DHE4_YEAST - dbPTM
DHE4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DHE4_YEAST
UniProt AC P07262
Protein Name NADP-specific glutamate dehydrogenase 1
Gene Name GDH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 454
Subcellular Localization
Protein Description
Protein Sequence MSEPEFQQAYEEVVSSLEDSTLFEQHPEYRKVLPIVSVPERIIQFRVTWENDKGEQEVAQGYRVQYNSAKGPYKGGLRFHPSVNLSILKFLGFEQIFKNSLTGLDMGGGKGGLCVDLKGRSNNEIRRICYAFMRELSRHIGQDTDVPAGDIGVGGREIGYLFGAYRSYKNSWEGVLTGKGLNWGGSLIRPEATGYGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIELGGTVVSLSDSKGCIISETGITSEQVADISSAKVNFKSLEQIVNEYSTFSENKVQYIAGARPWTHVQKVDIALPCATQNEVSGEEAKALVAQGVKFIAEGSNMGSTPEAIAVFETARSTATGPSEAVWYGPPKAANLGGVAVSGLEMAQNSQRITWTSERVDQELKRIMINCFNECIDYAKKYTKDGKVLPSLVKGANIASFIKVSDAMFDQGDVF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSEPEFQQA
------CCCHHHHHH		62.9628889911
2Acetylation------MSEPEFQQA
------CCCHHHHHH		62.9622814378
31UbiquitinationEQHPEYRKVLPIVSV
HHCHHHHHHCCEEEC		47.4224961812
53AcetylationRVTWENDKGEQEVAQ
EEEEECCCCHHHEEE		75.7624489116
53UbiquitinationRVTWENDKGEQEVAQ
EEEEECCCCHHHEEE		75.7623749301
53SuccinylationRVTWENDKGEQEVAQ
EEEEECCCCHHHEEE		75.7623954790
70UbiquitinationRVQYNSAKGPYKGGL
EEEECCCCCCCCCCC		61.3123749301
70SuccinylationRVQYNSAKGPYKGGL
EEEECCCCCCCCCCC		61.3123954790
74UbiquitinationNSAKGPYKGGLRFHP
CCCCCCCCCCCCCCC		50.0323749301
82PhosphorylationGGLRFHPSVNLSILK
CCCCCCCCCCHHHHH		18.3124961812
86PhosphorylationFHPSVNLSILKFLGF
CCCCCCHHHHHHHCH		22.2224961812
89UbiquitinationSVNLSILKFLGFEQI
CCCHHHHHHHCHHHH		36.5523749301
98UbiquitinationLGFEQIFKNSLTGLD
HCHHHHHHCCCCCEE		47.4524961812
110UbiquitinationGLDMGGGKGGLCVDL
CEECCCCCCCEEEEC		53.7524961812
118AcetylationGGLCVDLKGRSNNEI
CCEEEECCCCCHHHH		48.0624489116
118SuccinylationGGLCVDLKGRSNNEI
CCEEEECCCCCHHHH		48.0623954790
169UbiquitinationFGAYRSYKNSWEGVL
HHCHHCCCCCCEEEE		45.8317644757
171PhosphorylationAYRSYKNSWEGVLTG
CHHCCCCCCEEEEEC		23.5022369663
177PhosphorylationNSWEGVLTGKGLNWG
CCCEEEEECCCCCCC		34.1522369663
179UbiquitinationWEGVLTGKGLNWGGS
CEEEEECCCCCCCCC		55.8017644757
214PhosphorylationYATNGKESFEGKRVT
HHHCCCCCCCCCEEE		31.8927017623
218UbiquitinationGKESFEGKRVTISGS
CCCCCCCCEEEEECC		36.1817644757
218SuccinylationGKESFEGKRVTISGS
CCCCCCCCEEEEECC		36.1823954790
221PhosphorylationSFEGKRVTISGSGNV
CCCCCEEEEECCCCH		17.2922369663
223PhosphorylationEGKRVTISGSGNVAQ
CCCEEEEECCCCHHH		19.9622369663
225PhosphorylationKRVTISGSGNVAQYA
CEEEEECCCCHHHHE		22.0222369663
231PhosphorylationGSGNVAQYAALKVIE
CCCCHHHHEEEEEEE		5.5422369663
235UbiquitinationVAQYAALKVIELGGT
HHHHEEEEEEEECCE		36.1217644757
275UbiquitinationSSAKVNFKSLEQIVN
HHCCCCHHHHHHHHH		49.2624961812
288PhosphorylationVNEYSTFSENKVQYI
HHHHCCCCCCCCHHE		40.1128889911
