GDI1_YEAST - dbPTM
GDI1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GDI1_YEAST
UniProt AC P39958
Protein Name Rab GDP-dissociation inhibitor
Gene Name GDI1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 451
Subcellular Localization Cytoplasm .
Protein Description Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4. Plays an essential role in the yeast secretory pathway..
Protein Sequence MDQETIDTDYDVIVLGTGITECILSGLLSVDGKKVLHIDKQDHYGGEAASVTLSQLYEKFKQNPISKEERESKFGKDRDWNVDLIPKFLMANGELTNILIHTDVTRYVDFKQVSGSYVFKQGKIYKVPANEIEAISSPLMGIFEKRRMKKFLEWISSYKEDDLSTHQGLDLDKNTMDEVYYKFGLGNSTKEFIGHAMALWTNDDYLQQPARPSFERILLYCQSVARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDTPIDEVLYKKDTGKFEGVKTKLGTFKAPLVIADPTYFPEKCKSTGQRVIRAICILNHPVPNTSNADSLQIIIPQSQLGRKSDIYVAIVSDAHNVCSKGHYLAIISTIIETDKPHIELEPAFKLLGPIEEKFMGIAELFEPREDGSKDNIYLSRSYDASSHFESMTDDVKDIYFRVTGHPLVLKQRQEQEKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
54PhosphorylationEAASVTLSQLYEKFK
HHHHEEHHHHHHHHH		14.5828889911
67UbiquitinationFKQNPISKEERESKF
HHHCCCCHHHHHHHC		65.4023749301
76AcetylationERESKFGKDRDWNVD
HHHHHCCCCCCCCCC		53.3624489116
111AcetylationVTRYVDFKQVSGSYV
CCEECCCEEEECEEE		45.3824489116
1202-HydroxyisobutyrylationVSGSYVFKQGKIYKV
EECEEEEECCEEEEE		48.36-
120UbiquitinationVSGSYVFKQGKIYKV
EECEEEEECCEEEEE		48.3622817900
123UbiquitinationSYVFKQGKIYKVPAN
EEEEECCEEEEEEHH		40.1322817900
136PhosphorylationANEIEAISSPLMGIF
HHHHHHHHCCCHHHH		32.7122369663
137PhosphorylationNEIEAISSPLMGIFE
HHHHHHHCCCHHHHH		18.8822369663
227PhosphorylationYCQSVARYGKSPYLY
HHHHHHHHCCCCCEE		21.1122369663
229AcetylationQSVARYGKSPYLYPM
HHHHHHCCCCCEECC		39.0524489116
230PhosphorylationSVARYGKSPYLYPMY
HHHHHCCCCCEECCC		17.8922369663
232PhosphorylationARYGKSPYLYPMYGL
HHHCCCCCEECCCCC		26.4222369663
234PhosphorylationYGKSPYLYPMYGLGE
HCCCCCEECCCCCCC		4.7021440633
274AcetylationLYKKDTGKFEGVKTK
EEECCCCCCCCCCCC		42.1924489116
286AcetylationKTKLGTFKAPLVIAD
CCCCEECCCCEEECC		49.2724489116
406UbiquitinationEPREDGSKDNIYLSR
CCCCCCCCCCEEEEC		61.3923749301
414PhosphorylationDNIYLSRSYDASSHF
CCEEEECCCCHHHCH		24.8022369663
419PhosphorylationSRSYDASSHFESMTD
ECCCCHHHCHHHCCC		33.6419779198
429UbiquitinationESMTDDVKDIYFRVT
HHCCCCCHHHHHHHH		45.4623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GDI1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GDI1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GDI1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YPT1_YEASTYPT1physical
11805826
YPT31_YEASTYPT31physical
11805826
YPT52_YEASTYPT52physical
11805826
YPT31_YEASTYPT31physical
11805837
YPT1_YEASTYPT1physical
11805837
YPT32_YEASTYPT32physical
11805837
VPS21_YEASTVPS21physical
11805837
YPT7_YEASTYPT7physical
11805837
SEC4_YEASTSEC4physical
11805837
YPT10_YEASTYPT10physical
11805837
YPT52_YEASTYPT52physical
11805837
YPT6_YEASTYPT6physical
11805837
STE11_YEASTSTE11physical
11805837
VPS21_YEASTVPS21physical
11116150
YPT7_YEASTYPT7physical
11116150
YPT1_YEASTYPT1physical
11116150
SEC4_YEASTSEC4physical
11116150
YPT1_YEASTYPT1physical
10329679
YPT7_YEASTYPT7physical
10329679
VPS21_YEASTVPS21physical
10329679
SEC4_YEASTSEC4physical
9218467
YPT1_YEASTYPT1physical
16429126
YPT31_YEASTYPT31physical
16429126
YPT52_YEASTYPT52physical
16429126
ATC1_YEASTPMR1genetic
1379856
YPT1_YEASTYPT1physical
18467557
VPS21_YEASTVPS21physical
18467557
YPT6_YEASTYPT6physical
18467557
YPT32_YEASTYPT32physical
