AKTIP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKTIP_HUMAN
• UniProt AC: Q9H8T0
• Protein Name: AKT-interacting protein
• Gene Name: AKTIP
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein .
• Protein Description: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade..
• Protein Sequence: MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAPKKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTASPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPEEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNPFWSMSTSSVR --CCCCCCCCHHHCC	11.84	24850871
8	Phosphorylation	MNPFWSMSTSSVRKR CCCCCCCCHHHCCCC	21.44	28857561
9	Phosphorylation	NPFWSMSTSSVRKRS CCCCCCCHHHCCCCC	19.17	28857561
10	Phosphorylation	PFWSMSTSSVRKRSE CCCCCCHHHCCCCCC	21.38	24850871
11	Phosphorylation	FWSMSTSSVRKRSEG CCCCCHHHCCCCCCC	26.48	28857561
16	Phosphorylation	TSSVRKRSEGEEKTL HHHCCCCCCCCCCEE	53.65	26699800
22	Phosphorylation	RSEGEEKTLTGDVKT CCCCCCCEECCCCCC	32.60	23403867
24	Phosphorylation	EGEEKTLTGDVKTSP CCCCCEECCCCCCCC	36.25	30266825
29	Phosphorylation	TLTGDVKTSPPRTAP EECCCCCCCCCCCCC	46.44	30266825
30	Phosphorylation	LTGDVKTSPPRTAPK ECCCCCCCCCCCCCH	27.47	30266825
34	Phosphorylation	VKTSPPRTAPKKQLP CCCCCCCCCCHHHCC	53.75	28152594
99	Phosphorylation	PGVYVQPSYRSALMW CCEEECCHHHHHHHH	18.98	68730471
100	Phosphorylation	GVYVQPSYRSALMWF CEEECCHHHHHHHHH	18.44	68730477
117	Phosphorylation	IFIRHGLYQDGVFKF HHHHCCCCCCCEEEE	14.78	6930601
190	Phosphorylation	RVFYKIDTASPLNPE HHHHCCCCCCCCCHH	32.29	21777610
210	Methylation	EKDIQLFKSKVVDSV HHHHHHHHHCHHCEE	58.94	-
266	Phosphorylation	PEEQHNKSVHVAGLS HHHHHCCCEEEEEEE	23.83	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKTIP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKTIP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKTIP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOOK1_HUMAN	HOOK1	physical	17353931
SYIC_HUMAN	IARS	physical	17353931
TIM50_HUMAN	TIMM50	physical	17353931
PDS5A_HUMAN	PDS5A	physical	17353931
VIGLN_HUMAN	HDLBP	physical	17353931
DCTN1_HUMAN	DCTN1	physical	17353931
AKT1_HUMAN	AKT1	physical	14749367
EXOC7_HUMAN	EXOC7	physical	16169070
PEO1_HUMAN	C10orf2	physical	16169070
ASSY_HUMAN	ASS1	physical	16169070
TF3C1_HUMAN	GTF3C1	physical	16169070
MIC60_HUMAN	IMMT	physical	16169070
DPOA2_HUMAN	POLA2	physical	16169070
RFA1_HUMAN	RPA1	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
DZIP3_HUMAN	DZIP3	physical	19549727
MARH5_HUMAN	MARCH5	physical	19549727
TRI23_HUMAN	TRIM23	physical	19549727
TRI41_HUMAN	TRIM41	physical	19549727
HOOK1_HUMAN	HOOK1	physical	18799622
HOOK2_HUMAN	HOOK2	physical	18799622
HOOK3_HUMAN	HOOK3	physical	18799622
F16A2_HUMAN	FAM160A2	physical	18799622
VPS16_HUMAN	VPS16	physical	18799622
VPS18_HUMAN	VPS18	physical	18799622
VPS41_HUMAN	VPS41	physical	18799622
HOOK1_HUMAN	HOOK1	physical	26186194
HOOK3_HUMAN	HOOK3	physical	26186194
HOOK2_HUMAN	HOOK2	physical	26186194
TRI32_HUMAN	TRIM32	physical	26186194
NAB1_HUMAN	NAB1	physical	26186194
F16A2_HUMAN	FAM160A2	physical	26186194
F16A1_HUMAN	FAM160A1	physical	26186194
TSC1_HUMAN	TSC1	physical	26186194
PGTB1_HUMAN	PGGT1B	physical	26186194
EGFR_HUMAN	EGFR	physical	25151576
TERF1_HUMAN	TERF1	physical	26110528
TERF2_HUMAN	TERF2	physical	26110528
EGFR_HUMAN	EGFR	physical	27535835
PRKDC_HUMAN	PRKDC	physical	27535835
HOOK3_HUMAN	HOOK3	physical	28514442
F16A1_HUMAN	FAM160A1	physical	28514442
F16A2_HUMAN	FAM160A2	physical	28514442
HOOK2_HUMAN	HOOK2	physical	28514442
HOOK1_HUMAN	HOOK1	physical	28514442
TSC1_HUMAN	TSC1	physical	28514442
NAB1_HUMAN	NAB1	physical	28514442
TRI32_HUMAN	TRIM32	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.