291UbiquitinationYSTFSENKVQYIAGA
HCCCCCCCCHHEECC		27.0217644757
306AcetylationRPWTHVQKVDIALPC
CCCCEEEEEEEEEEC		40.5624489116
306UbiquitinationRPWTHVQKVDIALPC
CCCCEEEEEEEEEEC		40.5617644757
325AcetylationEVSGEEAKALVAQGV
CCCHHHHHHHHHHCC		45.6024489116
325UbiquitinationEVSGEEAKALVAQGV
CCCHHHHHHHHHHCC		45.6023749301
333UbiquitinationALVAQGVKFIAEGSN
HHHHHCCEEEECCCC		37.5715699485
359PhosphorylationETARSTATGPSEAVW
HHHHHCCCCCCCCEE		50.1128152593
371UbiquitinationAVWYGPPKAANLGGV
CEEECCCCCCCCCCE		64.3623749301
404SuccinylationERVDQELKRIMINCF
HHHHHHHHHHHHHHH		38.8423954790
404UbiquitinationERVDQELKRIMINCF
HHHHHHHHHHHHHHH		38.8423749301
419UbiquitinationNECIDYAKKYTKDGK
HHHHHHHHHHCCCCC		39.8317644757
420UbiquitinationECIDYAKKYTKDGKV
HHHHHHHHHCCCCCC		50.4017644757
422PhosphorylationIDYAKKYTKDGKVLP
HHHHHHHCCCCCCHH		31.3819779198
423UbiquitinationDYAKKYTKDGKVLPS
HHHHHHCCCCCCHHH		62.4815699485
426UbiquitinationKKYTKDGKVLPSLVK
HHHCCCCCCHHHHHC		51.2115699485
430PhosphorylationKDGKVLPSLVKGANI
CCCCCHHHHHCCCCH		41.4519795423
433UbiquitinationKVLPSLVKGANIASF
CCHHHHHCCCCHHHE		58.5623749301
439PhosphorylationVKGANIASFIKVSDA
HCCCCHHHEEEHHHH		24.5727214570
442UbiquitinationANIASFIKVSDAMFD
CCHHHEEEHHHHHCC		33.4117644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DHE4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DHE4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DHE4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LSM1_YEASTLSM1physical
10688190
DHE5_YEASTGDH3genetic
11562373
DHE2_YEASTGDH2genetic
222204
RAEP_YEASTMRS6physical
16429126
YPT52_YEASTYPT52physical
16429126
ARO1_YEASTARO1physical
16429126
TCPQ_YEASTCCT8physical
16429126
MCE1_YEASTCEG1physical
16429126
CET1_YEASTCET1physical
16429126
DHE2_YEASTGDH2genetic
19619667
DHE5_YEASTGDH3genetic
18408719
DHE5_YEASTGDH3genetic
16941010
GLT1_YEASTGLT1genetic
16941010
DHE4_YEASTGDH1physical
19343713
UBI4P_YEASTUBI4physical
20694217
HFA1_YEASTHFA1genetic
21623372
SPEE_YEASTSPE3genetic
21623372
ADH3_YEASTADH3genetic
21623372
ARGJ_YEASTARG7genetic
21623372
CBS_YEASTCYS4genetic
21623372
ATP5E_YEASTATP15genetic
21623372
THDH_YEASTILV1genetic
21623372
COQ7_YEASTCAT5genetic
21623372
ADK_YEASTADO1genetic
21623372
ETR1_YEASTETR1genetic
21623372
COQ3_YEASTCOQ3genetic
21623372
PDX3_YEASTPDX3genetic
21623372
GAT1_YEASTGAT1genetic
26419331
DHE5_YEASTGDH3genetic
26419331
GLN3_YEASTGLN3genetic
26419331
DHE5_YEASTGDH3genetic
26936955
IDHP_YEASTIDP1genetic
26936955
JHD2_YEASTJHD2genetic
26936955
GRE3_YEASTGRE3genetic
26156706
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DHE4_YEAST

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-325 AND LYS-371, AND MASSSPECTROMETRY.

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