F16A2_HUMAN - dbPTM
F16A2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID F16A2_HUMAN
UniProt AC Q8N612
Protein Name FTS and Hook-interacting protein
Gene Name FAM160A2
Organism Homo sapiens (Human).
Sequence Length 972
Subcellular Localization
Protein Description Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex)..
Protein Sequence MERMNWLSRLASRGPGHRIPQGANLQTPVMADPETCLMVFKNHWSQVVRILERQGPRAAPGGADDLSAVRNHTYQMLTLLAEDRAVPSAPTGPGPLLEFALHEDLLTRVLTWQLQWDELGDGVEERRAEQLKLFEMLVSEARQPLLRHGPVREALLTLLDACGRPVPSSPALDEGLVLLLSQLCVCVAQEPSLLEFFLQPPPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALLLLMALSAGSPTVGRYIADHSYFCPVLATGLSALYSSLPRKIEVPGDDWHCLRREDWLGVPALALFMSSLEFCNAVIQVAHPLVQKQLVDYIHNGFLVPVMGPALHKTSVEEMIASTAYLELFLRSISEPALLRTFLRFLLLHRHDTHTILDTLVARIGSNSRLCMVSLSLFRTLLNLSCEDVLLQLVLRYLVPCNHVMLSQKPAVRDVDLYGRAADKFLSLIPRCCRHHAPSPPRPEHASWARGPGSPSVDSSSVTTVPRPSTPSRLALFLRQQSLGGSESPGPAPCSPGLSASPASSPGRRPTPAEEPGELEDNYLEYLREARRGVDRCVRACRTWSAPYDGERPSPEPSPFGSRTKKRSLLPEEDRNNVGEGEEEELGRRGRAGGAGEGPGHLPPPQLNGVPGSWPEGAKKVRLVPKEGAGELLEGISEGMAGLEGFGQELRELEVALSNGGTGSESPLEPPLPLEEEEAYESFTCPPEPPGPFLSSPLRTLNQLPSQPFTGPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQPSVKSLLQVLGSVKNKIENFAASQEDFPALLSKAKKYLIARGKLDWAEGPAAGPAPRRSDPLVKSRRPSLGELLLRHAHSPTRARQAAQLVLQPGRDGAGLGLSGGSPGASTPVLLTRGGAPERQGEALRVKNAVYCAVIFPEFLKELAAISQAHAVTSPFLLETSEEGSGPLISGCGPLNP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
255PhosphorylationGRYIADHSYFCPVLA
HHHHCCCCCHHHHHH		22.0528387310
270PhosphorylationTGLSALYSSLPRKIE
HHHHHHHHHCCCCCC		26.6729262532
271PhosphorylationGLSALYSSLPRKIEV
HHHHHHHHCCCCCCC		28.9224719451
351PhosphorylationVEEMIASTAYLELFL
HHHHHHHHHHHHHHH		15.42-
381PhosphorylationLLLHRHDTHTILDTL
HHHHCCCHHHHHHHH		18.13-
387PhosphorylationDTHTILDTLVARIGS
CHHHHHHHHHHHHCC		21.49-
394PhosphorylationTLVARIGSNSRLCMV
HHHHHHCCCHHHHHH		29.30-
396PhosphorylationVARIGSNSRLCMVSL
HHHHCCCHHHHHHHH		28.47-
404PhosphorylationRLCMVSLSLFRTLLN
HHHHHHHHHHHHHHC		20.2524719451
452UbiquitinationLYGRAADKFLSLIPR
CHHHHHHHHHHHHHH		43.40-
452 (in isoform 2)Ubiquitination-43.40-
455PhosphorylationRAADKFLSLIPRCCR
HHHHHHHHHHHHHHH		27.6427251275
467PhosphorylationCCRHHAPSPPRPEHA
HHHCCCCCCCCCCCC		48.6027794612
475PhosphorylationPPRPEHASWARGPGS
CCCCCCCCCCCCCCC		24.1528152594
482PhosphorylationSWARGPGSPSVDSSS
CCCCCCCCCCCCCCC		19.6926055452
484PhosphorylationARGPGSPSVDSSSVT
CCCCCCCCCCCCCCC		40.0128348404
487PhosphorylationPGSPSVDSSSVTTVP
CCCCCCCCCCCCCCC		23.5128348404
488PhosphorylationGSPSVDSSSVTTVPR
CCCCCCCCCCCCCCC		25.1028348404
489PhosphorylationSPSVDSSSVTTVPRP
CCCCCCCCCCCCCCC		27.6928348404
491PhosphorylationSVDSSSVTTVPRPST
CCCCCCCCCCCCCCC		24.8318669648
492 (in isoform 2)Phosphorylation-26.7625850435
492PhosphorylationVDSSSVTTVPRPSTP
CCCCCCCCCCCCCCH		26.7628348404
496 (in isoform 2)Phosphorylation-36.1626425664
497PhosphorylationVTTVPRPSTPSRLAL
CCCCCCCCCHHHHHH		54.9818669648
498 (in isoform 2)Phosphorylation-28.1525850435
498PhosphorylationTTVPRPSTPSRLALF
CCCCCCCCHHHHHHH		28.1528555341
501 (in isoform 2)Phosphorylation-25.7825850435
502 (in isoform 2)Phosphorylation-5.9525850435
503 (in isoform 2)Phosphorylation-8.6525850435
505 (in isoform 2)Phosphorylation-4.3725850435
506 (in isoform 2)Phosphorylation-5.1322210691
510PhosphorylationALFLRQQSLGGSESP
