YPT53_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YPT53_YEAST
• UniProt AC: P36019
• Protein Name: GTP-binding protein YPT53
• Gene Name: YPT53
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 220
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Required for transport in the endocytic pathway and for correct sorting of the vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway..
• Protein Sequence: MDKHTAAIPTLTIKVVLLGESAVGKSSIVLRFVSDDFKESKEPTIGAAFLTKRITRDGKVIKFEIWDTAGQERFAPLAPMYYRNAQAALVVFDVTNEGSFYKAQNWVEELHEKVGHDIVIALVGNKMDLLNNDDENENRAMKAPAVQNLCERENLLYFEASAKTGENIYQIFQTLGEKVPCPEQNTRQSSTHDRTITDNQRIDLESTTVESTRETGGCNC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	VSDDFKESKEPTIGA ECCCHHHCCCCCCEE	42.80	27017623
44	Phosphorylation	FKESKEPTIGAAFLT HHHCCCCCCEEEEEE	32.89	27017623
51	Phosphorylation	TIGAAFLTKRITRDG CCEEEEEEEEEECCC	16.30	27017623
161	Phosphorylation	NLLYFEASAKTGENI CEEEEEECCCCCCCH	24.09	19779198
186	Phosphorylation	VPCPEQNTRQSSTHD CCCCCCCCCCCCCCC	29.76	29136822
189	Phosphorylation	PEQNTRQSSTHDRTI CCCCCCCCCCCCCCC	33.63	29136822
190	Phosphorylation	EQNTRQSSTHDRTIT CCCCCCCCCCCCCCC	22.79	29136822
191	Phosphorylation	QNTRQSSTHDRTITD CCCCCCCCCCCCCCC	32.80	19779198
218	Geranylgeranylation	STRETGGCNC----- EHHHCCCCCC-----	5.07	-
220	Methylation	RETGGCNC------- HHCCCCCC-------	7.39	-
220	Geranylgeranylation	RETGGCNC------- HHCCCCCC-------	7.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YPT53_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YPT53_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YPT53_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS21_YEAST	VPS21	physical	11805837
VDAC1_YEAST	POR1	physical	11805837
JJJ1_YEAST	JJJ1	physical	11805837
KAPC_YEAST	TPK3	physical	11805837
IF4E_YEAST	CDC33	physical	11805837
KAPR_YEAST	BCY1	physical	11805837
RAEP_YEAST	MRS6	physical	11805837
YPT52_YEAST	YPT52	physical	11805837
KAPA_YEAST	TPK1	physical	11805837
SIW14_YEAST	SIW14	physical	10688190
GDI1_YEAST	GDI1	physical	11785952
PRA1_YEAST	YIP3	physical	11785952
YIP1_YEAST	YIP1	physical	12802060
RAEP_YEAST	MRS6	physical	18719252
VPS8_YEAST	VPS8	physical	20173035
GDI1_YEAST	GDI1	physical	22157956
YIF1_YEAST	YIF1	physical	22157956
YIP1_YEAST	YIP1	physical	22157956
YPT53_YEAST	YPT53	physical	22157956
YPT7_YEAST	YPT7	physical	22157956
YPT52_YEAST	YPT52	physical	22157956
VPS21_YEAST	VPS21	physical	22157956
VPS9_YEAST	VPS9	physical	22157956
MAL12_YEAST	MAL12	genetic	27708008
YET2_YEAST	YET2	genetic	27708008
CCZ1_YEAST	CCZ1	genetic	27708008
SWC5_YEAST	SWC5	genetic	27708008
MON1_YEAST	MON1	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
VPS13_YEAST	VPS13	genetic	27708008
TMA23_YEAST	TMA23	genetic	27708008
BUD21_YEAST	BUD21	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008
VPS21_YEAST	VPS21	genetic	27708008
COQ7_YEAST	CAT5	genetic	27708008
ELP4_YEAST	ELP4	genetic	27708008
MED1_YEAST	MED1	genetic	27708008
MDM36_YEAST	MDM36	genetic	27708008
QCR2_YEAST	QCR2	genetic	27708008
AP3M_YEAST	APM3	genetic	24667230
CAP2_HUMAN	CAP2	physical	27107014
F16A2_HUMAN	FAM160A2	physical	27107014
DP13B_HUMAN	APPL2	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.