_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLPK_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLPK_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RRP1_YEAST	RRP1	physical	16554755
RV167_YEAST	RVS167	physical	16554755
STT4_YEAST	STT4	physical	16554755
LSP1_YEAST	LSP1	physical	16554755
GPP2_YEAST	GPP2	physical	20489023
GPP1_YEAST	GPP1	physical	20489023
FUMH_YEAST	FUM1	genetic	21623372
DHE4_YEAST	GDH1	genetic	21876375
GUP1_YEAST	GUP1	genetic	21876375

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND MASSSPECTROMETRY.
PubMed: 17563356