HHHHHHHHCCCCCCC		22.2021082442
511 (in isoform 2)Phosphorylation-8.6122210691
512PhosphorylationFLRQQSLGGSESPGP
HHHHHHCCCCCCCCC		42.7132142685
514PhosphorylationRQQSLGGSESPGPAP
HHHHCCCCCCCCCCC		32.8628450419
514 (in isoform 2)Phosphorylation-32.8622210691
516PhosphorylationQSLGGSESPGPAPCS
HHCCCCCCCCCCCCC		36.5321082442
523PhosphorylationSPGPAPCSPGLSASP
CCCCCCCCCCCCCCC		22.4225850435
524PhosphorylationPGPAPCSPGLSASPA
CCCCCCCCCCCCCCC		55.2333259812
527PhosphorylationAPCSPGLSASPASSP
CCCCCCCCCCCCCCC		32.3925850435
529PhosphorylationCSPGLSASPASSPGR
CCCCCCCCCCCCCCC		20.0225850435
532PhosphorylationGLSASPASSPGRRPT
CCCCCCCCCCCCCCC		40.2125850435
533PhosphorylationLSASPASSPGRRPTP
CCCCCCCCCCCCCCC		33.2225850435
539PhosphorylationSSPGRRPTPAEEPGE
CCCCCCCCCCCCCCC		33.06-
571PhosphorylationRCVRACRTWSAPYDG
HHHHHHHCCCCCCCC		24.5323090842
573PhosphorylationVRACRTWSAPYDGER
HHHHHCCCCCCCCCC		20.8230576142
576PhosphorylationCRTWSAPYDGERPSP
HHCCCCCCCCCCCCC		35.9828450419
582PhosphorylationPYDGERPSPEPSPFG
CCCCCCCCCCCCCCC		48.3826055452
586PhosphorylationERPSPEPSPFGSRTK
CCCCCCCCCCCCCCC		31.0629255136
590PhosphorylationPEPSPFGSRTKKRSL
CCCCCCCCCCCCCCC		36.8429255136
596PhosphorylationGSRTKKRSLLPEEDR
CCCCCCCCCCCHHHH		43.0425159151
603MethylationSLLPEEDRNNVGEGE
CCCCHHHHCCCCCCH		39.64-
724PhosphorylationPPGPFLSSPLRTLNQ
CCCCCCCCCCCHHHC		30.0526074081
795PhosphorylationVFQPSVKSLLQVLGS
CCCHHHHHHHHHHHH		31.9628842319
802PhosphorylationSLLQVLGSVKNKIEN
HHHHHHHHHHHHHHH		26.2528842319
806UbiquitinationVLGSVKNKIENFAAS
HHHHHHHHHHHHHHC		45.7629967540
820UbiquitinationSQEDFPALLSKAKKY
CCCCHHHHHHHHHHH		5.8929967540
823UbiquitinationDFPALLSKAKKYLIA
CHHHHHHHHHHHHHH		65.2829967540
833UbiquitinationKYLIARGKLDWAEGP
HHHHHCCCCCCCCCC		37.4122817900
833 (in isoform 1)Ubiquitination-37.4121906983
837UbiquitinationARGKLDWAEGPAAGP
HCCCCCCCCCCCCCC		16.1329967540
847 (in isoform 2)Ubiquitination-53.4921906983
847UbiquitinationPAAGPAPRRSDPLVK
CCCCCCCCCCCCCHH		53.4922817900
849PhosphorylationAGPAPRRSDPLVKSR
CCCCCCCCCCCHHCC		44.8826055452
855PhosphorylationRSDPLVKSRRPSLGE
CCCCCHHCCCCCHHH		26.4923403867
859PhosphorylationLVKSRRPSLGELLLR
CHHCCCCCHHHHHHH		47.3927273156
873PhosphorylationRHAHSPTRARQAAQL
HHCCCHHHHHHHHHH		31.0232142685
894PhosphorylationDGAGLGLSGGSPGAS
CCCCCCCCCCCCCCC		39.0330266825
897PhosphorylationGLGLSGGSPGASTPV
CCCCCCCCCCCCCCE		24.5630266825
901PhosphorylationSGGSPGASTPVLLTR
CCCCCCCCCCEEEEC		38.8829255136
902PhosphorylationGGSPGASTPVLLTRG
CCCCCCCCCEEEECC		19.5130266825
907PhosphorylationASTPVLLTRGGAPER
CCCCEEEECCCCCCC		24.0929255136
908MethylationSTPVLLTRGGAPERQ
CCCEEEECCCCCCCC		41.33-
926PhosphorylationLRVKNAVYCAVIFPE
HHHCCHHHHHHHCHH		3.40-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of F16A2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of F16A2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of F16A2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
REEP6_HUMANREEP6physical
16189514
AKTIP_HUMANAKTIPphysical
18799622
HOOK1_HUMANHOOK1physical
18799622
REEP6_HUMANREEP6physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of F16A2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859 AND SER-897, ANDMASS SPECTROMETRY.

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