18467557
YPT7_YEASTYPT7physical
18467557
SEC4_YEASTSEC4physical
18467557
YPT1_YEASTYPT1physical
16395334
RAEP_YEASTMRS6genetic
12972569
HSP7F_YEASTSSE1genetic
21572441
MON1_YEASTMON1genetic
23979137
CCZ1_YEASTCCZ1genetic
23979137
CDC1_YEASTCDC1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
CDC24_YEASTCDC24genetic
27708008
EXO84_YEASTEXO84genetic
27708008
TRS20_YEASTTRS20genetic
27708008
USO1_YEASTUSO1genetic
27708008
TRS23_YEASTTRS23genetic
27708008
GPI8_YEASTGPI8genetic
27708008
NCS1_YEASTFRQ1genetic
27708008
GPI17_YEASTGPI17genetic
27708008
SEC4_YEASTSEC4genetic
27708008
YPT1_YEASTYPT1genetic
27708008
ACT_YEASTACT1genetic
27708008
SEC15_YEASTSEC15genetic
27708008
YIP1_YEASTYIP1genetic
27708008
ZPR1_YEASTZPR1genetic
27708008
SYMC_YEASTMES1genetic
27708008
CP51_YEASTERG11genetic
27708008
RHO3_YEASTRHO3genetic
27708008
EXO70_YEASTEXO70genetic
27708008
ERG27_YEASTERG27genetic
27708008
CFT2_YEASTCFT2genetic
27708008
SEC10_YEASTSEC10genetic
27708008
POB3_YEASTPOB3genetic
27708008
BET5_YEASTBET5genetic
27708008
GPI12_YEASTGPI12genetic
27708008
CAP_YEASTSRV2genetic
27708008
TYSY_YEASTCDC21genetic
27708008
SEC63_YEASTSEC63genetic
27708008
MYO2_YEASTMYO2genetic
27708008
RAEP_YEASTMRS6genetic
27708008
MOT1_YEASTMOT1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
SEC8_YEASTSEC8genetic
27708008
PGTB2_YEASTBET2genetic
27708008
RXT2_YEASTRXT2genetic
27708008
ARL1_YEASTARL1genetic
27708008
PER1_YEASTPER1genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
RXT3_YEASTRXT3genetic
27708008
SWF1_YEASTSWF1genetic
27708008
SWA2_YEASTSWA2genetic
27708008
BST1_YEASTBST1genetic
27708008
COG7_YEASTCOG7genetic
27708008
RL24A_YEASTRPL24Agenetic
27708008
TFS2_YEASTDST1genetic
27708008
ERV14_YEASTERV14genetic
27708008
DBP3_YEASTDBP3genetic
27708008
GUP1_YEASTGUP1genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
SSF1_YEASTSSF1genetic
27708008
UBA4_YEASTUBA4genetic
27708008
AGE2_YEASTAGE2genetic
27708008
SDS3_YEASTSDS3genetic
27708008
SYS1_YEASTSYS1genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
BFA1_YEASTBFA1genetic
27708008
CBF1_YEASTCBF1genetic
27708008
DHOM_YEASTHOM6genetic
27708008
KTI12_YEASTKTI12genetic
27708008
IRS4_YEASTIRS4genetic
27708008
VPS51_YEASTVPS51genetic
27708008
AIM29_YEASTAIM29genetic
27708008
SRP40_YEASTSRP40genetic
27708008
POM33_YEASTPOM33genetic
27708008
ERG3_YEASTERG3genetic
27708008
ELP1_YEASTIKI3genetic
27708008
ERG6_YEASTERG6genetic
27708008
COG8_YEASTCOG8genetic
27708008
RS10B_YEASTRPS10Bgenetic
27708008
COX7_YEASTCOX7genetic
27708008
SAP30_YEASTSAP30genetic
27708008
TMA23_YEASTTMA23genetic
27708008
COG6_YEASTCOG6genetic
27708008
PHO23_YEASTPHO23genetic
27708008
CTU2_YEASTNCS2genetic
27708008
MSO1_YEASTMSO1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
TLG2_YEASTTLG2genetic
27708008
DCAM_YEASTSPE2genetic
27708008
VPS21_YEASTVPS21genetic
27708008
SERC_YEASTSER1genetic
27708008
RUD3_YEASTRUD3genetic
27708008
SNC2_YEASTSNC2genetic
27708008
ARL3_YEASTARL3genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
ELP3_YEASTELP3genetic
27708008
ELP4_YEASTELP4genetic
27708008
NEW1_YEASTNEW1genetic
27708008
SRO7_YEASTSRO7genetic
27708008
SPEE_YEASTSPE3genetic
27708008
OPY2_YEASTOPY2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GDI1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, AND MASSSPECTROMETRY.

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