YPT52_YEAST - dbPTM
YPT52_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YPT52_YEAST
UniProt AC P36018
Protein Name GTP-binding protein YPT52
Gene Name YPT52
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 234
Subcellular Localization Cell membrane
Lipid-anchor
Cytoplasmic side . Endoplasmic reticulum . Also found in association with endoplasmic reticulum vesicles having SED5 on their surface.
Protein Description Required for transport in the endocytic pathway and for correct sorting of the vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway..
Protein Sequence MLQFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAFLSQSITIHPNDGNETKDVVIKFEIWDTAGQERYKSLAPMYYRNANAALVVYDITQEDSLQKARNWVDELKNKVGDDDLVIYLLGNKVDLCQETPSTETSPDSNEGGDEEQKVRAISTEEAKQYAQEQGLLFREVSAKTGEGVKEIFQDIGEKLYDLKKDEILSKQNRQIGGGNNGQVDINLQRPSTNDPTSCCS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationKLVLLGDSSVGKSSI
EEEEECCCCCCCHHH		25.7322369663
13PhosphorylationLVLLGDSSVGKSSIV
EEEECCCCCCCHHHH		39.3622369663
16UbiquitinationLGDSSVGKSSIVHRF
ECCCCCCCHHHHHHH		38.5824961812
17PhosphorylationGDSSVGKSSIVHRFV
CCCCCCCHHHHHHHH		21.2630377154
18PhosphorylationDSSVGKSSIVHRFVK
CCCCCCHHHHHHHHH		31.9230377154
25AcetylationSIVHRFVKDTFDELR
HHHHHHHHHHHHHHH		48.6224489116
46PhosphorylationAFLSQSITIHPNDGN
HHHCCCEEECCCCCC		20.6228889911
101UbiquitinationTQEDSLQKARNWVDE
CCHHHHHHHHHHHHH		55.3924961812
133PhosphorylationKVDLCQETPSTETSP
CCCCCCCCCCCCCCC		9.1729136822
135PhosphorylationDLCQETPSTETSPDS
CCCCCCCCCCCCCCC		46.4220377248
136PhosphorylationLCQETPSTETSPDSN
CCCCCCCCCCCCCCC		44.4829136822
138PhosphorylationQETPSTETSPDSNEG
CCCCCCCCCCCCCCC		45.7220377248
139PhosphorylationETPSTETSPDSNEGG
CCCCCCCCCCCCCCC		22.0720377248
142PhosphorylationSTETSPDSNEGGDEE
CCCCCCCCCCCCCHH		39.9220377248
151UbiquitinationEGGDEEQKVRAISTE
CCCCHHHHHHEECHH		36.6523749301
161AcetylationAISTEEAKQYAQEQG
EECHHHHHHHHHHHC		47.3124489116
183AcetylationAKTGEGVKEIFQDIG
HCCCCCHHHHHHHHH		56.8224489116
192AcetylationIFQDIGEKLYDLKKD
HHHHHHHHHHHCCHH		47.3224489116
197AcetylationGEKLYDLKKDEILSK
HHHHHHCCHHHHHHH		56.1124489116
203PhosphorylationLKKDEILSKQNRQIG
CCHHHHHHHCCCCCC		37.5524909858
232GeranylgeranylationSTNDPTSCCS-----
CCCCCCCCCC-----		2.65-
233GeranylgeranylationTNDPTSCCS------
CCCCCCCCC------		5.61-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YPT52_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YPT52_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YPT52_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YOP1_YEASTYOP1physical
11278413
GDI1_YEASTGDI1physical
11785952
PRA1_YEASTYIP3physical
11785952
YIP1_YEASTYIP1physical
12802060
VPS21_YEASTVPS21genetic
8163546
RAEP_YEASTMRS6physical
16429126
SKP1_YEASTSKP1physical
16429126
EF3A_YEASTYEF3physical
16429126
ROY1_YEASTROY1physical
16429126
RAEP_YEASTMRS6physical
18467557
ROY1_YEASTROY1physical
18719252
RAEP_YEASTMRS6physical
18719252
VPS8_YEASTVPS8physical
20173035
ROY1_YEASTROY1physical
21389113
SKP1_YEASTSKP1physical
21389113
YPT53_YEASTYPT53genetic
21363887
GDI1_YEASTGDI1physical
22157956
YIF1_YEASTYIF1physical
22157956
YIP1_YEASTYIP1physical
22157956
YIP4_YEASTYIP4physical
22157956
YIP5_YEASTYIP5physical
22157956
YPT52_YEASTYPT52physical
22157956
YPT53_YEASTYPT53physical
22157956
YPT6_YEASTYPT6physical
22157956
YPT7_YEASTYPT7physical
22157956
VPS21_YEASTVPS21physical
22157956
GYP3_YEASTMSB3physical
22593206
SLX5_YEASTSLX5genetic
27708008
GPR1_YEASTGPR1genetic
27708008
RPA14_YEASTRPA14genetic
27708008
IZH2_YEASTIZH2genetic
27708008
VPS8_YEASTVPS8genetic
27708008
HPC2_YEASTHPC2genetic
27708008
BUD31_YEASTBUD31genetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
LSM6_YEASTLSM6genetic
27708008
CEM1_YEASTCEM1genetic
27708008
RS26B_YEASTRPS26Bgenetic
27708008
IES1_YEASTIES1genetic
27708008
ATC1_YEASTPMR1genetic
27708008
STB5_YEASTSTB5genetic
27708008
YIF5_YEASTYIL055Cgenetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
DOHH_YEASTLIA1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
BPT1_YEASTBPT1genetic
27708008
YL149_YEASTYLR149Cgenetic
27708008
LIPB_YEASTLIP2genetic
27708008
VPS38_YEASTVPS38genetic
27708008
HXT2_YEASTHXT2genetic
27708008
SOK2_YEASTSOK2genetic
27708008
OCA2_YEASTOCA2genetic
27708008
EOS1_YEASTEOS1genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
ETT1_YEASTETT1genetic
27708008
VPS21_YEASTVPS21genetic
27708008
DDP1_YEASTDDP1genetic
27708008
GET4_YEASTGET4genetic
27708008
LIPA_YEASTLIP5genetic
27708008
SSP2_YEASTSSP2genetic
27708008
MMT2_YEASTMMT2genetic
27708008
AP3M_YEASTAPM3genetic
24667230
DP13B_HUMANAPPL2physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YPT52_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-46 AND SER-135, AND MASSSPECTROMETRY.

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